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@ARTICLE{Benito:139900,
      author       = {Benito, Eva and Kerimoglu, Cemil and Ramachandran, Binu and
                      Pena Centeno, Tonatiuh and Jain, Gaurav and Stilling, Roman
                      Manuel and Islam, Rezaul and Capece, Vincenzo and Zhou,
                      Qihui and Edbauer, Dieter and Dean, Camin and Fischer,
                      André},
      title        = {{RNA}-{D}ependent {I}ntergenerational {I}nheritance of
                      {E}nhanced {S}ynaptic {P}lasticity after {E}nvironmental
                      {E}nrichment.},
      journal      = {Cell reports},
      volume       = {23},
      number       = {2},
      issn         = {2211-1247},
      address      = {[New York, NY]},
      publisher    = {Elsevier},
      reportid     = {DZNE-2020-06222},
      pages        = {546-554},
      year         = {2018},
      abstract     = {Physical exercise in combination with cognitive training is
                      known to enhance synaptic plasticity, learning, and memory
                      and lower the risk for various complex diseases including
                      Alzheimer's disease. Here, we show that exposure of adult
                      male mice to an environmental enrichment paradigm leads to
                      enhancement of synaptic plasticity and cognition also in the
                      next generation. We show that this effect is mediated
                      through sperm RNA and especially miRs 212/132. In
                      conclusion, our study reports intergenerational inheritance
                      of an acquired cognitive benefit and points to specific miRs
                      as candidates mechanistically involved in this type of
                      transmission.},
      keywords     = {Animals / Behavior, Animal / Brain: metabolism / Cognition:
                      physiology / Excitatory Postsynaptic Potentials /
                      Hippocampus: physiology / Male / Mice / Mice, Inbred C57BL /
                      MicroRNAs: chemistry / MicroRNAs: metabolism / Neuronal
                      Plasticity: physiology / Physical Conditioning, Animal /
                      RNA: chemistry / RNA: isolation $\&$ purification / RNA:
                      metabolism / Sequence Analysis, RNA / Social Environment /
                      Spermatozoa: metabolism / MIRN132 microRNA, rat (NLM
                      Chemicals) / MIRN212 microRNA, rat (NLM Chemicals) /
                      MicroRNAs (NLM Chemicals) / RNA (NLM Chemicals)},
      cin          = {AG Fischer / AG Edbauer / Bioinformatics and Genome
                      Dynamics Core / Göttingen common / AG Bonn 2 / AG Zhou},
      ddc          = {610},
      cid          = {I:(DE-2719)1410002 / I:(DE-2719)1110004 /
                      I:(DE-2719)1440016 / I:(DE-2719)6000014 / I:(DE-2719)1440012
                      / I:(DE-2719)5000080},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29642011},
      pmc          = {pmc:PMC5912949},
      doi          = {10.1016/j.celrep.2018.03.059},
      url          = {https://pub.dzne.de/record/139900},
}