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000139909 1001_ $$0P:(DE-2719)2814015$$aWendeln, Ann-Christin$$b0$$eFirst author
000139909 245__ $$aInnate immune memory in the brain shapes neurological disease hallmarks.
000139909 260__ $$aLondon [u.a.]$$bNature Publ. Group65848$$c2018
000139909 264_1 $$2Crossref$$3online$$bSpringer Science and Business Media LLC$$c2018-04-11
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000139909 520__ $$aInnate immune memory is a vital mechanism of myeloid cell plasticity that occurs in response to environmental stimuli and alters subsequent immune responses. Two types of immunological imprinting can be distinguished-training and tolerance. These are epigenetically mediated and enhance or suppress subsequent inflammation, respectively. Whether immune memory occurs in tissue-resident macrophages in vivo and how it may affect pathology remains largely unknown. Here we demonstrate that peripherally applied inflammatory stimuli induce acute immune training and tolerance in the brain and lead to differential epigenetic reprogramming of brain-resident macrophages (microglia) that persists for at least six months. Strikingly, in a mouse model of Alzheimer's pathology, immune training exacerbates cerebral β-amyloidosis and immune tolerance alleviates it; similarly, peripheral immune stimulation modifies pathological features after stroke. Our results identify immune memory in the brain as an important modifier of neuropathology.
000139909 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
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000139909 542__ $$2Crossref$$i2018-04-01$$uhttp://www.springer.com/tdm
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000139909 650_2 $$2MeSH$$aAlzheimer Disease: immunology
000139909 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000139909 650_2 $$2MeSH$$aAmyloidosis: immunology
000139909 650_2 $$2MeSH$$aAmyloidosis: pathology
000139909 650_2 $$2MeSH$$aAnimals
000139909 650_2 $$2MeSH$$aBrain: immunology
000139909 650_2 $$2MeSH$$aBrain: pathology
000139909 650_2 $$2MeSH$$aDisease Models, Animal
000139909 650_2 $$2MeSH$$aEpigenesis, Genetic
000139909 650_2 $$2MeSH$$aFemale
000139909 650_2 $$2MeSH$$aGene Expression Regulation: immunology
000139909 650_2 $$2MeSH$$aHumans
000139909 650_2 $$2MeSH$$aImmune Tolerance
000139909 650_2 $$2MeSH$$aImmunity, Innate
000139909 650_2 $$2MeSH$$aImmunologic Memory
000139909 650_2 $$2MeSH$$aInflammation: genetics
000139909 650_2 $$2MeSH$$aInflammation: immunology
000139909 650_2 $$2MeSH$$aMale
000139909 650_2 $$2MeSH$$aMice
000139909 650_2 $$2MeSH$$aMicroglia: immunology
000139909 650_2 $$2MeSH$$aMicroglia: metabolism
000139909 650_2 $$2MeSH$$aNervous System Diseases: immunology
000139909 650_2 $$2MeSH$$aNervous System Diseases: pathology
000139909 650_2 $$2MeSH$$aStroke: immunology
000139909 650_2 $$2MeSH$$aStroke: pathology
000139909 7001_ $$0P:(DE-2719)2810939$$aDegenhardt, Karoline$$b1
000139909 7001_ $$0P:(DE-2719)2812832$$aKaurani, Lalit$$b2
000139909 7001_ $$0P:(DE-2719)2810722$$aGertig, Michael$$b3
000139909 7001_ $$0P:(DE-HGF)0$$aUlas, Thomas$$b4
000139909 7001_ $$0P:(DE-2719)2811223$$aJain, Gaurav$$b5
000139909 7001_ $$0P:(DE-2719)2812193$$aWagner, Jessica$$b6
000139909 7001_ $$0P:(DE-2719)2811581$$aHäsler, Lisa M$$b7
000139909 7001_ $$0P:(DE-2719)2811762$$aWild, Katleen$$b8
000139909 7001_ $$0P:(DE-2719)2810430$$aSkodras, Angelos$$b9
000139909 7001_ $$0P:(DE-HGF)0$$aBlank, Thomas$$b10
000139909 7001_ $$0P:(DE-HGF)0$$aStaszewski, Ori$$b11
000139909 7001_ $$0P:(DE-HGF)0$$aDatta, Moumita$$b12
000139909 7001_ $$0P:(DE-2719)2811063$$aPena Centeno, Tonatiuh$$b13$$udzne
000139909 7001_ $$0P:(DE-2719)2810626$$aCapece, Vincenzo$$b14
000139909 7001_ $$0P:(DE-2719)2811643$$aIslam, Rezaul$$b15
000139909 7001_ $$0P:(DE-2719)2812366$$aKerimoglu, Cemil$$b16
000139909 7001_ $$0P:(DE-2719)9000301$$aStaufenbiel, Matthias$$b17
000139909 7001_ $$0P:(DE-2719)2811660$$aSchultze, Joachim L$$b18
000139909 7001_ $$0P:(DE-2719)2812219$$aBeyer, Marc$$b19
000139909 7001_ $$0P:(DE-HGF)0$$aPrinz, Marco$$b20
000139909 7001_ $$0P:(DE-2719)2000010$$aJucker, Mathias$$b21
000139909 7001_ $$0P:(DE-2719)2000047$$aFischer, André$$b22
000139909 7001_ $$0P:(DE-2719)2811021$$aNeher, Jonas J$$b23$$eLast author
000139909 77318 $$2Crossref$$3journal-article$$a10.1038/s41586-018-0023-4$$b : Springer Science and Business Media LLC, 2018-04-01$$n7701$$p332-338$$tNature$$v556$$x0028-0836$$y2018
000139909 773__ $$0PERI:(DE-600)1413423-8$$a10.1038/s41586-018-0023-4$$gVol. 556, no. 7701, p. 332 - 338$$n7701$$p332-338$$q556:7701<332 - 338$$tNature <London>$$v556$$x0028-0836$$y2018
000139909 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038912
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