Home > Publications Database > Innate immune memory in the brain shapes neurological disease hallmarks. > print

001     139909
005     20240321220716.0
024 7 _ |a 10.1038/s41586-018-0023-4
|2 doi
024 7 _ |a pmid:29643512
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024 7 _ |a pmc:PMC6038912
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024 7 _ |a 0028-0836
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024 7 _ |a 1476-4687
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037 _ _ |a DZNE-2020-06231
041 _ _ |a English
082 _ _ |a 500
100 1 _ |a Wendeln, Ann-Christin
|0 P:(DE-2719)2814015
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|e First author
245 _ _ |a Innate immune memory in the brain shapes neurological disease hallmarks.
260 _ _ |a London [u.a.]
|c 2018
|b Nature Publ. Group65848
264 _ 1 |3 online
|2 Crossref
|b Springer Science and Business Media LLC
|c 2018-04-11
264 _ 1 |3 print
|2 Crossref
|b Springer Science and Business Media LLC
|c 2018-04-01
336 7 _ |a article
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336 7 _ |a Output Types/Journal article
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336 7 _ |a Journal Article
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336 7 _ |a ARTICLE
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336 7 _ |a JOURNAL_ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a Innate immune memory is a vital mechanism of myeloid cell plasticity that occurs in response to environmental stimuli and alters subsequent immune responses. Two types of immunological imprinting can be distinguished-training and tolerance. These are epigenetically mediated and enhance or suppress subsequent inflammation, respectively. Whether immune memory occurs in tissue-resident macrophages in vivo and how it may affect pathology remains largely unknown. Here we demonstrate that peripherally applied inflammatory stimuli induce acute immune training and tolerance in the brain and lead to differential epigenetic reprogramming of brain-resident macrophages (microglia) that persists for at least six months. Strikingly, in a mouse model of Alzheimer's pathology, immune training exacerbates cerebral β-amyloidosis and immune tolerance alleviates it; similarly, peripheral immune stimulation modifies pathological features after stroke. Our results identify immune memory in the brain as an important modifier of neuropathology.
536 _ _ |a 342 - Disease Mechanisms and Model Systems (POF3-342)
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542 _ _ |i 2018-04-01
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588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 2 |a Alzheimer Disease: immunology
|2 MeSH
650 _ 2 |a Alzheimer Disease: pathology
|2 MeSH
650 _ 2 |a Amyloidosis: immunology
|2 MeSH
650 _ 2 |a Amyloidosis: pathology
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Brain: immunology
|2 MeSH
650 _ 2 |a Brain: pathology
|2 MeSH
650 _ 2 |a Disease Models, Animal
|2 MeSH
650 _ 2 |a Epigenesis, Genetic
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Gene Expression Regulation: immunology
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Immune Tolerance
|2 MeSH
650 _ 2 |a Immunity, Innate
|2 MeSH
650 _ 2 |a Immunologic Memory
|2 MeSH
650 _ 2 |a Inflammation: genetics
|2 MeSH
650 _ 2 |a Inflammation: immunology
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Microglia: immunology
|2 MeSH
650 _ 2 |a Microglia: metabolism
|2 MeSH
650 _ 2 |a Nervous System Diseases: immunology
|2 MeSH
650 _ 2 |a Nervous System Diseases: pathology
|2 MeSH
650 _ 2 |a Stroke: immunology
|2 MeSH
650 _ 2 |a Stroke: pathology
|2 MeSH
700 1 _ |a Degenhardt, Karoline
|0 P:(DE-2719)2810939
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700 1 _ |a Kaurani, Lalit
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700 1 _ |a Gertig, Michael
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700 1 _ |a Ulas, Thomas
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700 1 _ |a Jain, Gaurav
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700 1 _ |a Wagner, Jessica
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700 1 _ |a Häsler, Lisa M
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700 1 _ |a Wild, Katleen
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700 1 _ |a Skodras, Angelos
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700 1 _ |a Blank, Thomas
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700 1 _ |a Staszewski, Ori
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700 1 _ |a Datta, Moumita
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700 1 _ |a Pena Centeno, Tonatiuh
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700 1 _ |a Capece, Vincenzo
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700 1 _ |a Islam, Rezaul
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700 1 _ |a Kerimoglu, Cemil
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700 1 _ |a Staufenbiel, Matthias
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700 1 _ |a Schultze, Joachim L
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700 1 _ |a Beyer, Marc
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700 1 _ |a Prinz, Marco
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700 1 _ |a Jucker, Mathias
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700 1 _ |a Fischer, André
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700 1 _ |a Neher, Jonas J
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773 1 8 |a 10.1038/s41586-018-0023-4
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|v 556
|y 2018
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773 _ _ |a 10.1038/s41586-018-0023-4
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LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21