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@ARTICLE{Galazky:139970,
      author       = {Galazky, Imke and Kaufmann, Jörn and Lorenzl, Stefan and
                      Ebersbach, Georg and Gandor, Florin and Zaehle, Tino and
                      Specht, Sylke and Stallforth, Sabine and Sobieray, Uwe and
                      Wirkus, Edyta and Casjens, Franziska and Heinze, Hans-Jochen
                      and Kupsch, Andreas and Voges, Jürgen},
      title        = {{D}eep brain stimulation of the pedunculopontine nucleus
                      for treatment of gait and balance disorder in progressive
                      supranuclear palsy: {E}ffects of frequency modulations and
                      clinical outcome.},
      journal      = {Parkinsonism $\&$ related disorders},
      volume       = {50},
      issn         = {1353-8020},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2020-06292},
      pages        = {81-86},
      year         = {2018},
      abstract     = {The pedunculopontine nucleus has been suggested as a
                      potential deep brain stimulation target for axial symptoms
                      such as gait and balance impairment in idiopathic
                      Parkinson's disease as well as atypical Parkinsonian
                      disorders.Seven consecutive patients with progressive
                      supranuclear palsy received bilateral pedunculopontine
                      nucleus deep brain stimulation. Inclusion criteria comprised
                      of the clinical diagnosis of progressive supranuclear palsy,
                      a levodopa-resistant gait and balance disorder, age <75
                      years, and absence of dementia or major psychiatric
                      co-morbidities. Effects of stimulation frequencies at 8, 20,
                      60 and 130 Hz on motor scores and gait were assessed. Motor
                      scores were followed up for two years postoperatively.
                      Activities of daily living, frequency of falls,
                      health-related quality of life, cognition and mood at 12
                      months were compared to baseline parameters. Surgical and
                      stimulation related adverse events were assessed.Bilateral
                      pedunculopontine nucleus deep brain stimulation at 8 Hz
                      significantly improved axial motor symptoms and cyclic gait
                      parameters, while high frequency stimulation did not
                      ameliorate gait and balance but improved hypokinesia. This
                      improvement however did not translate into clinically
                      relevant benefits. Frequency of falls was not reduced.
                      Activities of daily living, quality of life and frontal
                      cognitive functions declined, while mood remained
                      unchanged.Bilateral pedunculopontine nucleus deep brain
                      stimulation in progressive supranuclear palsy generates
                      frequency-dependent effects with improvement of cyclic gait
                      parameters at low frequency and amelioration of hypokinesia
                      at high frequency stimulation. However, these effects do not
                      translate into a clinically important improvement.},
      keywords     = {Accidental Falls: prevention $\&$ control / Activities of
                      Daily Living / Aged / Cognitive Dysfunction: etiology /
                      Cognitive Dysfunction: therapy / Deep Brain Stimulation:
                      methods / Female / Gait Disorders, Neurologic: etiology /
                      Gait Disorders, Neurologic: therapy / Humans / Hypokinesia:
                      etiology / Hypokinesia: therapy / Male / Outcome Assessment,
                      Health Care / Pedunculopontine Tegmental Nucleus / Postural
                      Balance / Quality of Life / Supranuclear Palsy, Progressive:
                      complications / Supranuclear Palsy, Progressive: therapy /
                      Deep brain stimulation (Other) / Gait (Other) / Parkinsonian
                      disorders (Other) / Pedunculopontine nucleus (Other) /
                      Progressive supranuclear palsy (Other) / Quality of life
                      (Other)},
      cin          = {Core Technical Staff / U Clinical Researchers - Magdeburg},
      ddc          = {610},
      cid          = {I:(DE-2719)1340007 / I:(DE-2719)7000000},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29503154},
      doi          = {10.1016/j.parkreldis.2018.02.027},
      url          = {https://pub.dzne.de/record/139970},
}