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000139996 1001_ $$avan der Lee, Sven J$$b0
000139996 245__ $$aCirculating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies.
000139996 260__ $$aAmsterdam [u.a.]$$bElsevier$$c2018
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000139996 520__ $$aIdentifying circulating metabolites that are associated with cognition and dementia may improve our understanding of the pathogenesis of dementia and provide crucial readouts for preventive and therapeutic interventions.We studied 299 metabolites in relation to cognition (general cognitive ability) in two discovery cohorts (N total = 5658). Metabolites significantly associated with cognition after adjusting for multiple testing were replicated in four independent cohorts (N total = 6652), and the associations with dementia and Alzheimer's disease (N = 25,872) and lifestyle factors (N = 5168) were examined.We discovered and replicated 15 metabolites associated with cognition including subfractions of high-density lipoprotein, docosahexaenoic acid, ornithine, glutamine, and glycoprotein acetyls. These associations were independent of classical risk factors including high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, glucose, and apolipoprotein E (APOE) genotypes. Six of the cognition-associated metabolites were related to the risk of dementia and lifestyle factors.Circulating metabolites were consistently associated with cognition, dementia, and lifestyle factors, opening new avenues for prevention of cognitive decline and dementia.
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000139996 650_7 $$2NLM Chemicals$$aBiomarkers
000139996 650_2 $$2MeSH$$aAdult
000139996 650_2 $$2MeSH$$aAged
000139996 650_2 $$2MeSH$$aAlzheimer Disease: metabolism
000139996 650_2 $$2MeSH$$aBiomarkers: metabolism
000139996 650_2 $$2MeSH$$aCognitive Dysfunction: metabolism
000139996 650_2 $$2MeSH$$aCohort Studies
000139996 650_2 $$2MeSH$$aDementia: metabolism
000139996 650_2 $$2MeSH$$aFemale
000139996 650_2 $$2MeSH$$aHumans
000139996 650_2 $$2MeSH$$aLife Style
000139996 650_2 $$2MeSH$$aMale
000139996 650_2 $$2MeSH$$aMiddle Aged
000139996 650_2 $$2MeSH$$aReproducibility of Results
000139996 650_2 $$2MeSH$$aRisk Factors
000139996 7001_ $$aTeunissen, Charlotte E$$b1
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000139996 77318 $$2Crossref$$3journal-article$$a10.1016/j.jalz.2017.11.012$$b : Wiley, 2018-01-06$$n6$$p707-722$$tAlzheimer's & Dementia$$v14$$x1552-5260$$y2018
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000139996 7870_ $$0DZNE-2020-00510$$aMelo van Lent, Debora et.al.$$dAmsterdam [u.a.] : Elsevier, 2019$$iRelatedTo$$r$$tErratum to 'Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies' [Alzheimer's & Dementia 2018;14:707-22.].
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