TY  - JOUR
AU  - van der Lee, Sven J
AU  - Teunissen, Charlotte E
AU  - Pool, René
AU  - Shipley, Martin J
AU  - Teumer, Alexander
AU  - Chouraki, Vincent
AU  - Melo van Lent, Debora
AU  - Tynkkynen, Juho
AU  - Fischer, Krista
AU  - Hernesniemi, Jussi
AU  - Haller, Toomas
AU  - Singh-Manoux, Archana
AU  - Verhoeven, Aswin
AU  - Willemsen, Gonneke
AU  - de Leeuw, Francisca A
AU  - Wagner, Holger
AU  - van Dongen, Jenny
AU  - Hertel, Johannes
AU  - Budde, Kathrin
AU  - Willems van Dijk, Ko
AU  - Weinhold, Leonie
AU  - Ikram, M Arfan
AU  - Pietzner, Maik
AU  - Perola, Markus
AU  - Wagner, Michael
AU  - Friedrich, Nele
AU  - Slagboom, P Eline
AU  - Scheltens, Philip
AU  - Yang, Qiong
AU  - Gertzen, Robert E
AU  - Egert, Sarah
AU  - Li, Shuo
AU  - Hankemeier, Thomas
AU  - van Beijsterveldt, Catharina E M
AU  - Vasan, Ramachandran S
AU  - Maier, Wolfgang
AU  - Peeters, Carel F W
AU  - Grabe, Hans
AU  - Ramirez, Alfredo
AU  - Seshadri, Sudha
AU  - Metspalu, Andres
AU  - Kivimäki, Mika
AU  - Salomaa, Veikko
AU  - Demirkan, Ayşe
AU  - Boomsma, Dorret I
AU  - van der Flier, Wiesje M
AU  - Amin, Najaf
AU  - van Duijn, Cornelia M
TI  - Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies.
JO  - Alzheimer's and dementia
VL  - 14
IS  - 6
SN  - 1552-5260
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DZNE-2020-06318
SP  - 707-722
PY  - 2018
AB  - Identifying circulating metabolites that are associated with cognition and dementia may improve our understanding of the pathogenesis of dementia and provide crucial readouts for preventive and therapeutic interventions.We studied 299 metabolites in relation to cognition (general cognitive ability) in two discovery cohorts (N total = 5658). Metabolites significantly associated with cognition after adjusting for multiple testing were replicated in four independent cohorts (N total = 6652), and the associations with dementia and Alzheimer's disease (N = 25,872) and lifestyle factors (N = 5168) were examined.We discovered and replicated 15 metabolites associated with cognition including subfractions of high-density lipoprotein, docosahexaenoic acid, ornithine, glutamine, and glycoprotein acetyls. These associations were independent of classical risk factors including high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, glucose, and apolipoprotein E (APOE) genotypes. Six of the cognition-associated metabolites were related to the risk of dementia and lifestyle factors.Circulating metabolites were consistently associated with cognition, dementia, and lifestyle factors, opening new avenues for prevention of cognitive decline and dementia.
KW  - Adult
KW  - Aged
KW  - Alzheimer Disease: metabolism
KW  - Biomarkers: metabolism
KW  - Cognitive Dysfunction: metabolism
KW  - Cohort Studies
KW  - Dementia: metabolism
KW  - Female
KW  - Humans
KW  - Life Style
KW  - Male
KW  - Middle Aged
KW  - Reproducibility of Results
KW  - Risk Factors
KW  - Biomarkers (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:29316447
DO  - DOI:10.1016/j.jalz.2017.11.012
UR  - https://pub.dzne.de/record/139996
ER  -