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@ARTICLE{vanderLee:139996,
      author       = {van der Lee, Sven J and Teunissen, Charlotte E and Pool,
                      René and Shipley, Martin J and Teumer, Alexander and
                      Chouraki, Vincent and Melo van Lent, Debora and Tynkkynen,
                      Juho and Fischer, Krista and Hernesniemi, Jussi and Haller,
                      Toomas and Singh-Manoux, Archana and Verhoeven, Aswin and
                      Willemsen, Gonneke and de Leeuw, Francisca A and Wagner,
                      Holger and van Dongen, Jenny and Hertel, Johannes and Budde,
                      Kathrin and Willems van Dijk, Ko and Weinhold, Leonie and
                      Ikram, M Arfan and Pietzner, Maik and Perola, Markus and
                      Wagner, Michael and Friedrich, Nele and Slagboom, P Eline
                      and Scheltens, Philip and Yang, Qiong and Gertzen, Robert E
                      and Egert, Sarah and Li, Shuo and Hankemeier, Thomas and van
                      Beijsterveldt, Catharina E M and Vasan, Ramachandran S and
                      Maier, Wolfgang and Peeters, Carel F W and Grabe, Hans and
                      Ramirez, Alfredo and Seshadri, Sudha and Metspalu, Andres
                      and Kivimäki, Mika and Salomaa, Veikko and Demirkan, Ayşe
                      and Boomsma, Dorret I and van der Flier, Wiesje M and Amin,
                      Najaf and van Duijn, Cornelia M},
      title        = {{C}irculating metabolites and general cognitive ability and
                      dementia: {E}vidence from 11 cohort studies.},
      journal      = {Alzheimer's and dementia},
      volume       = {14},
      number       = {6},
      issn         = {1552-5260},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DZNE-2020-06318},
      pages        = {707-722},
      year         = {2018},
      abstract     = {Identifying circulating metabolites that are associated
                      with cognition and dementia may improve our understanding of
                      the pathogenesis of dementia and provide crucial readouts
                      for preventive and therapeutic interventions.We studied 299
                      metabolites in relation to cognition (general cognitive
                      ability) in two discovery cohorts (N total = 5658).
                      Metabolites significantly associated with cognition after
                      adjusting for multiple testing were replicated in four
                      independent cohorts (N total = 6652), and the associations
                      with dementia and Alzheimer's disease (N = 25,872) and
                      lifestyle factors (N = 5168) were examined.We discovered
                      and replicated 15 metabolites associated with cognition
                      including subfractions of high-density lipoprotein,
                      docosahexaenoic acid, ornithine, glutamine, and glycoprotein
                      acetyls. These associations were independent of classical
                      risk factors including high-density lipoprotein cholesterol,
                      low-density lipoprotein cholesterol, triglycerides, glucose,
                      and apolipoprotein E (APOE) genotypes. Six of the
                      cognition-associated metabolites were related to the risk of
                      dementia and lifestyle factors.Circulating metabolites were
                      consistently associated with cognition, dementia, and
                      lifestyle factors, opening new avenues for prevention of
                      cognitive decline and dementia.},
      keywords     = {Adult / Aged / Alzheimer Disease: metabolism / Biomarkers:
                      metabolism / Cognitive Dysfunction: metabolism / Cohort
                      Studies / Dementia: metabolism / Female / Humans / Life
                      Style / Male / Middle Aged / Reproducibility of Results /
                      Risk Factors / Biomarkers (NLM Chemicals)},
      cin          = {AG Wagner / U Clinical Researchers - Bonn / AG Grabe},
      ddc          = {610},
      cid          = {I:(DE-2719)1011201 / I:(DE-2719)7000001 /
                      I:(DE-2719)5000001},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29316447},
      doi          = {10.1016/j.jalz.2017.11.012},
      url          = {https://pub.dzne.de/record/139996},
}