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@ARTICLE{Tamgney:140025,
      author       = {Tamgüney, Gültekin and Korczyn, Amos D},
      title        = {{A} critical review of the prion hypothesis of human
                      synucleinopathies.},
      journal      = {Cell $\&$ tissue research},
      volume       = {373},
      number       = {1},
      issn         = {0302-766X},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DZNE-2020-06347},
      pages        = {213-220},
      year         = {2018},
      abstract     = {Parkinson's disease (PD), dementia with Lewy bodies (DLB),
                      and multiple system atrophy (MSA) are neurodegenerative
                      disorders which have been pathologically classified as
                      synucleinopathies, since they are associated with
                      pathognomonic deposits of misfolded alpha-synuclein in cells
                      of the nervous system. Recently PD, DLB, and MSA were also
                      suggested to be prion-like disorders. Much controversy
                      exists regarding this analogy between synucleinopathies and
                      prion diseases. Here, we discuss what characterizes prion
                      diseases and in which way synucleinopathies may be
                      considered prion-like or -unlike. We critically review
                      recent clinical and in vivo evidence from transmission
                      studies to animals in support of or questioning the prion
                      hypothesis of human synucleinopathies. We conclude that,
                      although PD, DLB, and MSA fulfill many criteria of
                      prion-likeness, they also still fail some of these
                      criteria.},
      subtyp        = {Review Article},
      keywords     = {Humans / Models, Biological / Neurodegenerative Diseases:
                      metabolism / Neurodegenerative Diseases: pathology / Prions:
                      metabolism / alpha-Synuclein: metabolism / Prions (NLM
                      Chemicals) / alpha-Synuclein (NLM Chemicals)},
      cin          = {AG Tamgüney 2},
      ddc          = {610},
      cid          = {I:(DE-2719)1013022},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29116402},
      doi          = {10.1007/s00441-017-2712-y},
      url          = {https://pub.dzne.de/record/140025},
}