Home > Publications Database > A critical review of the prion hypothesis of human synucleinopathies. > print

001     140025
005     20240403104933.0
024 7 _ |a 2192-5917
|2 ISSN
024 7 _ |a 10.1007/s00441-017-2712-y
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024 7 _ |a pmid:29116402
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037 _ _ |a DZNE-2020-06347
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Tamgüney, Gültekin
|0 P:(DE-2719)2810376
|b 0
|e First author
|u dzne
245 _ _ |a A critical review of the prion hypothesis of human synucleinopathies.
260 _ _ |a Heidelberg
|c 2018
|b Springer
264 _ 1 |3 online
|2 Crossref
|b Springer Science and Business Media LLC
|c 2017-11-08
264 _ 1 |3 print
|2 Crossref
|b Springer Science and Business Media LLC
|c 2018-07-01
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
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336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1712134096_27004
|2 PUB:(DE-HGF)
|x Review Article
336 7 _ |a ARTICLE
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336 7 _ |a JOURNAL_ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA) are neurodegenerative disorders which have been pathologically classified as synucleinopathies, since they are associated with pathognomonic deposits of misfolded alpha-synuclein in cells of the nervous system. Recently PD, DLB, and MSA were also suggested to be prion-like disorders. Much controversy exists regarding this analogy between synucleinopathies and prion diseases. Here, we discuss what characterizes prion diseases and in which way synucleinopathies may be considered prion-like or -unlike. We critically review recent clinical and in vivo evidence from transmission studies to animals in support of or questioning the prion hypothesis of human synucleinopathies. We conclude that, although PD, DLB, and MSA fulfill many criteria of prion-likeness, they also still fail some of these criteria.
536 _ _ |a 342 - Disease Mechanisms and Model Systems (POF3-342)
|0 G:(DE-HGF)POF3-342
|c POF3-342
|f POF III
|x 0
542 _ _ |i 2017-11-08
|2 Crossref
|u http://www.springer.com/tdm
588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 7 |a Prions
|2 NLM Chemicals
650 _ 7 |a alpha-Synuclein
|2 NLM Chemicals
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Models, Biological
|2 MeSH
650 _ 2 |a Neurodegenerative Diseases: metabolism
|2 MeSH
650 _ 2 |a Neurodegenerative Diseases: pathology
|2 MeSH
650 _ 2 |a Prions: metabolism
|2 MeSH
650 _ 2 |a alpha-Synuclein: metabolism
|2 MeSH
700 1 _ |a Korczyn, Amos D
|0 P:(DE-HGF)0
|b 1
773 1 8 |a 10.1007/s00441-017-2712-y
|b : Springer Science and Business Media LLC, 2017-11-08
|n 1
|p 213-220
|3 journal-article
|2 Crossref
|t Cell and Tissue Research
|v 373
|y 2017
|x 0302-766X
773 _ _ |a 10.1007/s00441-017-2712-y
|g Vol. 373, no. 1, p. 213 - 220
|0 PERI:(DE-600)1458496-7
|n 1
|q 373:1<213 - 220
|p 213-220
|t Cell & tissue research
|v 373
|y 2018
|x 0302-766X
856 4 _ |u https://pub.dzne.de/record/140025/files/DZNE-2020-06347_Restricted.pdf
856 4 _ |u https://pub.dzne.de/record/140025/files/DZNE-2020-06347_Restricted.pdf?subformat=pdfa
|x pdfa
909 C O |p VDB
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 0
|6 P:(DE-2719)2810376
913 1 _ |a DE-HGF
|b Gesundheit
|l Erkrankungen des Nervensystems
|1 G:(DE-HGF)POF3-340
|0 G:(DE-HGF)POF3-342
|3 G:(DE-HGF)POF3
|2 G:(DE-HGF)POF3-300
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|v Disease Mechanisms and Model Systems
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914 1 _ |y 2018
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920 1 _ |0 I:(DE-2719)1013022
|k AG Tamgüney 2
|l Prion and prion-like diseases
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