% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Ruschel:140031,
      author       = {Ruschel, Jörg and Bradke, Frank},
      title        = {{S}ystemic administration of epothilone {D} improves
                      functional recovery of walking after rat spinal cord
                      contusion injury.},
      journal      = {Experimental neurology},
      volume       = {306},
      issn         = {0014-4886},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {DZNE-2020-06353},
      pages        = {243-249},
      year         = {2018},
      abstract     = {Central nervous system (CNS) injuries cause permanent
                      impairments of sensorimotor functions as mature neurons fail
                      to regenerate their severed axons. The poor intrinsic growth
                      capacity of adult CNS neurons and the formation of an
                      inhibitory lesion scar are key impediments to axon
                      regeneration. Systemic administration of the microtubule
                      stabilizing agent epothilone B promotes axon regeneration
                      and recovery of motor function by activating the intrinsic
                      axonal growth machinery and by reducing the inhibitory
                      fibrotic lesion scar. Thus, epothilones hold clinical
                      promise as potential therapeutics for spinal cord injury.
                      Here we tested the efficacy of epothilone D, an epothilone B
                      analog with a superior safety profile. By using liquid
                      chromatography and mass spectrometry (LC/MS), we found
                      adequate CNS penetration and distribution of epothilone D
                      after systemic administration, confirming the suitability of
                      the drug for non-invasive CNS treatment. Systemic
                      administration of epothilone D reduced inhibitory fibrotic
                      scarring, promoted regrowth of injured raphespinal fibers
                      and improved walking function after mid-thoracic spinal cord
                      contusion injury in adult rats. These results confirm that
                      systemic administration of epothilones is a valuable
                      therapeutic strategy for CNS regeneration and repair after
                      injury and provides a further advance for potential clinical
                      translation.},
      cin          = {AG Bradke},
      ddc          = {610},
      cid          = {I:(DE-2719)1013002},
      pnm          = {341 - Molecular Signaling (POF3-341)},
      pid          = {G:(DE-HGF)POF3-341},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29223322},
      doi          = {10.1016/j.expneurol.2017.12.001},
      url          = {https://pub.dzne.de/record/140031},
}