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000140037 1001_ $$0P:(DE-HGF)0$$aWolf, Dominik$$b0$$eCorresponding author
000140037 245__ $$aMechanisms and modulators of cognitive training gain transfer in cognitively healthy aging: study protocol of the AgeGain study.
000140037 260__ $$aLondon$$bBioMed Central$$c2018
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000140037 520__ $$aCognitively healthy older people can increase their performance in cognitive tasks through training. However, training effects are mostly limited to the trained task; thus, training effects only poorly transfer to untrained tasks or other contexts, which contributes to reduced adaptation abilities in aging. Stabilizing transfer capabilities in aging would increase the chance of persistent high performance in activities of daily living including longer independency, and prolonged active participation in social life. The trial AgeGain aims at elaborating the physiological brain mechanisms of transfer in aging and supposed major modulators of transfer capability, especially physical activity, cerebral vascular lesions, and amyloid burden.This 4-year interventional, multicenter, phase 2a cognitive and physical training study will enroll 237 cognitively healthy older subjects in four recruiting centers. The primary endpoint of this trial is the prediction of transfer of cognitive training gains. Secondary endpoints are the structural connectivity of the corpus callosum, Default Mode Network activity, brain-derived neurotrophic factors, motor fitness, and maximal oxygen uptake.Cognitive transfer allows making use of cognitive training gains in everyday life. Thus, maintenance of transfer capability with aging increases the chance of persistent self-guidance and prolonged active participation in social life, which may support a good quality of life. The AgeGain study aims at identifying older people who will most benefit from cognitive training. It will increase the understanding of the neurobiological mechanisms of transfer in aging and will help in determining the impact of physical activity and sport as well as pathologic factors (such as cerebrovascular disease and amyloid load) on transfer capability.German Clinical Trials Register (DRKS), ID: DRKS00013077 . Registered on 19 November 2017.
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000140037 650_7 $$2NLM Chemicals$$aBrain-Derived Neurotrophic Factor
000140037 650_7 $$07171WSG8A2$$2NLM Chemicals$$aBDNF protein, human
000140037 650_2 $$2MeSH$$aAge Factors
000140037 650_2 $$2MeSH$$aBrain: diagnostic imaging
000140037 650_2 $$2MeSH$$aBrain: metabolism
000140037 650_2 $$2MeSH$$aBrain: physiology
000140037 650_2 $$2MeSH$$aBrain-Derived Neurotrophic Factor: metabolism
000140037 650_2 $$2MeSH$$aClinical Trials, Phase II as Topic
000140037 650_2 $$2MeSH$$aCognition
000140037 650_2 $$2MeSH$$aCognitive Aging: psychology
000140037 650_2 $$2MeSH$$aCognitive Behavioral Therapy: methods
000140037 650_2 $$2MeSH$$aCorpus Callosum: diagnostic imaging
000140037 650_2 $$2MeSH$$aCorpus Callosum: physiology
000140037 650_2 $$2MeSH$$aExercise Test
000140037 650_2 $$2MeSH$$aFemale
000140037 650_2 $$2MeSH$$aGermany
000140037 650_2 $$2MeSH$$aHealthy Aging: psychology
000140037 650_2 $$2MeSH$$aHumans
000140037 650_2 $$2MeSH$$aLongitudinal Studies
000140037 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000140037 650_2 $$2MeSH$$aMale
000140037 650_2 $$2MeSH$$aMiddle Aged
000140037 650_2 $$2MeSH$$aMotor Activity
000140037 650_2 $$2MeSH$$aMulticenter Studies as Topic
000140037 650_2 $$2MeSH$$aNeuropsychological Tests
000140037 650_2 $$2MeSH$$aOxygen Consumption
000140037 650_2 $$2MeSH$$aPhysical Fitness
000140037 650_2 $$2MeSH$$aTransfer, Psychology
000140037 7001_ $$aTüscher, Oliver$$b1
000140037 7001_ $$0P:(DE-2719)2000026$$aTeipel, Stefan$$b2$$udzne
000140037 7001_ $$aMierau, Andreas$$b3
000140037 7001_ $$aStrüder, Heiko$$b4
000140037 7001_ $$aDrzezga, Alexander$$b5
000140037 7001_ $$aBaier, Bernhard$$b6
000140037 7001_ $$aBinder, Harald$$b7
000140037 7001_ $$aFellgiebel, Andreas$$b8
000140037 7001_ $$agroup, German AgeGain study$$b9
000140037 7001_ $$aFellgiebel, Andreas$$b10
000140037 7001_ $$aTüscher, Oliver$$b11
000140037 7001_ $$aBaier, Bernhard$$b12
000140037 7001_ $$aWolf, Dominik$$b13
000140037 7001_ $$aKollmann, Bianca$$b14
000140037 7001_ $$aFischer, Florian$$b15
000140037 7001_ $$aSebastian, Alexandra$$b16
000140037 7001_ $$aStrüder, Heiko$$b17
000140037 7001_ $$aMierau, Andreas$$b18
000140037 7001_ $$aKnaepen, Kristel$$b19
000140037 7001_ $$aRiedel, David$$b20
000140037 7001_ $$0P:(DE-HGF)0$$aDrzezga, Alexander$$b21
000140037 7001_ $$0P:(DE-HGF)0$$aTeipel, Stefan$$b22
000140037 7001_ $$0P:(DE-HGF)0$$aBrüggen, Katharina$$b23
000140037 7001_ $$0P:(DE-HGF)0$$aHenf, Judith$$b24
000140037 7001_ $$0P:(DE-HGF)0$$aLau, Esther$$b25
000140037 7001_ $$aBinder, Harald$$b26
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