TY  - JOUR
AU  - Wolf, Dominik
AU  - Tüscher, Oliver
AU  - Teipel, Stefan
AU  - Mierau, Andreas
AU  - Strüder, Heiko
AU  - Drzezga, Alexander
AU  - Baier, Bernhard
AU  - Binder, Harald
AU  - Fellgiebel, Andreas
AU  - group, German AgeGain study
AU  - Fellgiebel, Andreas
AU  - Tüscher, Oliver
AU  - Baier, Bernhard
AU  - Wolf, Dominik
AU  - Kollmann, Bianca
AU  - Fischer, Florian
AU  - Sebastian, Alexandra
AU  - Strüder, Heiko
AU  - Mierau, Andreas
AU  - Knaepen, Kristel
AU  - Riedel, David
AU  - Drzezga, Alexander
AU  - Teipel, Stefan
AU  - Brüggen, Katharina
AU  - Henf, Judith
AU  - Lau, Esther
AU  - Binder, Harald
TI  - Mechanisms and modulators of cognitive training gain transfer in cognitively healthy aging: study protocol of the AgeGain study.
JO  - Trials
VL  - 19
IS  - 1
SN  - 1745-6215
CY  - London
PB  - BioMed Central
M1  - DZNE-2020-06359
SP  - 337
PY  - 2018
AB  - Cognitively healthy older people can increase their performance in cognitive tasks through training. However, training effects are mostly limited to the trained task; thus, training effects only poorly transfer to untrained tasks or other contexts, which contributes to reduced adaptation abilities in aging. Stabilizing transfer capabilities in aging would increase the chance of persistent high performance in activities of daily living including longer independency, and prolonged active participation in social life. The trial AgeGain aims at elaborating the physiological brain mechanisms of transfer in aging and supposed major modulators of transfer capability, especially physical activity, cerebral vascular lesions, and amyloid burden.This 4-year interventional, multicenter, phase 2a cognitive and physical training study will enroll 237 cognitively healthy older subjects in four recruiting centers. The primary endpoint of this trial is the prediction of transfer of cognitive training gains. Secondary endpoints are the structural connectivity of the corpus callosum, Default Mode Network activity, brain-derived neurotrophic factors, motor fitness, and maximal oxygen uptake.Cognitive transfer allows making use of cognitive training gains in everyday life. Thus, maintenance of transfer capability with aging increases the chance of persistent self-guidance and prolonged active participation in social life, which may support a good quality of life. The AgeGain study aims at identifying older people who will most benefit from cognitive training. It will increase the understanding of the neurobiological mechanisms of transfer in aging and will help in determining the impact of physical activity and sport as well as pathologic factors (such as cerebrovascular disease and amyloid load) on transfer capability.German Clinical Trials Register (DRKS), ID: DRKS00013077 . Registered on 19 November 2017.
KW  - Age Factors
KW  - Brain: diagnostic imaging
KW  - Brain: metabolism
KW  - Brain: physiology
KW  - Brain-Derived Neurotrophic Factor: metabolism
KW  - Clinical Trials, Phase II as Topic
KW  - Cognition
KW  - Cognitive Aging: psychology
KW  - Cognitive Behavioral Therapy: methods
KW  - Corpus Callosum: diagnostic imaging
KW  - Corpus Callosum: physiology
KW  - Exercise Test
KW  - Female
KW  - Germany
KW  - Healthy Aging: psychology
KW  - Humans
KW  - Longitudinal Studies
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Middle Aged
KW  - Motor Activity
KW  - Multicenter Studies as Topic
KW  - Neuropsychological Tests
KW  - Oxygen Consumption
KW  - Physical Fitness
KW  - Transfer, Psychology
KW  - Brain-Derived Neurotrophic Factor (NLM Chemicals)
KW  - BDNF protein, human (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:29945638
C2  - pmc:PMC6020358
DO  - DOI:10.1186/s13063-018-2688-2
UR  - https://pub.dzne.de/record/140037
ER  -