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@ARTICLE{Wolf:140037,
      author       = {Wolf, Dominik and Tüscher, Oliver and Teipel, Stefan and
                      Mierau, Andreas and Strüder, Heiko and Drzezga, Alexander
                      and Baier, Bernhard and Binder, Harald and Fellgiebel,
                      Andreas and group, German AgeGain study and Fellgiebel,
                      Andreas and Tüscher, Oliver and Baier, Bernhard and Wolf,
                      Dominik and Kollmann, Bianca and Fischer, Florian and
                      Sebastian, Alexandra and Strüder, Heiko and Mierau, Andreas
                      and Knaepen, Kristel and Riedel, David and Drzezga,
                      Alexander and Teipel, Stefan and Brüggen, Katharina and
                      Henf, Judith and Lau, Esther and Binder, Harald},
      title        = {{M}echanisms and modulators of cognitive training gain
                      transfer in cognitively healthy aging: study protocol of the
                      {A}ge{G}ain study.},
      journal      = {Trials},
      volume       = {19},
      number       = {1},
      issn         = {1745-6215},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {DZNE-2020-06359},
      pages        = {337},
      year         = {2018},
      abstract     = {Cognitively healthy older people can increase their
                      performance in cognitive tasks through training. However,
                      training effects are mostly limited to the trained task;
                      thus, training effects only poorly transfer to untrained
                      tasks or other contexts, which contributes to reduced
                      adaptation abilities in aging. Stabilizing transfer
                      capabilities in aging would increase the chance of
                      persistent high performance in activities of daily living
                      including longer independency, and prolonged active
                      participation in social life. The trial AgeGain aims at
                      elaborating the physiological brain mechanisms of transfer
                      in aging and supposed major modulators of transfer
                      capability, especially physical activity, cerebral vascular
                      lesions, and amyloid burden.This 4-year interventional,
                      multicenter, phase 2a cognitive and physical training study
                      will enroll 237 cognitively healthy older subjects in four
                      recruiting centers. The primary endpoint of this trial is
                      the prediction of transfer of cognitive training gains.
                      Secondary endpoints are the structural connectivity of the
                      corpus callosum, Default Mode Network activity,
                      brain-derived neurotrophic factors, motor fitness, and
                      maximal oxygen uptake.Cognitive transfer allows making use
                      of cognitive training gains in everyday life. Thus,
                      maintenance of transfer capability with aging increases the
                      chance of persistent self-guidance and prolonged active
                      participation in social life, which may support a good
                      quality of life. The AgeGain study aims at identifying older
                      people who will most benefit from cognitive training. It
                      will increase the understanding of the neurobiological
                      mechanisms of transfer in aging and will help in determining
                      the impact of physical activity and sport as well as
                      pathologic factors (such as cerebrovascular disease and
                      amyloid load) on transfer capability.German Clinical Trials
                      Register (DRKS), ID: DRKS00013077 . Registered on 19
                      November 2017.},
      keywords     = {Age Factors / Brain: diagnostic imaging / Brain: metabolism
                      / Brain: physiology / Brain-Derived Neurotrophic Factor:
                      metabolism / Clinical Trials, Phase II as Topic / Cognition
                      / Cognitive Aging: psychology / Cognitive Behavioral
                      Therapy: methods / Corpus Callosum: diagnostic imaging /
                      Corpus Callosum: physiology / Exercise Test / Female /
                      Germany / Healthy Aging: psychology / Humans / Longitudinal
                      Studies / Magnetic Resonance Imaging / Male / Middle Aged /
                      Motor Activity / Multicenter Studies as Topic /
                      Neuropsychological Tests / Oxygen Consumption / Physical
                      Fitness / Transfer, Psychology / Brain-Derived Neurotrophic
                      Factor (NLM Chemicals) / BDNF protein, human (NLM
                      Chemicals)},
      cin          = {AG Teipel},
      ddc          = {610},
      cid          = {I:(DE-2719)1510100},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29945638},
      pmc          = {pmc:PMC6020358},
      doi          = {10.1186/s13063-018-2688-2},
      url          = {https://pub.dzne.de/record/140037},
}