Home > Publications Database > Mechanisms and modulators of cognitive training gain transfer in cognitively healthy aging: study protocol of the AgeGain study. > print

001     140037
005     20240504120051.0
024 7 _ |a 10.1186/s13063-018-2688-2
|2 doi
024 7 _ |a pmid:29945638
|2 pmid
024 7 _ |a pmc:PMC6020358
|2 pmc
024 7 _ |a 1468-6694
|2 ISSN
024 7 _ |a 1468-6708
|2 ISSN
024 7 _ |a 1745-6215
|2 ISSN
024 7 _ |a altmetric:44990416
|2 altmetric
037 _ _ |a DZNE-2020-06359
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Wolf, Dominik
|0 P:(DE-HGF)0
|b 0
|e Corresponding author
245 _ _ |a Mechanisms and modulators of cognitive training gain transfer in cognitively healthy aging: study protocol of the AgeGain study.
260 _ _ |a London
|c 2018
|b BioMed Central
264 _ 1 |3 online
|2 Crossref
|b Springer Science and Business Media LLC
|c 2018-06-27
264 _ 1 |3 print
|2 Crossref
|b Springer Science and Business Media LLC
|c 2018-12-01
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1714744833_31
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a Cognitively healthy older people can increase their performance in cognitive tasks through training. However, training effects are mostly limited to the trained task; thus, training effects only poorly transfer to untrained tasks or other contexts, which contributes to reduced adaptation abilities in aging. Stabilizing transfer capabilities in aging would increase the chance of persistent high performance in activities of daily living including longer independency, and prolonged active participation in social life. The trial AgeGain aims at elaborating the physiological brain mechanisms of transfer in aging and supposed major modulators of transfer capability, especially physical activity, cerebral vascular lesions, and amyloid burden.This 4-year interventional, multicenter, phase 2a cognitive and physical training study will enroll 237 cognitively healthy older subjects in four recruiting centers. The primary endpoint of this trial is the prediction of transfer of cognitive training gains. Secondary endpoints are the structural connectivity of the corpus callosum, Default Mode Network activity, brain-derived neurotrophic factors, motor fitness, and maximal oxygen uptake.Cognitive transfer allows making use of cognitive training gains in everyday life. Thus, maintenance of transfer capability with aging increases the chance of persistent self-guidance and prolonged active participation in social life, which may support a good quality of life. The AgeGain study aims at identifying older people who will most benefit from cognitive training. It will increase the understanding of the neurobiological mechanisms of transfer in aging and will help in determining the impact of physical activity and sport as well as pathologic factors (such as cerebrovascular disease and amyloid load) on transfer capability.German Clinical Trials Register (DRKS), ID: DRKS00013077 . Registered on 19 November 2017.
536 _ _ |a 344 - Clinical and Health Care Research (POF3-344)
|0 G:(DE-HGF)POF3-344
|c POF3-344
|f POF III
|x 0
542 _ _ |i 2018-06-27
|2 Crossref
|u http://creativecommons.org/licenses/by/4.0/
588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 7 |a Brain-Derived Neurotrophic Factor
|2 NLM Chemicals
650 _ 7 |a BDNF protein, human
|0 7171WSG8A2
|2 NLM Chemicals
650 _ 2 |a Age Factors
|2 MeSH
650 _ 2 |a Brain: diagnostic imaging
|2 MeSH
650 _ 2 |a Brain: metabolism
|2 MeSH
650 _ 2 |a Brain: physiology
|2 MeSH
650 _ 2 |a Brain-Derived Neurotrophic Factor: metabolism
|2 MeSH
650 _ 2 |a Clinical Trials, Phase II as Topic
|2 MeSH
650 _ 2 |a Cognition
|2 MeSH
650 _ 2 |a Cognitive Aging: psychology
|2 MeSH
650 _ 2 |a Cognitive Behavioral Therapy: methods
|2 MeSH
650 _ 2 |a Corpus Callosum: diagnostic imaging
|2 MeSH
650 _ 2 |a Corpus Callosum: physiology
|2 MeSH
650 _ 2 |a Exercise Test
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Germany
|2 MeSH
650 _ 2 |a Healthy Aging: psychology
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Longitudinal Studies
|2 MeSH
650 _ 2 |a Magnetic Resonance Imaging
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Motor Activity
|2 MeSH
650 _ 2 |a Multicenter Studies as Topic
|2 MeSH
650 _ 2 |a Neuropsychological Tests
|2 MeSH
650 _ 2 |a Oxygen Consumption
|2 MeSH
650 _ 2 |a Physical Fitness
|2 MeSH
650 _ 2 |a Transfer, Psychology
|2 MeSH
700 1 _ |a Tüscher, Oliver
|b 1
700 1 _ |a Teipel, Stefan
|0 P:(DE-2719)2000026
|b 2
|u dzne
700 1 _ |a Mierau, Andreas
|b 3
700 1 _ |a Strüder, Heiko
|b 4
700 1 _ |a Drzezga, Alexander
|b 5
700 1 _ |a Baier, Bernhard
|b 6
700 1 _ |a Binder, Harald
|b 7
700 1 _ |a Fellgiebel, Andreas
|b 8
700 1 _ |a group, German AgeGain study
|b 9
700 1 _ |a Fellgiebel, Andreas
|b 10
700 1 _ |a Tüscher, Oliver
|b 11
700 1 _ |a Baier, Bernhard
|b 12
700 1 _ |a Wolf, Dominik
|b 13
700 1 _ |a Kollmann, Bianca
|b 14
700 1 _ |a Fischer, Florian
|b 15
700 1 _ |a Sebastian, Alexandra
|b 16
700 1 _ |a Strüder, Heiko
|b 17
700 1 _ |a Mierau, Andreas
|b 18
700 1 _ |a Knaepen, Kristel
|b 19
700 1 _ |a Riedel, David
|b 20
700 1 _ |a Drzezga, Alexander
|0 P:(DE-HGF)0
|b 21
700 1 _ |a Teipel, Stefan
|0 P:(DE-HGF)0
|b 22
700 1 _ |a Brüggen, Katharina
|0 P:(DE-HGF)0
|b 23
700 1 _ |a Henf, Judith
|0 P:(DE-HGF)0
|b 24
700 1 _ |a Lau, Esther
|0 P:(DE-HGF)0
|b 25
700 1 _ |a Binder, Harald
|b 26
773 1 8 |a 10.1186/s13063-018-2688-2
|b : Springer Science and Business Media LLC, 2018-06-27
|n 1
|p 337
|3 journal-article
|2 Crossref
|t Trials
|v 19
|y 2018
|x 1745-6215
773 _ _ |a 10.1186/s13063-018-2688-2
|g Vol. 19, no. 1, p. 337
|0 PERI:(DE-600)2040523-6
|n 1
|q 19:1<337
|p 337
|t Trials
|v 19
|y 2018
|x 1745-6215
856 4 _ |y OpenAccess
|u https://pub.dzne.de/record/140037/files/DZNE-2020-06359.pdf
856 4 _ |y OpenAccess
|x pdfa
|u https://pub.dzne.de/record/140037/files/DZNE-2020-06359.pdf?subformat=pdfa
856 7 _ |2 Pubmed Central
|u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020358
909 C O |o oai:pub.dzne.de:140037
|p openaire
|p open_access
|p VDB
|p driver
|p dnbdelivery
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 2
|6 P:(DE-2719)2000026
913 1 _ |a DE-HGF
|b Gesundheit
|l Erkrankungen des Nervensystems
|1 G:(DE-HGF)POF3-340
|0 G:(DE-HGF)POF3-344
|3 G:(DE-HGF)POF3
|2 G:(DE-HGF)POF3-300
|4 G:(DE-HGF)POF
|v Clinical and Health Care Research
|x 0
914 1 _ |y 2018
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
|d 2022-11-25
915 _ _ |a Creative Commons Attribution CC BY (No Version)
|0 LIC:(DE-HGF)CCBYNV
|2 V:(DE-HGF)
|b DOAJ
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0600
|2 StatID
|b Ebsco Academic Search
|d 2022-11-25
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b TRIALS : 2021
|d 2022-11-25
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0501
|2 StatID
|b DOAJ Seal
|d 2018-09-24T10:24:34Z
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0500
|2 StatID
|b DOAJ
|d 2018-09-24T10:24:34Z
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
|d 2022-11-25
915 _ _ |a IF < 5
|0 StatID:(DE-HGF)9900
|2 StatID
|d 2022-11-25
915 _ _ |a OpenAccess
|0 StatID:(DE-HGF)0510
|2 StatID
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b ASC
|d 2022-11-25
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
|d 2022-11-25
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1110
|2 StatID
|b Current Contents - Clinical Medicine
|d 2022-11-25
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
|d 2022-11-25
920 1 _ |0 I:(DE-2719)1510100
|k AG Teipel
|l Clinical Dementia Research (Rostock /Greifswald)
|x 0
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a UNRESTRICTED
980 _ _ |a I:(DE-2719)1510100
980 1 _ |a FullTexts
999 C 5 |9 -- missing cx lookup --
|a 10.1097/01.JGP.0000192501.03069.bc
|2 Crossref
|o 10.1097/01.JGP.0000192501.03069.bc
999 C 5 |9 -- missing cx lookup --
|a 10.1097/JGP.0b013e318030255f
|2 Crossref
|o 10.1097/JGP.0b013e318030255f
999 C 5 |9 -- missing cx lookup --
|a 10.1037/0882-7974.17.2.179
|2 Crossref
|o 10.1037/0882-7974.17.2.179
999 C 5 |9 -- missing cx lookup --
|a 10.1001/jama.288.18.2271
|2 Crossref
|o 10.1001/jama.288.18.2271
999 C 5 |9 -- missing cx lookup --
|a 10.1126/science.1155466
|2 Crossref
|o 10.1126/science.1155466
999 C 5 |9 -- missing cx lookup --
|a 10.1037/a0014296
|2 Crossref
|o 10.1037/a0014296
999 C 5 |9 -- missing cx lookup --
|a 10.1159/000065259
|2 Crossref
|o 10.1159/000065259
999 C 5 |9 -- missing cx lookup --
|a 10.1076/anec.10.3.202.16452
|2 Crossref
|o 10.1076/anec.10.3.202.16452
999 C 5 |9 -- missing cx lookup --
|a 10.3389/fnagi.2010.00027
|2 Crossref
|o 10.3389/fnagi.2010.00027
999 C 5 |y 2010
|2 Crossref
|o BD Blume 2010
999 C 5 |9 -- missing cx lookup --
|a 10.1002/hbm.22177
|2 Crossref
|o 10.1002/hbm.22177
999 C 5 |y 2005
|2 Crossref
|t Cognitive neuroscience of aging
|o SM Daselaar Cognitive neuroscience of aging 2005
999 C 5 |9 -- missing cx lookup --
|a 10.1093/cercor/bhi020
|2 Crossref
|o 10.1093/cercor/bhi020
999 C 5 |9 -- missing cx lookup --
|a 10.1002/hbm.22119
|2 Crossref
|o 10.1002/hbm.22119
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.neuroimage.2010.08.052
|2 Crossref
|o 10.1016/j.neuroimage.2010.08.052
999 C 5 |9 -- missing cx lookup --
|a 10.1007/s11065-009-9119-9
|2 Crossref
|o 10.1007/s11065-009-9119-9
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.neurobiolaging.2013.03.013
|2 Crossref
|o 10.1016/j.neurobiolaging.2013.03.013
999 C 5 |9 -- missing cx lookup --
|a 10.1111/1467-9280.t01-1-01430
|2 Crossref
|o 10.1111/1467-9280.t01-1-01430
999 C 5 |9 -- missing cx lookup --
|a 10.1212/WNL.0b013e3181f88359
|2 Crossref
|o 10.1212/WNL.0b013e3181f88359
999 C 5 |9 -- missing cx lookup --
|a 10.1093/gerona/61.11.1166
|2 Crossref
|o 10.1093/gerona/61.11.1166
999 C 5 |9 -- missing cx lookup --
|a 10.1073/pnas.0400266101
|2 Crossref
|o 10.1073/pnas.0400266101
999 C 5 |9 -- missing cx lookup --
|a 10.1093/gerona/glq038
|2 Crossref
|o 10.1093/gerona/glq038
999 C 5 |9 -- missing cx lookup --
|a 10.1002/hipo.20547
|2 Crossref
|o 10.1002/hipo.20547
999 C 5 |9 -- missing cx lookup --
|a 10.1073/pnas.0611721104
|2 Crossref
|o 10.1073/pnas.0611721104
999 C 5 |9 -- missing cx lookup --
|a 10.3389/fnagi.2010.00023
|2 Crossref
|o 10.3389/fnagi.2010.00023
999 C 5 |9 -- missing cx lookup --
|a 10.1016/S0166-2236(02)02143-4
|2 Crossref
|o 10.1016/S0166-2236(02)02143-4
999 C 5 |9 -- missing cx lookup --
|a 10.1111/j.1365-2826.2011.02266.x
|2 Crossref
|o 10.1111/j.1365-2826.2011.02266.x
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.neuroscience.2008.03.037
|2 Crossref
|o 10.1016/j.neuroscience.2008.03.037
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.psyneuen.2010.07.012
|2 Crossref
|o 10.1016/j.psyneuen.2010.07.012
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.brainres.2006.08.105
|2 Crossref
|o 10.1016/j.brainres.2006.08.105
999 C 5 |9 -- missing cx lookup --
|a 10.1113/expphysiol.2009.048512
|2 Crossref
|o 10.1113/expphysiol.2009.048512
999 C 5 |y 2008
|2 Crossref
|o J Zoladz 2008
999 C 5 |9 -- missing cx lookup --
|a 10.1073/pnas.1015950108
|2 Crossref
|o 10.1073/pnas.1015950108
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.neuroimage.2011.08.032
|2 Crossref
|o 10.1016/j.neuroimage.2011.08.032
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.neuropsychologia.2010.01.005
|2 Crossref
|o 10.1016/j.neuropsychologia.2010.01.005
999 C 5 |9 -- missing cx lookup --
|a 10.1001/archinternmed.2009.494
|2 Crossref
|o 10.1001/archinternmed.2009.494
999 C 5 |9 -- missing cx lookup --
|a 10.1249/mss.0b013e318060111f
|2 Crossref
|o 10.1249/mss.0b013e318060111f
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.neurobiolaging.2011.05.010
|2 Crossref
|o 10.1016/j.neurobiolaging.2011.05.010
999 C 5 |9 -- missing cx lookup --
|a 10.1037/a0025371
|2 Crossref
|o 10.1037/a0025371
999 C 5 |9 -- missing cx lookup --
|a 10.3389/fnhum.2011.00026
|2 Crossref
|o 10.3389/fnhum.2011.00026
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.neubiorev.2013.01.028
|2 Crossref
|o 10.1016/j.neubiorev.2013.01.028
999 C 5 |9 -- missing cx lookup --
|a 10.1038/nrn1849
|2 Crossref
|o 10.1038/nrn1849
999 C 5 |9 -- missing cx lookup --
|a 10.1155/2012/823285
|2 Crossref
|o 10.1155/2012/823285
999 C 5 |9 -- missing cx lookup --
|a 10.1101/lm.026534.112
|2 Crossref
|o 10.1101/lm.026534.112
999 C 5 |9 -- missing cx lookup --
|a 10.1016/S1474-4422(17)30077-7
|2 Crossref
|o 10.1016/S1474-4422(17)30077-7
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.neuroscience.2013.11.026
|2 Crossref
|o 10.1016/j.neuroscience.2013.11.026
999 C 5 |9 -- missing cx lookup --
|a 10.1159/000100355
|2 Crossref
|o 10.1159/000100355
999 C 5 |9 -- missing cx lookup --
|a 10.1007/s12017-009-8091-0
|2 Crossref
|o 10.1007/s12017-009-8091-0
999 C 5 |9 -- missing cx lookup --
|a 10.1093/brain/awm238
|2 Crossref
|o 10.1093/brain/awm238
999 C 5 |9 -- missing cx lookup --
|a 10.1093/brain/awp062
|2 Crossref
|o 10.1093/brain/awp062
999 C 5 |9 -- missing cx lookup --
|a 10.1523/JNEUROSCI.2462-12.2012
|2 Crossref
|o 10.1523/JNEUROSCI.2462-12.2012
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.neuroimage.2012.06.074
|2 Crossref
|o 10.1016/j.neuroimage.2012.06.074
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.neurobiolaging.2012.08.018
|2 Crossref
|o 10.1016/j.neurobiolaging.2012.08.018
999 C 5 |2 Crossref
|o
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.neuroimage.2009.10.067
|2 Crossref
|o 10.1016/j.neuroimage.2009.10.067
999 C 5 |y 1997
|2 Crossref
|t DIA-X Interviews (M-CIDI)
|o H Wittchen DIA-X Interviews (M-CIDI) 1997
999 C 5 |y 1997
|2 Crossref
|t Internationale Diagnosen-Checklisten für DSM-IV und ICD-10; IDCL
|o W Hiller Internationale Diagnosen-Checklisten für DSM-IV und ICD-10; IDCL 1997
999 C 5 |y 2001
|2 Crossref
|t Handbuch zum Programmpaket COGPACK, Version 7.6
|o K Marker Handbuch zum Programmpaket COGPACK, Version 7.6 2001
999 C 5 |y 1962
|2 Crossref
|t Achievement Measure System (Leistungs-Pruef-System/LPS)
|o W Horn Achievement Measure System (Leistungs-Pruef-System/LPS) 1962
999 C 5 |9 -- missing cx lookup --
|a 10.1098/rstb.1982.0082
|2 Crossref
|o 10.1098/rstb.1982.0082
999 C 5 |9 -- missing cx lookup --
|a 10.3758/s13428-012-0224-y
|2 Crossref
|o 10.3758/s13428-012-0224-y
999 C 5 |9 -- missing cx lookup --
|a 10.3758/s13421-012-0280-7
|2 Crossref
|o 10.3758/s13421-012-0280-7
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.neuroimage.2012.09.020
|2 Crossref
|o 10.1016/j.neuroimage.2012.09.020
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.jneumeth.2007.01.026
|2 Crossref
|o 10.1016/j.jneumeth.2007.01.026
999 C 5 |9 -- missing cx lookup --
|a 10.1093/bioinformatics/btx408
|2 Crossref
|o 10.1093/bioinformatics/btx408
999 C 5 |9 -- missing cx lookup --
|a 10.1093/brain/awr066
|2 Crossref
|o 10.1093/brain/awr066
999 C 5 |9 -- missing cx lookup --
|a 10.1007/978-1-4614-3293-7
|2 Crossref
|o 10.1007/978-1-4614-3293-7

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21