000140045 001__ 140045
000140045 005__ 20240529143839.0
000140045 0247_ $$2doi$$a10.1172/JCI95305
000140045 0247_ $$2pmid$$apmid:29634489
000140045 0247_ $$2pmc$$apmc:PMC6025970
000140045 0247_ $$2ISSN$$a0021-9738
000140045 0247_ $$2ISSN$$a1558-8238
000140045 0247_ $$2altmetric$$aaltmetric:37241678
000140045 037__ $$aDZNE-2020-06367
000140045 041__ $$aEnglish
000140045 082__ $$a610
000140045 1001_ $$aKälin, Stefanie$$b0
000140045 245__ $$aCNS myeloid cells critically regulate heat hyperalgesia.
000140045 260__ $$aAnn Arbor, Mich.$$bASCJ$$c2018
000140045 264_1 $$2Crossref$$3online$$bAmerican Society for Clinical Investigation$$c2018-05-21
000140045 264_1 $$2Crossref$$3print$$bAmerican Society for Clinical Investigation$$c2018-07-02
000140045 3367_ $$2DRIVER$$aarticle
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000140045 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1714744039_29
000140045 3367_ $$2BibTeX$$aARTICLE
000140045 3367_ $$2ORCID$$aJOURNAL_ARTICLE
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000140045 520__ $$aActivation of non-neuronal microglia is thought to play a causal role in spinal processing of neuropathic pain. To specifically investigate microglia-mediated effects in a model of neuropathic pain and overcome the methodological limitations of previous approaches exploring microglia function upon nerve injury, we selectively ablated resident microglia by intracerebroventricular ganciclovir infusion into male CD11b-HSVTK-transgenic mice, which was followed by a rapid, complete, and persistent (23 weeks) repopulation of the CNS by peripheral myeloid cells. In repopulated mice that underwent sciatic nerve injury, we observed a normal response to mechanical stimuli, but an absence of thermal hypersensitivity ipsilateral to the injured nerve. Furthermore, we found that neuronal expression of calcitonin gene-related peptide (CGRP), which is a marker of neurons essential for heat responses, was diminished in the dorsal horn of the spinal cord in repopulated mice. These findings identify distinct mechanisms for heat and mechanical hypersensitivity and highlight a crucial contribution of CNS myeloid cells in the facilitation of noxious heat.
000140045 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
000140045 588__ $$aDataset connected to CrossRef, PubMed,
000140045 650_7 $$2NLM Chemicals$$aPeptide Fragments
000140045 650_7 $$2NLM Chemicals$$acalcitonin gene related peptide (1-7)
000140045 650_7 $$0JHB2QIZ69Z$$2NLM Chemicals$$aCalcitonin Gene-Related Peptide
000140045 650_2 $$2MeSH$$aAnimals
000140045 650_2 $$2MeSH$$aCalcitonin Gene-Related Peptide: physiology
000140045 650_2 $$2MeSH$$aCentral Nervous System: pathology
000140045 650_2 $$2MeSH$$aCentral Nervous System: physiopathology
000140045 650_2 $$2MeSH$$aHot Temperature
000140045 650_2 $$2MeSH$$aHyperalgesia: pathology
000140045 650_2 $$2MeSH$$aHyperalgesia: physiopathology
000140045 650_2 $$2MeSH$$aMale
000140045 650_2 $$2MeSH$$aMice
000140045 650_2 $$2MeSH$$aMice, Inbred C57BL
000140045 650_2 $$2MeSH$$aMice, Transgenic
000140045 650_2 $$2MeSH$$aMicroglia: cytology
000140045 650_2 $$2MeSH$$aMicroglia: physiology
000140045 650_2 $$2MeSH$$aMyeloid Cells: pathology
000140045 650_2 $$2MeSH$$aMyeloid Cells: physiology
000140045 650_2 $$2MeSH$$aNeuralgia: pathology
000140045 650_2 $$2MeSH$$aNeuralgia: physiopathology
000140045 650_2 $$2MeSH$$aPeptide Fragments: physiology
000140045 650_2 $$2MeSH$$aPeripheral Nerve Injuries: pathology
000140045 650_2 $$2MeSH$$aPeripheral Nerve Injuries: physiopathology
000140045 650_2 $$2MeSH$$aPeripheral Nerves: pathology
000140045 650_2 $$2MeSH$$aPeripheral Nerves: physiopathology
000140045 650_2 $$2MeSH$$aSpinal Cord Dorsal Horn: pathology
000140045 650_2 $$2MeSH$$aSpinal Cord Dorsal Horn: physiopathology
000140045 7001_ $$aMiller, Kelly R$$b1
000140045 7001_ $$aKälin, Roland E$$b2
000140045 7001_ $$aJendrach, Marina$$b3
000140045 7001_ $$aWitzel, Christian$$b4
000140045 7001_ $$0P:(DE-2719)2812386$$aHeppner, Frank L$$b5$$eLast author$$udzne
000140045 77318 $$2Crossref$$3journal-article$$a10.1172/jci95305$$b : American Society for Clinical Investigation, 2018-05-21$$n7$$p2774-2786$$tJournal of Clinical Investigation$$v128$$x0021-9738$$y2018
000140045 773__ $$0PERI:(DE-600)2018375-6$$a10.1172/JCI95305$$gVol. 128, no. 7, p. 2774 - 2786$$n7$$p2774-2786$$q128:7<2774 - 2786$$tThe journal of clinical investigation$$v128$$x0021-9738$$y2018
000140045 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025970
000140045 8564_ $$uhttps://pub.dzne.de/record/140045/files/DZNE-2020-06367_Restricted.pdf
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000140045 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812386$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b5$$kDZNE
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000140045 9141_ $$y2018
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