Home > Publications Database > CNS myeloid cells critically regulate heat hyperalgesia. > print

001     140045
005     20240529143839.0
024 7 _ |a 10.1172/JCI95305
|2 doi
024 7 _ |a pmid:29634489
|2 pmid
024 7 _ |a pmc:PMC6025970
|2 pmc
024 7 _ |a 0021-9738
|2 ISSN
024 7 _ |a 1558-8238
|2 ISSN
024 7 _ |a altmetric:37241678
|2 altmetric
037 _ _ |a DZNE-2020-06367
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Kälin, Stefanie
|b 0
245 _ _ |a CNS myeloid cells critically regulate heat hyperalgesia.
260 _ _ |a Ann Arbor, Mich.
|c 2018
|b ASCJ
264 _ 1 |3 online
|2 Crossref
|b American Society for Clinical Investigation
|c 2018-05-21
264 _ 1 |3 print
|2 Crossref
|b American Society for Clinical Investigation
|c 2018-07-02
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1714744039_29
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a Activation of non-neuronal microglia is thought to play a causal role in spinal processing of neuropathic pain. To specifically investigate microglia-mediated effects in a model of neuropathic pain and overcome the methodological limitations of previous approaches exploring microglia function upon nerve injury, we selectively ablated resident microglia by intracerebroventricular ganciclovir infusion into male CD11b-HSVTK-transgenic mice, which was followed by a rapid, complete, and persistent (23 weeks) repopulation of the CNS by peripheral myeloid cells. In repopulated mice that underwent sciatic nerve injury, we observed a normal response to mechanical stimuli, but an absence of thermal hypersensitivity ipsilateral to the injured nerve. Furthermore, we found that neuronal expression of calcitonin gene-related peptide (CGRP), which is a marker of neurons essential for heat responses, was diminished in the dorsal horn of the spinal cord in repopulated mice. These findings identify distinct mechanisms for heat and mechanical hypersensitivity and highlight a crucial contribution of CNS myeloid cells in the facilitation of noxious heat.
536 _ _ |a 342 - Disease Mechanisms and Model Systems (POF3-342)
|0 G:(DE-HGF)POF3-342
|c POF3-342
|f POF III
|x 0
588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 7 |a Peptide Fragments
|2 NLM Chemicals
650 _ 7 |a calcitonin gene related peptide (1-7)
|2 NLM Chemicals
650 _ 7 |a Calcitonin Gene-Related Peptide
|0 JHB2QIZ69Z
|2 NLM Chemicals
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Calcitonin Gene-Related Peptide: physiology
|2 MeSH
650 _ 2 |a Central Nervous System: pathology
|2 MeSH
650 _ 2 |a Central Nervous System: physiopathology
|2 MeSH
650 _ 2 |a Hot Temperature
|2 MeSH
650 _ 2 |a Hyperalgesia: pathology
|2 MeSH
650 _ 2 |a Hyperalgesia: physiopathology
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Mice, Inbred C57BL
|2 MeSH
650 _ 2 |a Mice, Transgenic
|2 MeSH
650 _ 2 |a Microglia: cytology
|2 MeSH
650 _ 2 |a Microglia: physiology
|2 MeSH
650 _ 2 |a Myeloid Cells: pathology
|2 MeSH
650 _ 2 |a Myeloid Cells: physiology
|2 MeSH
650 _ 2 |a Neuralgia: pathology
|2 MeSH
650 _ 2 |a Neuralgia: physiopathology
|2 MeSH
650 _ 2 |a Peptide Fragments: physiology
|2 MeSH
650 _ 2 |a Peripheral Nerve Injuries: pathology
|2 MeSH
650 _ 2 |a Peripheral Nerve Injuries: physiopathology
|2 MeSH
650 _ 2 |a Peripheral Nerves: pathology
|2 MeSH
650 _ 2 |a Peripheral Nerves: physiopathology
|2 MeSH
650 _ 2 |a Spinal Cord Dorsal Horn: pathology
|2 MeSH
650 _ 2 |a Spinal Cord Dorsal Horn: physiopathology
|2 MeSH
700 1 _ |a Miller, Kelly R
|b 1
700 1 _ |a Kälin, Roland E
|b 2
700 1 _ |a Jendrach, Marina
|b 3
700 1 _ |a Witzel, Christian
|b 4
700 1 _ |a Heppner, Frank L
|0 P:(DE-2719)2812386
|b 5
|e Last author
|u dzne
773 1 8 |a 10.1172/jci95305
|b : American Society for Clinical Investigation, 2018-05-21
|n 7
|p 2774-2786
|3 journal-article
|2 Crossref
|t Journal of Clinical Investigation
|v 128
|y 2018
|x 0021-9738
773 _ _ |a 10.1172/JCI95305
|g Vol. 128, no. 7, p. 2774 - 2786
|0 PERI:(DE-600)2018375-6
|n 7
|q 128:7<2774 - 2786
|p 2774-2786
|t The journal of clinical investigation
|v 128
|y 2018
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856 7 _ |2 Pubmed Central
|u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025970
856 4 _ |u https://pub.dzne.de/record/140045/files/DZNE-2020-06367_Restricted.pdf
856 4 _ |u https://pub.dzne.de/record/140045/files/DZNE-2020-06367_Restricted.pdf?subformat=pdfa
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 5
|6 P:(DE-2719)2812386
913 1 _ |a DE-HGF
|b Gesundheit
|l Erkrankungen des Nervensystems
|1 G:(DE-HGF)POF3-340
|0 G:(DE-HGF)POF3-342
|3 G:(DE-HGF)POF3
|2 G:(DE-HGF)POF3-300
|4 G:(DE-HGF)POF
|v Disease Mechanisms and Model Systems
|x 0
914 1 _ |y 2018
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999 C 5 |9 -- missing cx lookup --
|a 10.1111/j.1471-4159.2006.03746.x
|2 Crossref
|o 10.1111/j.1471-4159.2006.03746.x
999 C 5 |9 -- missing cx lookup --
|a 10.1038/nrn2533
|2 Crossref
|o 10.1038/nrn2533
999 C 5 |9 -- missing cx lookup --
|a 10.1523/JNEUROSCI.1642-11.2011
|2 Crossref
|o 10.1523/JNEUROSCI.1642-11.2011
999 C 5 |9 -- missing cx lookup --
|a 10.1038/nm1177
|2 Crossref
|o 10.1038/nm1177
999 C 5 |9 -- missing cx lookup --
|a 10.1038/nn.2432
|2 Crossref
|o 10.1038/nn.2432
999 C 5 |9 -- missing cx lookup --
|a 10.1073/pnas.1210150109
|2 Crossref
|o 10.1073/pnas.1210150109
999 C 5 |9 -- missing cx lookup --
|a 10.1084/jem.20150479
|2 Crossref
|o 10.1084/jem.20150479
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.neuron.2013.01.030
|2 Crossref
|o 10.1016/j.neuron.2013.01.030
999 C 5 |9 -- missing cx lookup --
|a 10.1006/exnr.1999.7065
|2 Crossref
|o 10.1006/exnr.1999.7065
999 C 5 |9 -- missing cx lookup --
|a 10.1152/physrev.00011.2010
|2 Crossref
|o 10.1152/physrev.00011.2010
999 C 5 |9 -- missing cx lookup --
|a 10.1126/science.1194637
|2 Crossref
|o 10.1126/science.1194637
999 C 5 |9 -- missing cx lookup --
|a 10.1523/JNEUROSCI.3016-07.2007
|2 Crossref
|o 10.1523/JNEUROSCI.3016-07.2007
999 C 5 |9 -- missing cx lookup --
|a 10.1038/nn2015
|2 Crossref
|o 10.1038/nn2015
999 C 5 |9 -- missing cx lookup --
|a 10.1152/physrev.00025.2008
|2 Crossref
|o 10.1152/physrev.00025.2008
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.pain.2010.09.030
|2 Crossref
|o 10.1016/j.pain.2010.09.030
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.cell.2009.09.028
|2 Crossref
|o 10.1016/j.cell.2009.09.028
999 C 5 |9 -- missing cx lookup --
|a 10.1073/pnas.0503264102
|2 Crossref
|o 10.1073/pnas.0503264102
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.neuron.2009.09.033
|2 Crossref
|o 10.1016/j.neuron.2009.09.033
999 C 5 |9 -- missing cx lookup --
|a 10.1124/jpet.103.052407
|2 Crossref
|o 10.1124/jpet.103.052407
999 C 5 |9 -- missing cx lookup --
|a 10.1073/pnas.1331358100
|2 Crossref
|o 10.1073/pnas.1331358100
999 C 5 |y 2010
|2 Crossref
|o Staniland 2010
999 C 5 |9 -- missing cx lookup --
|a 10.1038/nn.3295
|2 Crossref
|o 10.1038/nn.3295
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.expneurol.2010.12.010
|2 Crossref
|o 10.1016/j.expneurol.2010.12.010
999 C 5 |9 -- missing cx lookup --
|a 10.1002/jnr.10709
|2 Crossref
|o 10.1002/jnr.10709
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.neulet.2005.05.047
|2 Crossref
|o 10.1016/j.neulet.2005.05.047
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.neuron.2014.02.040
|2 Crossref
|o 10.1016/j.neuron.2014.02.040
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.immuni.2015.06.012
|2 Crossref
|o 10.1016/j.immuni.2015.06.012
999 C 5 |9 -- missing cx lookup --
|a 10.1017/S1740925X08000100
|2 Crossref
|o 10.1017/S1740925X08000100
999 C 5 |9 -- missing cx lookup --
|a 10.1111/j.1533-2500.2010.00367.x
|2 Crossref
|o 10.1111/j.1533-2500.2010.00367.x
999 C 5 |9 -- missing cx lookup --
|a 10.1523/JNEUROSCI.3338-07.2008
|2 Crossref
|o 10.1523/JNEUROSCI.3338-07.2008
999 C 5 |9 -- missing cx lookup --
|a 10.1038/nature04223
|2 Crossref
|o 10.1038/nature04223
999 C 5 |9 -- missing cx lookup --
|a 10.1038/nn.3599
|2 Crossref
|o 10.1038/nn.3599
999 C 5 |9 -- missing cx lookup --
|a 10.1038/ni.3585
|2 Crossref
|o 10.1038/ni.3585
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.cell.2017.05.018
|2 Crossref
|o 10.1016/j.cell.2017.05.018
999 C 5 |9 -- missing cx lookup --
|a 10.1126/science.aag2590
|2 Crossref
|o 10.1126/science.aag2590
999 C 5 |9 -- missing cx lookup --
|a 10.1523/JNEUROSCI.4158-11.2011
|2 Crossref
|o 10.1523/JNEUROSCI.4158-11.2011
999 C 5 |9 -- missing cx lookup --
|a 10.1523/JNEUROSCI.4363-08.2009
|2 Crossref
|o 10.1523/JNEUROSCI.4363-08.2009
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.neuron.2012.12.023
|2 Crossref
|o 10.1016/j.neuron.2012.12.023
999 C 5 |9 -- missing cx lookup --
|a 10.1002/(SICI)1098-1136(199807)23:3<221::AID-GLIA5>3.0.CO;2-7
|2 Crossref
|o 10.1002/(SICI)1098-1136(199807)23:3<221::AID-GLIA5>3.0.CO;2-7
999 C 5 |9 -- missing cx lookup --
|a 10.1002/cne.2000
|2 Crossref
|o 10.1002/cne.2000
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.tins.2004.12.002
|2 Crossref
|o 10.1016/j.tins.2004.12.002
999 C 5 |9 -- missing cx lookup --
|a 10.1097/00001756-200103260-00025
|2 Crossref
|o 10.1097/00001756-200103260-00025
999 C 5 |9 -- missing cx lookup --
|a 10.1097/NEN.0b013e31819ac71b
|2 Crossref
|o 10.1097/NEN.0b013e31819ac71b
999 C 5 |9 -- missing cx lookup --
|a 10.1016/S0165-0270(98)00100-9
|2 Crossref
|o 10.1016/S0165-0270(98)00100-9
999 C 5 |9 -- missing cx lookup --
|a 10.1016/0165-0270(94)90144-9
|2 Crossref
|o 10.1016/0165-0270(94)90144-9
999 C 5 |9 -- missing cx lookup --
|a 10.1016/0304-3959(88)90026-7
|2 Crossref
|o 10.1016/0304-3959(88)90026-7

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