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@ARTICLE{Mller:140053,
      author       = {Müller, Notger G and Riemer, Martin and Brandt, Lisa and
                      Wolbers, Thomas},
      title        = {{R}epetitive transcranial magnetic stimulation reveals a
                      causal role of the human precuneus in spatial updating.},
      journal      = {Scientific reports},
      volume       = {8},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {DZNE-2020-06375},
      pages        = {10171},
      year         = {2018},
      abstract     = {As we move through an environment, the positions of
                      surrounding objects relative to our body constantly change,
                      with some objects even leaving our field of view. As a
                      consequence, maintaining orientation requires spatial
                      updating, the continuous monitoring of self-motion cues to
                      update external locations within an egocentric frame of
                      reference. While previous research using functional magnetic
                      resonance imaging has implicated the precuneus in spatial
                      updating, direct evidence for this claim is missing. To
                      address this important question, we applied theta burst
                      repetitive transcranial magnetic stimulation (rTMS) over the
                      precuneus to induce a 'virtual lesion'. Following
                      stimulation, participants were tested in a large-scale
                      virtual environment in which they had to use visual
                      self-motion information to keep track of the position of
                      virtual objects. Compared to sham stimulation, rTMS affected
                      working memory traces for object locations. Critically, rTMS
                      further impaired the ability to update these locations
                      whenever participants experienced simulated movement. As
                      this effect could not be explained by working memory
                      deficits alone, we conclude that visual spatial updating
                      relies on the construction of updated representations of
                      egocentric object locations within the precuneus. Together,
                      these findings establish the precuneus as performing key
                      computations for the formation of cognitive maps.},
      keywords     = {Adult / Female / Humans / Male / Parietal Lobe: physiology
                      / Space Perception: physiology / Task Performance and
                      Analysis / Transcranial Magnetic Stimulation / Young Adult},
      cin          = {AG Müller / AG Wolbers},
      ddc          = {600},
      cid          = {I:(DE-2719)1310003 / I:(DE-2719)1310002},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29977007},
      pmc          = {pmc:PMC6033850},
      doi          = {10.1038/s41598-018-28487-7},
      url          = {https://pub.dzne.de/record/140053},
}