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000140054 0247_ $$2doi$$a10.1159/000488481
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000140054 0247_ $$2ISSN$$a1420-8008
000140054 0247_ $$2ISSN$$a1421-9824
000140054 0247_ $$2ISSN$$a2571-7200
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000140054 041__ $$aEnglish
000140054 082__ $$a610
000140054 1001_ $$aAlexopoulos, Panagiotis$$b0
000140054 245__ $$aCerebrospinal Fluid BACE1 Activity and sAβPPβ as Biomarker Candidates of Alzheimer's Disease.
000140054 260__ $$aBasel$$bKarger$$c2018
000140054 264_1 $$2Crossref$$3online$$bS. Karger AG$$c2018-05-22
000140054 264_1 $$2Crossref$$3print$$bS. Karger AG$$c2018-01-01
000140054 264_1 $$2Crossref$$3print$$bS. Karger AG$$c2018-07-10
000140054 3367_ $$2DRIVER$$aarticle
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000140054 3367_ $$2BibTeX$$aARTICLE
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000140054 520__ $$aThe utility of β-site amyloid-β precursor protein (AβPP) cleaving enzyme 1 (BACE1) activity and soluble AβPP β (sAβPPβ) levels in cerebrospinal fluid (CSF) in detecting Alzheimer's disease (AD) is still elusive.BACE1 activity and sAβPPβ concentration were measured in patients with AD dementia (n = 56) and mild cognitive impairment (MCI) due to AD (n = 76) with abnormal routine AD CSF markers, in patients with MCI with normal CSF markers (n = 39), and in controls without preclinical AD (n = 48). In a subsample with available 18F-fluorodeoxyglucose positron emission tomography (FDG PET) data, ordinal regression models were employed to compare the contribution of BACE1 and sAβPPβ to correct diagnostic classification to that of FDG PET.BACE1 activity was significantly higher in patients with MCI due to AD compared to both controls and patients with MCI with normal CSF markers. sAβPPβ did not differ between any of the studied groups. Interestingly, BACE1 activity was not found to be inferior to FDG PET as predictive covariate in differentiating between the diagnostic groups.Further studies using biomarker-underpinned diagnoses are warranted to shed more light on the potential diagnostic utility of BACE1 activity as AD biomarker candidate in MCI.
000140054 536__ $$0G:(DE-HGF)POF3-344$$a344 - Clinical and Health Care Research (POF3-344)$$cPOF3-344$$fPOF III$$x0
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000140054 650_7 $$2NLM Chemicals$$aAmyloid beta-Protein Precursor
000140054 650_7 $$2NLM Chemicals$$aBiomarkers
000140054 650_7 $$2NLM Chemicals$$aRadiopharmaceuticals
000140054 650_7 $$00Z5B2CJX4D$$2NLM Chemicals$$aFluorodeoxyglucose F18
000140054 650_7 $$0EC 3.4.-$$2NLM Chemicals$$aAmyloid Precursor Protein Secretases
000140054 650_7 $$0EC 3.4.23.-$$2NLM Chemicals$$aAspartic Acid Endopeptidases
000140054 650_7 $$0EC 3.4.23.46$$2NLM Chemicals$$aBACE1 protein, human
000140054 650_2 $$2MeSH$$aAged
000140054 650_2 $$2MeSH$$aAlzheimer Disease: cerebrospinal fluid
000140054 650_2 $$2MeSH$$aAlzheimer Disease: diagnosis
000140054 650_2 $$2MeSH$$aAmyloid Precursor Protein Secretases: cerebrospinal fluid
000140054 650_2 $$2MeSH$$aAmyloid beta-Protein Precursor: cerebrospinal fluid
000140054 650_2 $$2MeSH$$aAspartic Acid Endopeptidases: cerebrospinal fluid
000140054 650_2 $$2MeSH$$aBiomarkers: cerebrospinal fluid
000140054 650_2 $$2MeSH$$aCognitive Dysfunction: cerebrospinal fluid
000140054 650_2 $$2MeSH$$aCognitive Dysfunction: diagnosis
000140054 650_2 $$2MeSH$$aDiagnosis, Differential
000140054 650_2 $$2MeSH$$aFemale
000140054 650_2 $$2MeSH$$aFluorodeoxyglucose F18: pharmacology
000140054 650_2 $$2MeSH$$aHumans
000140054 650_2 $$2MeSH$$aMale
000140054 650_2 $$2MeSH$$aMiddle Aged
000140054 650_2 $$2MeSH$$aPositron-Emission Tomography: methods
000140054 650_2 $$2MeSH$$aRadiopharmaceuticals: pharmacology
000140054 7001_ $$aThierjung, Nathalie$$b1
000140054 7001_ $$aGrimmer, Timo$$b2
000140054 7001_ $$aOrtner, Marion$$b3
000140054 7001_ $$aEconomou, Polychronis$$b4
000140054 7001_ $$aAssimakopoulos, Konstantinos$$b5
000140054 7001_ $$aGourzis, Philippos$$b6
000140054 7001_ $$aPolitis, Antonios$$b7
000140054 7001_ $$0P:(DE-2719)2812234$$aPerneczky, Robert$$b8$$eLast author$$udzne
000140054 7001_ $$aInitiative, The Alzheimer’s Disease Neuroimaging$$b9
000140054 77318 $$2Crossref$$3journal-article$$a10.1159/000488481$$b : S. Karger AG, 2018-01-01$$n3-4$$p152-161$$tDementia and Geriatric Cognitive Disorders$$v45$$x1420-8008$$y2018
000140054 773__ $$0PERI:(DE-600)1482186-2$$a10.1159/000488481$$gVol. 45, no. 3-4, p. 152 - 161$$n3-4$$p152-161$$q45:3-4<152 - 161$$tDementia and geriatric cognitive disorders$$v45$$x1420-8008$$y2018
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000140054 9141_ $$y2018
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