TY  - JOUR
AU  - Alexopoulos, Panagiotis
AU  - Thierjung, Nathalie
AU  - Grimmer, Timo
AU  - Ortner, Marion
AU  - Economou, Polychronis
AU  - Assimakopoulos, Konstantinos
AU  - Gourzis, Philippos
AU  - Politis, Antonios
AU  - Perneczky, Robert
AU  - Initiative, The Alzheimer’s Disease Neuroimaging
TI  - Cerebrospinal Fluid BACE1 Activity and sAβPPβ as Biomarker Candidates of Alzheimer's Disease.
JO  - Dementia and geriatric cognitive disorders
VL  - 45
IS  - 3-4
SN  - 1420-8008
CY  - Basel
PB  - Karger
M1  - DZNE-2020-06376
SP  - 152-161
PY  - 2018
AB  - The utility of β-site amyloid-β precursor protein (AβPP) cleaving enzyme 1 (BACE1) activity and soluble AβPP β (sAβPPβ) levels in cerebrospinal fluid (CSF) in detecting Alzheimer's disease (AD) is still elusive.BACE1 activity and sAβPPβ concentration were measured in patients with AD dementia (n = 56) and mild cognitive impairment (MCI) due to AD (n = 76) with abnormal routine AD CSF markers, in patients with MCI with normal CSF markers (n = 39), and in controls without preclinical AD (n = 48). In a subsample with available 18F-fluorodeoxyglucose positron emission tomography (FDG PET) data, ordinal regression models were employed to compare the contribution of BACE1 and sAβPPβ to correct diagnostic classification to that of FDG PET.BACE1 activity was significantly higher in patients with MCI due to AD compared to both controls and patients with MCI with normal CSF markers. sAβPPβ did not differ between any of the studied groups. Interestingly, BACE1 activity was not found to be inferior to FDG PET as predictive covariate in differentiating between the diagnostic groups.Further studies using biomarker-underpinned diagnoses are warranted to shed more light on the potential diagnostic utility of BACE1 activity as AD biomarker candidate in MCI.
KW  - Aged
KW  - Alzheimer Disease: cerebrospinal fluid
KW  - Alzheimer Disease: diagnosis
KW  - Amyloid Precursor Protein Secretases: cerebrospinal fluid
KW  - Amyloid beta-Protein Precursor: cerebrospinal fluid
KW  - Aspartic Acid Endopeptidases: cerebrospinal fluid
KW  - Biomarkers: cerebrospinal fluid
KW  - Cognitive Dysfunction: cerebrospinal fluid
KW  - Cognitive Dysfunction: diagnosis
KW  - Diagnosis, Differential
KW  - Female
KW  - Fluorodeoxyglucose F18: pharmacology
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - Positron-Emission Tomography: methods
KW  - Radiopharmaceuticals: pharmacology
KW  - Amyloid beta-Protein Precursor (NLM Chemicals)
KW  - Biomarkers (NLM Chemicals)
KW  - Radiopharmaceuticals (NLM Chemicals)
KW  - Fluorodeoxyglucose F18 (NLM Chemicals)
KW  - Amyloid Precursor Protein Secretases (NLM Chemicals)
KW  - Aspartic Acid Endopeptidases (NLM Chemicals)
KW  - BACE1 protein, human (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:29788013
DO  - DOI:10.1159/000488481
UR  - https://pub.dzne.de/record/140054
ER  -