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@ARTICLE{Alexopoulos:140054,
      author       = {Alexopoulos, Panagiotis and Thierjung, Nathalie and
                      Grimmer, Timo and Ortner, Marion and Economou, Polychronis
                      and Assimakopoulos, Konstantinos and Gourzis, Philippos and
                      Politis, Antonios and Perneczky, Robert and Initiative, The
                      Alzheimer’s Disease Neuroimaging},
      title        = {{C}erebrospinal {F}luid {BACE}1 {A}ctivity and s{A}β{PP}β
                      as {B}iomarker {C}andidates of {A}lzheimer's {D}isease.},
      journal      = {Dementia and geriatric cognitive disorders},
      volume       = {45},
      number       = {3-4},
      issn         = {1420-8008},
      address      = {Basel},
      publisher    = {Karger},
      reportid     = {DZNE-2020-06376},
      pages        = {152-161},
      year         = {2018},
      abstract     = {The utility of β-site amyloid-β precursor protein (AβPP)
                      cleaving enzyme 1 (BACE1) activity and soluble AβPP β
                      (sAβPPβ) levels in cerebrospinal fluid (CSF) in detecting
                      Alzheimer's disease (AD) is still elusive.BACE1 activity and
                      sAβPPβ concentration were measured in patients with AD
                      dementia (n = 56) and mild cognitive impairment (MCI) due to
                      AD (n = 76) with abnormal routine AD CSF markers, in
                      patients with MCI with normal CSF markers (n = 39), and in
                      controls without preclinical AD (n = 48). In a subsample
                      with available 18F-fluorodeoxyglucose positron emission
                      tomography (FDG PET) data, ordinal regression models were
                      employed to compare the contribution of BACE1 and sAβPPβ
                      to correct diagnostic classification to that of FDG
                      PET.BACE1 activity was significantly higher in patients with
                      MCI due to AD compared to both controls and patients with
                      MCI with normal CSF markers. sAβPPβ did not differ between
                      any of the studied groups. Interestingly, BACE1 activity was
                      not found to be inferior to FDG PET as predictive covariate
                      in differentiating between the diagnostic groups.Further
                      studies using biomarker-underpinned diagnoses are warranted
                      to shed more light on the potential diagnostic utility of
                      BACE1 activity as AD biomarker candidate in MCI.},
      keywords     = {Aged / Alzheimer Disease: cerebrospinal fluid / Alzheimer
                      Disease: diagnosis / Amyloid Precursor Protein Secretases:
                      cerebrospinal fluid / Amyloid beta-Protein Precursor:
                      cerebrospinal fluid / Aspartic Acid Endopeptidases:
                      cerebrospinal fluid / Biomarkers: cerebrospinal fluid /
                      Cognitive Dysfunction: cerebrospinal fluid / Cognitive
                      Dysfunction: diagnosis / Diagnosis, Differential / Female /
                      Fluorodeoxyglucose F18: pharmacology / Humans / Male /
                      Middle Aged / Positron-Emission Tomography: methods /
                      Radiopharmaceuticals: pharmacology / Amyloid beta-Protein
                      Precursor (NLM Chemicals) / Biomarkers (NLM Chemicals) /
                      Radiopharmaceuticals (NLM Chemicals) / Fluorodeoxyglucose
                      F18 (NLM Chemicals) / Amyloid Precursor Protein Secretases
                      (NLM Chemicals) / Aspartic Acid Endopeptidases (NLM
                      Chemicals) / BACE1 protein, human (NLM Chemicals)},
      cin          = {Clinical Dementia Research München},
      ddc          = {610},
      cid          = {I:(DE-2719)1111016},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29788013},
      doi          = {10.1159/000488481},
      url          = {https://pub.dzne.de/record/140054},
}