%0 Journal Article
%A Taipale, Heidi
%A Gomm, Willy
%A Broich, Karl
%A Maier, Wolfgang
%A Tolppanen, Anna-Maija
%A Tanskanen, Antti
%A Tiihonen, Jari
%A Hartikainen, Sirpa
%A Haenisch, Britta
%T Use of Antiepileptic Drugs and Dementia Risk-an Analysis of Finnish Health Register and German Health Insurance Data.
%J Journal of the American Geriatrics Society
%V 66
%N 6
%@ 0002-8614
%C Oxford [u.a.]
%I Wiley-Blackwell
%M DZNE-2020-06410
%P 1123-1129
%D 2018
%X To evaluate the association between regular antiepileptic drug (AED) use and incident dementia.Case-control analysis.Finnish public health register and German health insurance data.Individuals with dementia of any type (German data, N=20,325) and Alzheimer's disease (AD; Finnish data, N=70,718) were matched with up to four control persons without dementia.We analyzed the association between regular AED use and dementia. To address potential protopathic bias, a lag time of 2 years between AED use and dementia diagnosis was introduced. Odds ratios (ORs) were calculated by applying conditional logistic regression, adjusted for potential confounding factors such as comorbidities and polypharmacy.Regular AED use was more frequent in individuals with dementia than controls. Regular use of AEDs was associated with a significantly greater risk of incident dementia (adjusted OR=1.28, 95
%K Aged
%K Aged, 80 and over
%K Anticonvulsants: adverse effects
%K Anticonvulsants: therapeutic use
%K Case-Control Studies
%K Cognition
%K Comorbidity
%K Correlation of Data
%K Dementia: diagnosis
%K Dementia: epidemiology
%K Female
%K Finland: epidemiology
%K Geriatric Assessment: methods
%K Germany: epidemiology
%K Humans
%K Insurance Claim Review: statistics & numerical data
%K Male
%K Registries: statistics & numerical data
%K Risk Factors
%K Anticonvulsants (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29566430
%R 10.1111/jgs.15358
%U https://pub.dzne.de/record/140088