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000140088 037__ $$aDZNE-2020-06410
000140088 041__ $$aEnglish
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000140088 1001_ $$aTaipale, Heidi$$b0
000140088 245__ $$aUse of Antiepileptic Drugs and Dementia Risk-an Analysis of Finnish Health Register and German Health Insurance Data.
000140088 260__ $$aOxford [u.a.]$$bWiley-Blackwell$$c2018
000140088 264_1 $$2Crossref$$3online$$bWiley$$c2018-03-22
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000140088 520__ $$aTo evaluate the association between regular antiepileptic drug (AED) use and incident dementia.Case-control analysis.Finnish public health register and German health insurance data.Individuals with dementia of any type (German data, N=20,325) and Alzheimer's disease (AD; Finnish data, N=70,718) were matched with up to four control persons without dementia.We analyzed the association between regular AED use and dementia. To address potential protopathic bias, a lag time of 2 years between AED use and dementia diagnosis was introduced. Odds ratios (ORs) were calculated by applying conditional logistic regression, adjusted for potential confounding factors such as comorbidities and polypharmacy.Regular AED use was more frequent in individuals with dementia than controls. Regular use of AEDs was associated with a significantly greater risk of incident dementia (adjusted OR=1.28, 95% confidence interval (CI)=1.14-1.44) and AD (adjusted OR=1.15, 95% CI=1.09-1.22) than no AED use. We also detected a trend toward greater risk of dementia with higher exposure. When AEDs with and without known cognitive adverse effects (CAEs) were compared, a significantly greater risk of dementia was observed for substances with known CAEs (dementia: OR=1.59, 95% CI=1.36-1.86; AD: OR=1.19, 95% CI=1.11-1.27).AEDs, especially those with known CAEs, may contribute to incident dementia and AD in older persons.
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000140088 542__ $$2Crossref$$i2018-03-22$$uhttp://doi.wiley.com/10.1002/tdm_license_1.1
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000140088 650_7 $$2NLM Chemicals$$aAnticonvulsants
000140088 650_2 $$2MeSH$$aAged
000140088 650_2 $$2MeSH$$aAged, 80 and over
000140088 650_2 $$2MeSH$$aAnticonvulsants: adverse effects
000140088 650_2 $$2MeSH$$aAnticonvulsants: therapeutic use
000140088 650_2 $$2MeSH$$aCase-Control Studies
000140088 650_2 $$2MeSH$$aCognition
000140088 650_2 $$2MeSH$$aComorbidity
000140088 650_2 $$2MeSH$$aCorrelation of Data
000140088 650_2 $$2MeSH$$aDementia: diagnosis
000140088 650_2 $$2MeSH$$aDementia: epidemiology
000140088 650_2 $$2MeSH$$aFemale
000140088 650_2 $$2MeSH$$aFinland: epidemiology
000140088 650_2 $$2MeSH$$aGeriatric Assessment: methods
000140088 650_2 $$2MeSH$$aGermany: epidemiology
000140088 650_2 $$2MeSH$$aHumans
000140088 650_2 $$2MeSH$$aInsurance Claim Review: statistics & numerical data
000140088 650_2 $$2MeSH$$aMale
000140088 650_2 $$2MeSH$$aRegistries: statistics & numerical data
000140088 650_2 $$2MeSH$$aRisk Factors
000140088 7001_ $$0P:(DE-2719)2811376$$aGomm, Willy$$b1$$udzne
000140088 7001_ $$aBroich, Karl$$b2
000140088 7001_ $$0P:(DE-2719)2000015$$aMaier, Wolfgang$$b3$$udzne
000140088 7001_ $$aTolppanen, Anna-Maija$$b4
000140088 7001_ $$aTanskanen, Antti$$b5
000140088 7001_ $$aTiihonen, Jari$$b6
000140088 7001_ $$aHartikainen, Sirpa$$b7
000140088 7001_ $$0P:(DE-2719)2810511$$aHaenisch, Britta$$b8$$eLast author$$udzne
000140088 77318 $$2Crossref$$3journal-article$$a10.1111/jgs.15358$$b : Wiley, 2018-03-22$$n6$$p1123-1129$$tJournal of the American Geriatrics Society$$v66$$x0002-8614$$y2018
000140088 773__ $$0PERI:(DE-600)2040494-3$$a10.1111/jgs.15358$$gVol. 66, no. 6, p. 1123 - 1129$$n6$$p1123-1129$$q66:6<1123 - 1129$$tJournal of the American Geriatrics Society$$v66$$x0002-8614$$y2018
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