TY  - JOUR
AU  - Taipale, Heidi
AU  - Gomm, Willy
AU  - Broich, Karl
AU  - Maier, Wolfgang
AU  - Tolppanen, Anna-Maija
AU  - Tanskanen, Antti
AU  - Tiihonen, Jari
AU  - Hartikainen, Sirpa
AU  - Haenisch, Britta
TI  - Use of Antiepileptic Drugs and Dementia Risk-an Analysis of Finnish Health Register and German Health Insurance Data.
JO  - Journal of the American Geriatrics Society
VL  - 66
IS  - 6
SN  - 0002-8614
CY  - Oxford [u.a.]
PB  - Wiley-Blackwell
M1  - DZNE-2020-06410
SP  - 1123-1129
PY  - 2018
AB  - To evaluate the association between regular antiepileptic drug (AED) use and incident dementia.Case-control analysis.Finnish public health register and German health insurance data.Individuals with dementia of any type (German data, N=20,325) and Alzheimer's disease (AD; Finnish data, N=70,718) were matched with up to four control persons without dementia.We analyzed the association between regular AED use and dementia. To address potential protopathic bias, a lag time of 2 years between AED use and dementia diagnosis was introduced. Odds ratios (ORs) were calculated by applying conditional logistic regression, adjusted for potential confounding factors such as comorbidities and polypharmacy.Regular AED use was more frequent in individuals with dementia than controls. Regular use of AEDs was associated with a significantly greater risk of incident dementia (adjusted OR=1.28, 95
KW  - Aged
KW  - Aged, 80 and over
KW  - Anticonvulsants: adverse effects
KW  - Anticonvulsants: therapeutic use
KW  - Case-Control Studies
KW  - Cognition
KW  - Comorbidity
KW  - Correlation of Data
KW  - Dementia: diagnosis
KW  - Dementia: epidemiology
KW  - Female
KW  - Finland: epidemiology
KW  - Geriatric Assessment: methods
KW  - Germany: epidemiology
KW  - Humans
KW  - Insurance Claim Review: statistics & numerical data
KW  - Male
KW  - Registries: statistics & numerical data
KW  - Risk Factors
KW  - Anticonvulsants (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:29566430
DO  - DOI:10.1111/jgs.15358
UR  - https://pub.dzne.de/record/140088
ER  -