% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Taipale:140088,
      author       = {Taipale, Heidi and Gomm, Willy and Broich, Karl and Maier,
                      Wolfgang and Tolppanen, Anna-Maija and Tanskanen, Antti and
                      Tiihonen, Jari and Hartikainen, Sirpa and Haenisch, Britta},
      title        = {{U}se of {A}ntiepileptic {D}rugs and {D}ementia {R}isk-an
                      {A}nalysis of {F}innish {H}ealth {R}egister and {G}erman
                      {H}ealth {I}nsurance {D}ata.},
      journal      = {Journal of the American Geriatrics Society},
      volume       = {66},
      number       = {6},
      issn         = {0002-8614},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {DZNE-2020-06410},
      pages        = {1123-1129},
      year         = {2018},
      abstract     = {To evaluate the association between regular antiepileptic
                      drug (AED) use and incident dementia.Case-control
                      analysis.Finnish public health register and German health
                      insurance data.Individuals with dementia of any type (German
                      data, N=20,325) and Alzheimer's disease (AD; Finnish data,
                      N=70,718) were matched with up to four control persons
                      without dementia.We analyzed the association between regular
                      AED use and dementia. To address potential protopathic bias,
                      a lag time of 2 years between AED use and dementia diagnosis
                      was introduced. Odds ratios (ORs) were calculated by
                      applying conditional logistic regression, adjusted for
                      potential confounding factors such as comorbidities and
                      polypharmacy.Regular AED use was more frequent in
                      individuals with dementia than controls. Regular use of AEDs
                      was associated with a significantly greater risk of incident
                      dementia (adjusted OR=1.28, $95\%$ confidence interval
                      (CI)=1.14-1.44) and AD (adjusted OR=1.15, $95\%$
                      CI=1.09-1.22) than no AED use. We also detected a trend
                      toward greater risk of dementia with higher exposure. When
                      AEDs with and without known cognitive adverse effects (CAEs)
                      were compared, a significantly greater risk of dementia was
                      observed for substances with known CAEs (dementia: OR=1.59,
                      $95\%$ CI=1.36-1.86; AD: OR=1.19, $95\%$ CI=1.11-1.27).AEDs,
                      especially those with known CAEs, may contribute to incident
                      dementia and AD in older persons.},
      keywords     = {Aged / Aged, 80 and over / Anticonvulsants: adverse effects
                      / Anticonvulsants: therapeutic use / Case-Control Studies /
                      Cognition / Comorbidity / Correlation of Data / Dementia:
                      diagnosis / Dementia: epidemiology / Female / Finland:
                      epidemiology / Geriatric Assessment: methods / Germany:
                      epidemiology / Humans / Insurance Claim Review: statistics
                      $\&$ numerical data / Male / Registries: statistics $\&$
                      numerical data / Risk Factors / Anticonvulsants (NLM
                      Chemicals)},
      cin          = {AG Hänisch / U Clinical Researchers - Bonn},
      ddc          = {610},
      cid          = {I:(DE-2719)1013010 / I:(DE-2719)7000001},
      pnm          = {344 - Clinical and Health Care Research (POF3-344) / 345 -
                      Population Studies and Genetics (POF3-345)},
      pid          = {G:(DE-HGF)POF3-344 / G:(DE-HGF)POF3-345},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29566430},
      doi          = {10.1111/jgs.15358},
      url          = {https://pub.dzne.de/record/140088},
}