% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Weber:140109,
      author       = {Weber, Axel and Schwarz, Sigrid C and Tost, Jörg and
                      Trümbach, Dietrich and Winter, Pia and Busato, Florence and
                      Tacik, Pawel and Windhorst, Anita C and Fagny, Maud and
                      Arzberger, Thomas and McLean, Catriona and van Swieten, John
                      C and Schwarz, Johannes and Vogt-Weisenhorn, Daniela and
                      Wurst, Wolfgang and Adhikary, Till and Dickson, Dennis W and
                      Höglinger, Günter U and Müller, Ulrich},
      title        = {{E}pigenome-wide {DNA} methylation profiling in
                      {P}rogressive {S}upranuclear {P}alsy reveals major changes
                      at {DLX}1.},
      journal      = {Nature Communications},
      volume       = {9},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DZNE-2020-06431},
      pages        = {2929},
      year         = {2018},
      abstract     = {Genetic, epigenetic, and environmental factors contribute
                      to the multifactorial disorder progressive supranuclear
                      palsy (PSP). Here, we study epigenetic changes by
                      genome-wide analysis of DNA from postmortem tissue of
                      forebrains of patients and controls and detect significant
                      (P < 0.05) methylation differences at 717 CpG sites in
                      PSP vs. controls. Four-hundred fifty-one of these sites are
                      associated with protein-coding genes. While differential
                      methylation only affects a few sites in most genes, DLX1 is
                      hypermethylated at multiple sites. Expression of an
                      antisense transcript of DLX1, DLX1AS, is reduced in PSP
                      brains. The amount of DLX1 protein is increased in gray
                      matter of PSP forebrains. Pathway analysis suggests that
                      DLX1 influences MAPT-encoded Tau protein. In a cell system,
                      overexpression of DLX1 results in downregulation of MAPT
                      while overexpression of DLX1AS causes upregulation of MAPT.
                      Our observations suggest that altered DLX1 methylation and
                      expression contribute to pathogenesis of PSP by influencing
                      MAPT.},
      keywords     = {Aged / Aged, 80 and over / DNA Methylation: genetics /
                      Epigenesis, Genetic: genetics / Female / Homeodomain
                      Proteins: genetics / Homeodomain Proteins: metabolism /
                      Humans / Male / Supranuclear Palsy, Progressive: genetics /
                      Supranuclear Palsy, Progressive: pathology / Transcription
                      Factors: genetics / Transcription Factors: metabolism / tau
                      Proteins: genetics / tau Proteins: metabolism / Distal-less
                      homeobox proteins (NLM Chemicals) / Homeodomain Proteins
                      (NLM Chemicals) / MAPT protein, human (NLM Chemicals) /
                      Transcription Factors (NLM Chemicals) / tau Proteins (NLM
                      Chemicals)},
      cin          = {AG Höglinger 1 / AG Levin / Ext HZM / AG Wurst},
      ddc          = {500},
      cid          = {I:(DE-2719)1110002 / I:(DE-2719)1111016 /
                      I:(DE-2719)5000050 / I:(DE-2719)1140001},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342) / 344
                      - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-342 / G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30050033},
      pmc          = {pmc:PMC6062504},
      doi          = {10.1038/s41467-018-05325-y},
      url          = {https://pub.dzne.de/record/140109},
}