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| 001 | 140109 | ||
| 005 | 20240504120052.0 | ||
| 024 | 7 | _ | |a 10.1038/s41467-018-05325-y |2 doi |
| 024 | 7 | _ | |a pmid:30050033 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC6062504 |2 pmc |
| 024 | 7 | _ | |a altmetric:45673111 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-06431 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 500 |
| 100 | 1 | _ | |a Weber, Axel |0 P:(DE-HGF)0 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1. |
| 260 | _ | _ | |a [London] |c 2018 |b Nature Publishing Group UK |
| 264 | _ | 1 | |3 online |2 Crossref |b Springer Science and Business Media LLC |c 2018-07-26 |
| 264 | _ | 1 | |3 print |2 Crossref |b Springer Science and Business Media LLC |c 2018-12-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1714743463_33 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Genetic, epigenetic, and environmental factors contribute to the multifactorial disorder progressive supranuclear palsy (PSP). Here, we study epigenetic changes by genome-wide analysis of DNA from postmortem tissue of forebrains of patients and controls and detect significant (P < 0.05) methylation differences at 717 CpG sites in PSP vs. controls. Four-hundred fifty-one of these sites are associated with protein-coding genes. While differential methylation only affects a few sites in most genes, DLX1 is hypermethylated at multiple sites. Expression of an antisense transcript of DLX1, DLX1AS, is reduced in PSP brains. The amount of DLX1 protein is increased in gray matter of PSP forebrains. Pathway analysis suggests that DLX1 influences MAPT-encoded Tau protein. In a cell system, overexpression of DLX1 results in downregulation of MAPT while overexpression of DLX1AS causes upregulation of MAPT. Our observations suggest that altered DLX1 methylation and expression contribute to pathogenesis of PSP by influencing MAPT. |
| 536 | _ | _ | |a 342 - Disease Mechanisms and Model Systems (POF3-342) |0 G:(DE-HGF)POF3-342 |c POF3-342 |f POF III |x 0 |
| 536 | _ | _ | |a 344 - Clinical and Health Care Research (POF3-344) |0 G:(DE-HGF)POF3-344 |c POF3-344 |f POF III |x 1 |
| 542 | _ | _ | |i 2018-07-26 |2 Crossref |u https://creativecommons.org/licenses/by/4.0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Distal-less homeobox proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Homeodomain Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a MAPT protein, human |2 NLM Chemicals |
| 650 | _ | 7 | |a Transcription Factors |2 NLM Chemicals |
| 650 | _ | 7 | |a tau Proteins |2 NLM Chemicals |
| 650 | _ | 2 | |a Aged |2 MeSH |
| 650 | _ | 2 | |a Aged, 80 and over |2 MeSH |
| 650 | _ | 2 | |a DNA Methylation: genetics |2 MeSH |
| 650 | _ | 2 | |a Epigenesis, Genetic: genetics |2 MeSH |
| 650 | _ | 2 | |a Female |2 MeSH |
| 650 | _ | 2 | |a Homeodomain Proteins: genetics |2 MeSH |
| 650 | _ | 2 | |a Homeodomain Proteins: metabolism |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Supranuclear Palsy, Progressive: genetics |2 MeSH |
| 650 | _ | 2 | |a Supranuclear Palsy, Progressive: pathology |2 MeSH |
| 650 | _ | 2 | |a Transcription Factors: genetics |2 MeSH |
| 650 | _ | 2 | |a Transcription Factors: metabolism |2 MeSH |
| 650 | _ | 2 | |a tau Proteins: genetics |2 MeSH |
| 650 | _ | 2 | |a tau Proteins: metabolism |2 MeSH |
| 700 | 1 | _ | |a Schwarz, Sigrid C |0 P:(DE-2719)2812262 |b 1 |u dzne |
| 700 | 1 | _ | |a Tost, Jörg |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Trümbach, Dietrich |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Winter, Pia |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Busato, Florence |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Tacik, Pawel |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Windhorst, Anita C |0 P:(DE-HGF)0 |b 7 |
| 700 | 1 | _ | |a Fagny, Maud |0 P:(DE-HGF)0 |b 8 |
| 700 | 1 | _ | |a Arzberger, Thomas |0 P:(DE-2719)2811333 |b 9 |u dzne |
| 700 | 1 | _ | |a McLean, Catriona |0 P:(DE-HGF)0 |b 10 |
| 700 | 1 | _ | |a van Swieten, John C |0 P:(DE-HGF)0 |b 11 |
| 700 | 1 | _ | |a Schwarz, Johannes |0 P:(DE-HGF)0 |b 12 |
| 700 | 1 | _ | |a Vogt-Weisenhorn, Daniela |0 P:(DE-2719)9000331 |b 13 |u dzne |
| 700 | 1 | _ | |a Wurst, Wolfgang |0 P:(DE-2719)2000028 |b 14 |u dzne |
| 700 | 1 | _ | |a Adhikary, Till |0 P:(DE-HGF)0 |b 15 |
| 700 | 1 | _ | |a Dickson, Dennis W |0 P:(DE-HGF)0 |b 16 |
| 700 | 1 | _ | |a Höglinger, Günter U |0 P:(DE-2719)2811373 |b 17 |u dzne |
| 700 | 1 | _ | |a Müller, Ulrich |0 P:(DE-HGF)0 |b 18 |
| 773 | 1 | 8 | |a 10.1038/s41467-018-05325-y |b : Springer Science and Business Media LLC, 2018-07-26 |n 1 |p 2929 |3 journal-article |2 Crossref |t Nature Communications |v 9 |y 2018 |x 2041-1723 |
| 773 | _ | _ | |a 10.1038/s41467-018-05325-y |g Vol. 9, no. 1, p. 2929 |0 PERI:(DE-600)2553671-0 |n 1 |q 9:1<2929 |p 2929 |t Nature Communications |v 9 |y 2018 |x 2041-1723 |
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| 856 | 7 | _ | |2 Pubmed Central |u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062504 |
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