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@ARTICLE{Lichtenthaler:140123,
      author       = {Lichtenthaler, Stefan and Lemberg, Marius K and Fluhrer,
                      Regina},
      title        = {{P}roteolytic ectodomain shedding of membrane proteins in
                      mammals-hardware, concepts, and recent developments.},
      journal      = {The EMBO journal},
      volume       = {37},
      number       = {15},
      issn         = {0261-4189},
      address      = {Hoboken, NJ [u.a.]},
      publisher    = {Wiley},
      reportid     = {DZNE-2020-06445},
      pages        = {e99456},
      year         = {2018},
      abstract     = {Proteolytic removal of membrane protein ectodomains
                      (ectodomain shedding) is a post-translational modification
                      that controls levels and function of hundreds of membrane
                      proteins. The contributing proteases, referred to as
                      sheddases, act as important molecular switches in processes
                      ranging from signaling to cell adhesion. When deregulated,
                      ectodomain shedding is linked to pathologies such as
                      inflammation and Alzheimer's disease. While proteases of the
                      'a disintegrin and metalloprotease' (ADAM) and 'beta-site
                      APP cleaving enzyme' (BACE) families are widely considered
                      as sheddases, in recent years a much broader range of
                      proteases, including intramembrane and soluble proteases,
                      were shown to catalyze similar cleavage reactions. This
                      review demonstrates that shedding is a fundamental process
                      in cell biology and discusses the current understanding of
                      sheddases and their substrates, molecular mechanisms and
                      cellular localizations, as well as physiological functions
                      of protein ectodomain shedding. Moreover, we provide an
                      operational definition of shedding and highlight recent
                      conceptual advances in the field. While new developments in
                      proteomics facilitate substrate discovery, we expect that
                      shedding is not a rare exception, but rather the rule for
                      many membrane proteins, and that many more interesting
                      shedding functions await discovery.},
      subtyp        = {Review Article},
      keywords     = {ADAM Proteins: metabolism / Amyloid Precursor Protein
                      Secretases: metabolism / Animals / Aspartic Acid
                      Endopeptidases: metabolism / Cell Membrane: metabolism /
                      Humans / Membrane Proteins: metabolism / Protein Domains:
                      physiology / Protein Processing, Post-Translational:
                      physiology / Proteolysis / Signal Transduction / Membrane
                      Proteins (NLM Chemicals) / Amyloid Precursor Protein
                      Secretases (NLM Chemicals) / Aspartic Acid Endopeptidases
                      (NLM Chemicals) / BACE1 protein, human (NLM Chemicals) /
                      ADAM Proteins (NLM Chemicals)},
      cin          = {AG Lichtenthaler / AG Fluhrer},
      ddc          = {570},
      cid          = {I:(DE-2719)1110006 / I:(DE-2719)1110000-2},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29976761},
      pmc          = {pmc:PMC6068445},
      doi          = {10.15252/embj.201899456},
      url          = {https://pub.dzne.de/record/140123},
}