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@ARTICLE{Blanquie:140144,
      author       = {Blanquie, Oriane and Bradke, Frank},
      title        = {{C}ytoskeleton dynamics in axon regeneration.},
      journal      = {Current opinion in neurobiology},
      volume       = {51},
      issn         = {0959-4388},
      address      = {Philadelphia, Pa.},
      publisher    = {Current Biology},
      reportid     = {DZNE-2020-06466},
      pages        = {60-69},
      year         = {2018},
      abstract     = {Recent years have seen cytoskeleton dynamics emerging as a
                      key player in axon regeneration. The cytoskeleton, in
                      particular microtubules and actin, ensures the growth of
                      neuronal processes and maintains the singular, highly
                      polarized shape of neurons. Following injury, adult central
                      axons are tipped by a dystrophic structure, the retraction
                      bulb, which prevents their regeneration. Abnormal
                      cytoskeleton dynamics are responsible for the formation of
                      this growth-incompetent structure but pharmacologically
                      modulating cytoskeleton dynamics of injured axons can
                      transform this structure into a growth-competent growth
                      cone. The cytoskeleton also drives the migration of
                      scar-forming cells after an injury. Targeting its dynamics
                      modifies the composition of the inhibitory environment
                      formed by scar tissue and renders it more permissive for
                      regenerating axons. Hence, cytoskeleton dynamics represent
                      an appealing target to promote axon regeneration. As some of
                      cytoskeleton-targeting drugs are used in the clinics for
                      other purposes, they hold the promise to be used as a basis
                      for a regenerative therapy after a spinal cord injury.},
      subtyp        = {Review Article},
      keywords     = {Animals / Axons: metabolism / Cell Movement / Cicatrix:
                      metabolism / Cicatrix: pathology / Cicatrix: physiopathology
                      / Cytoskeleton: metabolism / Growth Cones: physiology /
                      Humans / Nerve Regeneration: physiology},
      cin          = {AG Bradke},
      ddc          = {610},
      cid          = {I:(DE-2719)1013002},
      pnm          = {341 - Molecular Signaling (POF3-341)},
      pid          = {G:(DE-HGF)POF3-341},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29544200},
      doi          = {10.1016/j.conb.2018.02.024},
      url          = {https://pub.dzne.de/record/140144},
}