Home > Publications Database > Cytoskeleton dynamics in axon regeneration. > print

001     140144
005     20240321220743.0
024 7 _ |a 10.1016/j.conb.2018.02.024
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024 7 _ |a pmid:29544200
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024 7 _ |a 0959-4388
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024 7 _ |a 1873-6882
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024 7 _ |a altmetric:34407701
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037 _ _ |a DZNE-2020-06466
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Blanquie, Oriane
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245 _ _ |a Cytoskeleton dynamics in axon regeneration.
260 _ _ |a Philadelphia, Pa.
|c 2018
|b Current Biology
264 _ 1 |3 print
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|b Elsevier BV
|c 2018-08-01
336 7 _ |a article
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520 _ _ |a Recent years have seen cytoskeleton dynamics emerging as a key player in axon regeneration. The cytoskeleton, in particular microtubules and actin, ensures the growth of neuronal processes and maintains the singular, highly polarized shape of neurons. Following injury, adult central axons are tipped by a dystrophic structure, the retraction bulb, which prevents their regeneration. Abnormal cytoskeleton dynamics are responsible for the formation of this growth-incompetent structure but pharmacologically modulating cytoskeleton dynamics of injured axons can transform this structure into a growth-competent growth cone. The cytoskeleton also drives the migration of scar-forming cells after an injury. Targeting its dynamics modifies the composition of the inhibitory environment formed by scar tissue and renders it more permissive for regenerating axons. Hence, cytoskeleton dynamics represent an appealing target to promote axon regeneration. As some of cytoskeleton-targeting drugs are used in the clinics for other purposes, they hold the promise to be used as a basis for a regenerative therapy after a spinal cord injury.
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542 _ _ |i 2018-08-01
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542 _ _ |i 2018-03-01
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588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Axons: metabolism
|2 MeSH
650 _ 2 |a Cell Movement
|2 MeSH
650 _ 2 |a Cicatrix: metabolism
|2 MeSH
650 _ 2 |a Cicatrix: pathology
|2 MeSH
650 _ 2 |a Cicatrix: physiopathology
|2 MeSH
650 _ 2 |a Cytoskeleton: metabolism
|2 MeSH
650 _ 2 |a Growth Cones: physiology
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Nerve Regeneration: physiology
|2 MeSH
700 1 _ |a Bradke, Frank
|0 P:(DE-2719)2810270
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773 1 8 |a 10.1016/j.conb.2018.02.024
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|t Current Opinion in Neurobiology
|v 51
|y 2018
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773 _ _ |a 10.1016/j.conb.2018.02.024
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856 4 _ |y OpenAccess
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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