TY  - JOUR
AU  - Ciliz, Meltem
AU  - Sartor, Jennifer
AU  - Lindig, Tobias
AU  - Pilotto, Andrea
AU  - Schäffer, Eva
AU  - Weiss, Michael
AU  - Scheltens, Philip
AU  - Becker, Sara
AU  - Hobert, Markus A
AU  - Berg, Daniela
AU  - Liepelt-Scarfone, Inga
AU  - Maetzler, Walter
TI  - Brain-Area Specific White Matter Hyperintensities: Associations to Falls in Parkinson's Disease.
JO  - Journal of Parkinson's Disease
VL  - 8
IS  - 3
SN  - 1877-7171
CY  - Amsterdam
PB  - IOS Press
M1  - DZNE-2020-06469
SP  - 455-462
PY  - 2018
AB  - Falls are common among people with idiopathic Parkinson's disease (IPD) and are suggested to be associated with white matter hyperintensities (WMH) of the brain.To investigate the contribution of brain area-specific WMH to the risk of falls in IPD.In fifty participants with IPD, occurrence and severity of WMH in specific brain areas were determined using Scheltens (without lateralization) and Age-related white matter changes (ARWMC) (with lateralization) scores. Falls were evaluated with the fall item of the Unified PD Rating Scale (UPDRS). Correlations between area-specific WMH and falls were tested with stepwise backward regression and multivariate regression analyses.In this cohort of participants with IPD, left temporal WMH were associated with occurrence of falls. Frontal WMH of both hemispheres showed tendencies towards significance for the association with falls.According to our study, WMH in the left temporal area are significantly associated with falls in IPD. Potential reasons for this association could be deficits in memory, navigation, orientation, auditory processing, and fear conditioning, which are all associated with pathologies of the left temporal lobe.
KW  - Accidental Falls
KW  - Aged
KW  - Brain: diagnostic imaging
KW  - Cross-Sectional Studies
KW  - Female
KW  - Humans
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Middle Aged
KW  - Parkinson Disease: diagnostic imaging
KW  - White Matter: diagnostic imaging
LB  - PUB:(DE-HGF)16
C6  - pmid:30040742
DO  - DOI:10.3233/JPD-181351
UR  - https://pub.dzne.de/record/140147
ER  -