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@ARTICLE{Ciliz:140147,
      author       = {Ciliz, Meltem and Sartor, Jennifer and Lindig, Tobias and
                      Pilotto, Andrea and Schäffer, Eva and Weiss, Michael and
                      Scheltens, Philip and Becker, Sara and Hobert, Markus A and
                      Berg, Daniela and Liepelt-Scarfone, Inga and Maetzler,
                      Walter},
      title        = {{B}rain-{A}rea {S}pecific {W}hite {M}atter
                      {H}yperintensities: {A}ssociations to {F}alls in
                      {P}arkinson's {D}isease.},
      journal      = {Journal of Parkinson's Disease},
      volume       = {8},
      number       = {3},
      issn         = {1877-7171},
      address      = {Amsterdam},
      publisher    = {IOS Press},
      reportid     = {DZNE-2020-06469},
      pages        = {455-462},
      year         = {2018},
      abstract     = {Falls are common among people with idiopathic Parkinson's
                      disease (IPD) and are suggested to be associated with white
                      matter hyperintensities (WMH) of the brain.To investigate
                      the contribution of brain area-specific WMH to the risk of
                      falls in IPD.In fifty participants with IPD, occurrence and
                      severity of WMH in specific brain areas were determined
                      using Scheltens (without lateralization) and Age-related
                      white matter changes (ARWMC) (with lateralization) scores.
                      Falls were evaluated with the fall item of the Unified PD
                      Rating Scale (UPDRS). Correlations between area-specific WMH
                      and falls were tested with stepwise backward regression and
                      multivariate regression analyses.In this cohort of
                      participants with IPD, left temporal WMH were associated
                      with occurrence of falls. Frontal WMH of both hemispheres
                      showed tendencies towards significance for the association
                      with falls.According to our study, WMH in the left temporal
                      area are significantly associated with falls in IPD.
                      Potential reasons for this association could be deficits in
                      memory, navigation, orientation, auditory processing, and
                      fear conditioning, which are all associated with pathologies
                      of the left temporal lobe.},
      keywords     = {Accidental Falls / Aged / Brain: diagnostic imaging /
                      Cross-Sectional Studies / Female / Humans / Magnetic
                      Resonance Imaging / Male / Middle Aged / Parkinson Disease:
                      diagnostic imaging / White Matter: diagnostic imaging},
      cin          = {AG Maetzler / Tübingen common / AG Latz ; AG Latz / Ext
                      UKT / AG Berg ; AG Berg / AG Gasser},
      ddc          = {610},
      cid          = {I:(DE-2719)5000024 / I:(DE-2719)6000018 /
                      I:(DE-2719)1013024 / I:(DE-2719)5000058 / I:(DE-2719)5000055
                      / I:(DE-2719)1210000},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342) / 344
                      - Clinical and Health Care Research (POF3-344) / 345 -
                      Population Studies and Genetics (POF3-345)},
      pid          = {G:(DE-HGF)POF3-342 / G:(DE-HGF)POF3-344 /
                      G:(DE-HGF)POF3-345},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30040742},
      doi          = {10.3233/JPD-181351},
      url          = {https://pub.dzne.de/record/140147},
}