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000140151 0247_ $$2doi$$a10.1038/s41589-018-0108-2
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000140151 037__ $$aDZNE-2020-06473
000140151 041__ $$aEnglish
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000140151 1001_ $$0P:(DE-HGF)0$$aZhang, William H$$b0
000140151 245__ $$aMonitoring hippocampal glycine with the computationally designed optical sensor GlyFS.
000140151 260__ $$aBasingstoke$$bNature Publishing Group$$c2018
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000140151 520__ $$aFluorescent sensors are an essential part of the experimental toolbox of the life sciences, where they are used ubiquitously to visualize intra- and extracellular signaling. In the brain, optical neurotransmitter sensors can shed light on temporal and spatial aspects of signal transmission by directly observing, for instance, neurotransmitter release and spread. Here we report the development and application of the first optical sensor for the amino acid glycine, which is both an inhibitory neurotransmitter and a co-agonist of the N-methyl-D-aspartate receptors (NMDARs) involved in synaptic plasticity. Computational design of a glycine-specific binding protein allowed us to produce the optical glycine FRET sensor (GlyFS), which can be used with single and two-photon excitation fluorescence microscopy. We took advantage of this newly developed sensor to test predictions about the uneven spatial distribution of glycine in extracellular space and to demonstrate that extracellular glycine levels are controlled by plasticity-inducing stimuli.
000140151 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
000140151 542__ $$2Crossref$$i2018-07-30$$uhttp://www.springer.com/tdm
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000140151 650_7 $$2NLM Chemicals$$aFluorescent Dyes
000140151 650_7 $$0TE7660XO1C$$2NLM Chemicals$$aGlycine
000140151 650_2 $$2MeSH$$aAnimals
000140151 650_2 $$2MeSH$$aCells, Cultured
000140151 650_2 $$2MeSH$$aFluorescence Resonance Energy Transfer
000140151 650_2 $$2MeSH$$aFluorescent Dyes: chemical synthesis
000140151 650_2 $$2MeSH$$aFluorescent Dyes: chemistry
000140151 650_2 $$2MeSH$$aGlycine: analysis
000140151 650_2 $$2MeSH$$aHEK293 Cells
000140151 650_2 $$2MeSH$$aHippocampus: chemistry
000140151 650_2 $$2MeSH$$aHumans
000140151 650_2 $$2MeSH$$aMale
000140151 650_2 $$2MeSH$$aOptical Imaging
000140151 650_2 $$2MeSH$$aRats
000140151 650_2 $$2MeSH$$aRats, Wistar
000140151 7001_ $$0P:(DE-HGF)0$$aHerde, Michel K$$b1
000140151 7001_ $$0P:(DE-HGF)0$$aMitchell, Joshua A$$b2
000140151 7001_ $$0P:(DE-HGF)0$$aWhitfield, Jason H$$b3
000140151 7001_ $$0P:(DE-HGF)0$$aWulff, Andreas B$$b4
000140151 7001_ $$0P:(DE-HGF)0$$aVongsouthi, Vanessa$$b5
000140151 7001_ $$0P:(DE-HGF)0$$aSanchez-Romero, Inmaculada$$b6
000140151 7001_ $$0P:(DE-HGF)0$$aGulakova, Polina E$$b7
000140151 7001_ $$0P:(DE-HGF)0$$aMinge, Daniel$$b8
000140151 7001_ $$0P:(DE-HGF)0$$aBreithausen, Björn$$b9
000140151 7001_ $$0P:(DE-HGF)0$$aSchoch, Susanne$$b10
000140151 7001_ $$0P:(DE-HGF)0$$aJanovjak, Harald$$b11
000140151 7001_ $$0P:(DE-HGF)0$$aJackson, Colin J$$b12$$eCorresponding author
000140151 7001_ $$0P:(DE-2719)2811625$$aHenneberger, Christian$$b13$$eLast author
000140151 77318 $$2Crossref$$3journal-article$$a10.1038/s41589-018-0108-2$$b : Springer Science and Business Media LLC, 2018-07-30$$n9$$p861-869$$tNature Chemical Biology$$v14$$x1552-4450$$y2018
000140151 773__ $$0PERI:(DE-600)2190276-8$$a10.1038/s41589-018-0108-2$$gVol. 14, no. 9, p. 861 - 869$$n9$$p861-869$$q14:9<861 - 869$$tNature chemical biology$$v14$$x1552-4450$$y2018
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