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| 001 | 140177 | ||
| 005 | 20240504120054.0 | ||
| 024 | 7 | _ | |a 10.1038/s41467-018-05896-w |2 doi |
| 024 | 7 | _ | |a pmid:30177844 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC6120909 |2 pmc |
| 024 | 7 | _ | |a altmetric:47627073 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-06499 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 500 |
| 100 | 1 | _ | |a Savtchenko, Leonid P |0 P:(DE-HGF)0 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Disentangling astroglial physiology with a realistic cell model in silico. |
| 260 | _ | _ | |a [London] |c 2018 |b Nature Publishing Group UK |
| 264 | _ | 1 | |3 online |2 Crossref |b Springer Science and Business Media LLC |c 2018-09-03 |
| 264 | _ | 1 | |3 print |2 Crossref |b Springer Science and Business Media LLC |c 2018-12-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1714742406_29 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Electrically non-excitable astroglia take up neurotransmitters, buffer extracellular K+ and generate Ca2+ signals that release molecular regulators of neural circuitry. The underlying machinery remains enigmatic, mainly because the sponge-like astrocyte morphology has been difficult to access experimentally or explore theoretically. Here, we systematically incorporate multi-scale, tri-dimensional astroglial architecture into a realistic multi-compartmental cell model, which we constrain by empirical tests and integrate into the NEURON computational biophysical environment. This approach is implemented as a flexible astrocyte-model builder ASTRO. As a proof-of-concept, we explore an in silico astrocyte to evaluate basic cell physiology features inaccessible experimentally. Our simulations suggest that currents generated by glutamate transporters or K+ channels have negligible distant effects on membrane voltage and that individual astrocytes can successfully handle extracellular K+ hotspots. We show how intracellular Ca2+ buffers affect Ca2+ waves and why the classical Ca2+ sparks-and-puffs mechanism is theoretically compatible with common readouts of astroglial Ca2+ imaging. |
| 536 | _ | _ | |a 342 - Disease Mechanisms and Model Systems (POF3-342) |0 G:(DE-HGF)POF3-342 |c POF3-342 |f POF III |x 0 |
| 542 | _ | _ | |i 2018-09-03 |2 Crossref |u https://creativecommons.org/licenses/by/4.0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Amino Acid Transport System X-AG |2 NLM Chemicals |
| 650 | _ | 7 | |a Potassium Channels |2 NLM Chemicals |
| 650 | _ | 7 | |a Calcium |0 SY7Q814VUP |2 NLM Chemicals |
| 650 | _ | 2 | |a Algorithms |2 MeSH |
| 650 | _ | 2 | |a Amino Acid Transport System X-AG: metabolism |2 MeSH |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Astrocytes: metabolism |2 MeSH |
| 650 | _ | 2 | |a Astrocytes: physiology |2 MeSH |
| 650 | _ | 2 | |a Calcium: metabolism |2 MeSH |
| 650 | _ | 2 | |a Computer Simulation |2 MeSH |
| 650 | _ | 2 | |a Hippocampus: cytology |2 MeSH |
| 650 | _ | 2 | |a Membrane Potentials |2 MeSH |
| 650 | _ | 2 | |a Models, Neurological |2 MeSH |
| 650 | _ | 2 | |a Neurons: metabolism |2 MeSH |
| 650 | _ | 2 | |a Patch-Clamp Techniques |2 MeSH |
| 650 | _ | 2 | |a Potassium Channels: metabolism |2 MeSH |
| 650 | _ | 2 | |a Proof of Concept Study |2 MeSH |
| 650 | _ | 2 | |a Rats |2 MeSH |
| 650 | _ | 2 | |a Software |2 MeSH |
| 700 | 1 | _ | |a Bard, Lucie |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Jensen, Thomas P |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Reynolds, James P |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Kraev, Igor |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Medvedev, Nikolay |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Stewart, Michael G |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Henneberger, Christian |0 P:(DE-2719)2811625 |b 7 |u dzne |
| 700 | 1 | _ | |a Rusakov, Dmitri A |0 P:(DE-HGF)0 |b 8 |
| 773 | 1 | 8 | |a 10.1038/s41467-018-05896-w |b : Springer Science and Business Media LLC, 2018-09-03 |n 1 |p 3554 |3 journal-article |2 Crossref |t Nature Communications |v 9 |y 2018 |x 2041-1723 |
| 773 | _ | _ | |a 10.1038/s41467-018-05896-w |g Vol. 9, no. 1, p. 3554 |0 PERI:(DE-600)2553671-0 |n 1 |q 9:1<3554 |p 3554 |t Nature Communications |v 9 |y 2018 |x 2041-1723 |
| 856 | 4 | _ | |y OpenAccess |u https://pub.dzne.de/record/140177/files/DZNE-2020-06499.pdf |
| 856 | 4 | _ | |y OpenAccess |x pdfa |u https://pub.dzne.de/record/140177/files/DZNE-2020-06499.pdf?subformat=pdfa |
| 856 | 7 | _ | |2 Pubmed Central |u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120909 |
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| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 7 |6 P:(DE-2719)2811625 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Erkrankungen des Nervensystems |1 G:(DE-HGF)POF3-340 |0 G:(DE-HGF)POF3-342 |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-300 |4 G:(DE-HGF)POF |v Disease Mechanisms and Model Systems |x 0 |
| 914 | 1 | _ | |y 2018 |
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| 915 | _ | _ | |a Creative Commons Attribution CC BY (No Version) |0 LIC:(DE-HGF)CCBYNV |2 V:(DE-HGF) |b DOAJ |
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