Home > Publications Database > Understanding the role of the perivascular space in cerebral small vessel disease. > print

001     140199
005     20240321220750.0
024 7 _ |a 10.1093/cvr/cvy113
|2 doi
024 7 _ |a pmid:29726891
|2 pmid
024 7 _ |a pmc:PMC6455920
|2 pmc
024 7 _ |a 0008-6363
|2 ISSN
024 7 _ |a 1755-3245
|2 ISSN
024 7 _ |a altmetric:40823730
|2 altmetric
037 _ _ |a DZNE-2020-06521
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Brown, Rosalind
|b 0
245 _ _ |a Understanding the role of the perivascular space in cerebral small vessel disease.
260 _ _ |a Oxford
|c 2018
|b Oxford University Press
264 _ 1 |3 online
|2 Crossref
|b Oxford University Press (OUP)
|c 2018-05-02
264 _ 1 |3 print
|2 Crossref
|b Oxford University Press (OUP)
|c 2018-09-01
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1588854173_31742
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|x Review Article
336 7 _ |a ARTICLE
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336 7 _ |a JOURNAL_ARTICLE
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336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a Small vessel diseases (SVDs) are a group of disorders that result from pathological alteration of the small blood vessels in the brain, including the small arteries, capillaries and veins. Of the 35-36 million people that are estimated to suffer from dementia worldwide, up to 65% have an SVD component. Furthermore, SVD causes 20-25% of strokes, worsens outcome after stroke and is a leading cause of disability, cognitive impairment and poor mobility. Yet the underlying cause(s) of SVD are not fully understood. Magnetic resonance imaging has confirmed enlarged perivascular spaces (PVS) as a hallmark feature of SVD. In healthy tissue, these spaces are proposed to form part of a complex brain fluid drainage system which supports interstitial fluid exchange and may also facilitate clearance of waste products from the brain. The pathophysiological signature of PVS and what this infers about their function and interaction with cerebral microcirculation, plus subsequent downstream effects on lesion development in the brain has not been established. Here we discuss the potential of enlarged PVS to be a unique biomarker for SVD and related brain disorders with a vascular component. We propose that widening of PVS suggests presence of peri-vascular cell debris and other waste products that form part of a vicious cycle involving impaired cerebrovascular reactivity, blood-brain barrier dysfunction, perivascular inflammation and ultimately impaired clearance of waste proteins from the interstitial fluid space, leading to accumulation of toxins, hypoxia, and tissue damage. Here, we outline current knowledge, questions and hypotheses regarding understanding the brain fluid dynamics underpinning dementia and stroke through the common denominator of SVD.
536 _ _ |a 344 - Clinical and Health Care Research (POF3-344)
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542 _ _ |i 2018-05-03
|2 Crossref
|u https://academic.oup.com/journals/pages/about_us/legal/notices
588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Blood-Brain Barrier: physiopathology
|2 MeSH
650 _ 2 |a Cerebral Small Vessel Diseases: diagnostic imaging
|2 MeSH
650 _ 2 |a Cerebral Small Vessel Diseases: pathology
|2 MeSH
650 _ 2 |a Cerebral Small Vessel Diseases: physiopathology
|2 MeSH
650 _ 2 |a Glymphatic System: diagnostic imaging
|2 MeSH
650 _ 2 |a Glymphatic System: pathology
|2 MeSH
650 _ 2 |a Glymphatic System: physiopathology
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Magnetic Resonance Imaging
|2 MeSH
650 _ 2 |a Microvessels: diagnostic imaging
|2 MeSH
650 _ 2 |a Microvessels: pathology
|2 MeSH
650 _ 2 |a Microvessels: physiopathology
|2 MeSH
650 _ 2 |a Prognosis
|2 MeSH
700 1 _ |a Benveniste, Helene
|b 1
700 1 _ |a Black, Sandra E
|b 2
700 1 _ |a Charpak, Serge
|b 3
700 1 _ |a Dichgans, Martin
|0 P:(DE-2719)2000030
|b 4
|u dzne
700 1 _ |a Joutel, Anne
|b 5
700 1 _ |a Nedergaard, Maiken
|b 6
700 1 _ |a Smith, Kenneth J
|b 7
700 1 _ |a Zlokovic, Berislav V
|b 8
700 1 _ |a Wardlaw, Joanna M
|0 P:(DE-HGF)0
|b 9
|e Corresponding author
773 1 8 |a 10.1093/cvr/cvy113
|b : Oxford University Press (OUP), 2018-05-02
|n 11
|p 1462-1473
|3 journal-article
|2 Crossref
|t Cardiovascular Research
|v 114
|y 2018
|x 0008-6363
773 _ _ |a 10.1093/cvr/cvy113
|g Vol. 114, no. 11, p. 1462 - 1473
|0 PERI:(DE-600)1499917-1
|n 11
|q 114:11<1462 - 1473
|p 1462-1473
|t Cardiovascular research
|v 114
|y 2018
|x 0008-6363
856 7 _ |2 Pubmed Central
|u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455920
909 C O |o oai:pub.dzne.de:140199
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 4
|6 P:(DE-2719)2000030
913 1 _ |a DE-HGF
|b Forschungsbereich Gesundheit
|l Erkrankungen des Nervensystems
|1 G:(DE-HGF)POF3-340
|0 G:(DE-HGF)POF3-344
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914 1 _ |y 2018
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999 C 5 |a 10.1007/s10571-015-0277-4
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999 C 5 |a 10.1186/s12916-016-0676-5
|9 -- missing cx lookup --
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999 C 5 |a 10.1111/ane.12440
|9 -- missing cx lookup --
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999 C 5 |a 10.1038/s41593-017-0059-z
|9 -- missing cx lookup --
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|o 10.1038/s41593-017-0059-z
999 C 5 |a 10.1159/000438494
|9 -- missing cx lookup --
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999 C 5 |a 10.1007/s00109-017-1573-x
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999 C 5 |a 10.1002/jmri.10136
|9 -- missing cx lookup --
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999 C 5 |a 10.1002/ana.24242
|9 -- missing cx lookup --
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|o 10.1002/ana.24242
999 C 5 |a 10.1161/STROKEAHA.110.592725
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999 C 5 |a 10.1046/j.0953-816x.2001.01793.x
|9 -- missing cx lookup --
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|o 10.1046/j.0953-816x.2001.01793.x
999 C 5 |a 10.1189/jlb.0303114
|9 -- missing cx lookup --
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|o 10.1189/jlb.0303114
999 C 5 |a 10.1042/CS20160604
|9 -- missing cx lookup --
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|o 10.1042/CS20160604
999 C 5 |a 10.1161/STROKEAHA.111.643080
|9 -- missing cx lookup --
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|o 10.1161/STROKEAHA.111.643080
999 C 5 |a 10.1186/s40478-014-0169-8
|9 -- missing cx lookup --
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|o 10.1186/s40478-014-0169-8
999 C 5 |a 10.1161/CIRCRESAHA.117.311054
|9 -- missing cx lookup --
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|o 10.1161/CIRCRESAHA.117.311054
999 C 5 |a 10.1111/micc.12064
|9 -- missing cx lookup --
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|o 10.1111/micc.12064
999 C 5 |a 10.1172/JCI86950
|9 -- missing cx lookup --
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|o 10.1172/JCI86950
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|9 -- missing cx lookup --
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|o 10.1042/CS20170981
999 C 5 |a 10.1111/j.1471-4159.2010.06958.x
|9 -- missing cx lookup --
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|o 10.1111/j.1471-4159.2010.06958.x
999 C 5 |a 10.1186/s12916-017-0793-9
|9 -- missing cx lookup --
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|o 10.1186/s12916-017-0793-9
999 C 5 |a 10.1007/BF00685305
|9 -- missing cx lookup --
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|o 10.1007/BF00685305
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|9 -- missing cx lookup --
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|o 10.1016/j.cmet.2008.03.010
999 C 5 |a 10.1161/01.RES.43.6.854
|9 -- missing cx lookup --
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|o 10.1161/01.RES.43.6.854
999 C 5 |a 10.1172/JCI39733
|9 -- missing cx lookup --
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|o 10.1172/JCI39733
999 C 5 |a 10.1161/01.STR.0000163080.82766.eb
|9 -- missing cx lookup --
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|o 10.1161/01.STR.0000163080.82766.eb
999 C 5 |a 10.3174/ajnr.A4888
|9 -- missing cx lookup --
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|o 10.3174/ajnr.A4888
999 C 5 |a 10.1002/jmri.22209
|9 -- missing cx lookup --
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|o 10.1002/jmri.22209
999 C 5 |a 10.1093/jnen/62.2.154
|9 -- missing cx lookup --
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|o 10.1093/jnen/62.2.154
999 C 5 |a 10.1016/j.jns.2008.12.036
|9 -- missing cx lookup --
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|o 10.1016/j.jns.2008.12.036
999 C 5 |a 10.1155/2017/9372050
|9 -- missing cx lookup --
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|o 10.1155/2017/9372050
999 C 5 |a 10.1177/0271678X16662891
|9 -- missing cx lookup --
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|o 10.1177/0271678X16662891
999 C 5 |a 10.1002/ana.24573
|9 -- missing cx lookup --
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|o 10.1002/ana.24573
999 C 5 |a 10.1042/CS20160380
|9 -- missing cx lookup --
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|o 10.1042/CS20160380
999 C 5 |a 10.1038/nrn3114
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|o 10.1038/nrn3114
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|o 10.1002/ana.24607
999 C 5 |a 10.1523/JNEUROSCI.1592-13.2013
|9 -- missing cx lookup --
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|o 10.1523/JNEUROSCI.1592-13.2013
999 C 5 |a 10.1002/ana.24271
|9 -- missing cx lookup --
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|o 10.1002/ana.24271
999 C 5 |a 10.1038/nm.2394
|9 -- missing cx lookup --
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|o 10.1038/nm.2394
999 C 5 |a 10.1002/ana.24006
|9 -- missing cx lookup --
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999 C 5 |a 10.1016/j.jalz.2016.09.006
|9 -- missing cx lookup --
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|o 10.1016/j.jalz.2016.09.006
999 C 5 |a 10.1161/01.STR.0000058480.77236.B3
|9 -- missing cx lookup --
|2 Crossref
|o 10.1161/01.STR.0000058480.77236.B3
999 C 5 |a 10.1016/j.neurobiolaging.2007.07.015
|9 -- missing cx lookup --
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|o 10.1016/j.neurobiolaging.2007.07.015
999 C 5 |y 2017
|2 Crossref
|o Raja 2017
999 C 5 |a 10.1212/WNL.50.4.966
|9 -- missing cx lookup --
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|o 10.1212/WNL.50.4.966
999 C 5 |a 10.1016/j.neuron.2014.12.032
|9 -- missing cx lookup --
|2 Crossref
|o 10.1016/j.neuron.2014.12.032
999 C 5 |a 10.1177/0271678X16635657
|9 -- missing cx lookup --
|2 Crossref
|o 10.1177/0271678X16635657
999 C 5 |a 10.1177/0271678X17706449
|9 -- missing cx lookup --
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|o 10.1177/0271678X17706449
999 C 5 |a 10.1136/jnnp.2009.172072
|9 -- missing cx lookup --
|2 Crossref
|o 10.1136/jnnp.2009.172072
999 C 5 |a 10.1212/WNL.0000000000004677
|9 -- missing cx lookup --
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|o 10.1212/WNL.0000000000004677
999 C 5 |a 10.1212/WNL.0000000000003556
|9 -- missing cx lookup --
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|o 10.1212/WNL.0000000000003556
999 C 5 |a 10.1016/j.neulet.2010.09.063
|9 -- missing cx lookup --
|2 Crossref
|o 10.1016/j.neulet.2010.09.063
999 C 5 |a 10.1161/01.STR.27.11.2069
|9 -- missing cx lookup --
|2 Crossref
|o 10.1161/01.STR.27.11.2069
999 C 5 |a 10.1212/01.wnl.0000319691.50117.54
|9 -- missing cx lookup --
|2 Crossref
|o 10.1212/01.wnl.0000319691.50117.54
999 C 5 |a 10.1161/STROKEAHA.115.009589
|9 -- missing cx lookup --
|2 Crossref
|o 10.1161/STROKEAHA.115.009589
999 C 5 |a 10.1161/STROKEAHA.110.611731
|9 -- missing cx lookup --
|2 Crossref
|o 10.1161/STROKEAHA.110.611731
999 C 5 |a 10.1161/STROKEAHA.112.669994
|9 -- missing cx lookup --
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|o 10.1161/STROKEAHA.112.669994
999 C 5 |a 10.1093/brain/awg040
|9 -- missing cx lookup --
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999 C 5 |a 10.1016/S0140-6736(99)00309-8
|9 -- missing cx lookup --
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999 C 5 |a 10.1093/brain/awh023
|9 -- missing cx lookup --
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999 C 5 |y 2017
|2 Crossref
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999 C 5 |a 10.1016/j.devcel.2015.05.008
|9 -- missing cx lookup --
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|o 10.1016/j.devcel.2015.05.008
999 C 5 |a 10.1038/nn.2946
|9 -- missing cx lookup --
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|o 10.1038/nn.2946
999 C 5 |a 10.1038/nature05193
|9 -- missing cx lookup --
|2 Crossref
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999 C 5 |a 10.1038/nature13165
|9 -- missing cx lookup --
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999 C 5 |a 10.1016/j.neuron.2015.06.001
|9 -- missing cx lookup --
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|9 -- missing cx lookup --
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|9 -- missing cx lookup --
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|o 10.1016/j.neuron.2010.09.043
999 C 5 |a 10.1038/nn.4489
|9 -- missing cx lookup --
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|o 10.1038/nn.4489
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|9 -- missing cx lookup --
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|o 10.1038/nm.4482
999 C 5 |a 10.3389/fnene.2010.00005
|9 -- missing cx lookup --
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|o 10.3389/fnene.2010.00005
999 C 5 |a 10.1016/j.cell.2015.10.067
|9 -- missing cx lookup --
|2 Crossref
|o 10.1016/j.cell.2015.10.067
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|9 -- missing cx lookup --
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999 C 5 |a 10.3109/01913123.2011.620220
|9 -- missing cx lookup --
|2 Crossref
|o 10.3109/01913123.2011.620220
999 C 5 |a 10.1002/ana.24512
|9 -- missing cx lookup --
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999 C 5 |a 10.1111/j.1440-1789.2011.01290.x
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999 C 5 |a 10.1111/nan.12188
|9 -- missing cx lookup --
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|o 10.1111/nan.12188
999 C 5 |a 10.1042/CS20160618
|9 -- missing cx lookup --
|2 Crossref
|o 10.1042/CS20160618
999 C 5 |a 10.1042/CS20170004
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|2 Crossref
|o 10.1042/CS20170004
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|9 -- missing cx lookup --
|2 Crossref
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999 C 5 |a 10.1186/s12987-015-0019-5
|9 -- missing cx lookup --
|2 Crossref
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999 C 5 |a 10.1038/nrneurol.2015.119
|9 -- missing cx lookup --
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999 C 5 |a 10.1111/bpa.12159
|9 -- missing cx lookup --
|2 Crossref
|o 10.1111/bpa.12159
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|9 -- missing cx lookup --
|2 Crossref
|o 10.1371/journal.pone.0041636
999 C 5 |a 10.1016/j.nbd.2016.05.015
|9 -- missing cx lookup --
|2 Crossref
|o 10.1016/j.nbd.2016.05.015
999 C 5 |a 10.1172/JCI10498
|9 -- missing cx lookup --
|2 Crossref
|o 10.1172/JCI10498
999 C 5 |a 10.1016/j.neuron.2004.07.017
|9 -- missing cx lookup --
|2 Crossref
|o 10.1016/j.neuron.2004.07.017
999 C 5 |a 10.1016/j.nlm.2014.12.005
|9 -- missing cx lookup --
|2 Crossref
|o 10.1016/j.nlm.2014.12.005
999 C 5 |a 10.1111/j.1750-3639.2007.00094.x
|9 -- missing cx lookup --
|2 Crossref
|o 10.1111/j.1750-3639.2007.00094.x
999 C 5 |a 10.1016/j.bbr.2008.02.005
|9 -- missing cx lookup --
|2 Crossref
|o 10.1016/j.bbr.2008.02.005
999 C 5 |a 10.3389/fnmol.2017.00144
|9 -- missing cx lookup --
|2 Crossref
|o 10.3389/fnmol.2017.00144
999 C 5 |a 10.1126/science.1197623
|9 -- missing cx lookup --
|2 Crossref
|o 10.1126/science.1197623
999 C 5 |a 10.1212/WNL.0b013e3182703fd2
|9 -- missing cx lookup --
|2 Crossref
|o 10.1212/WNL.0b013e3182703fd2
999 C 5 |a 10.3390/brainsci4010150
|9 -- missing cx lookup --
|2 Crossref
|o 10.3390/brainsci4010150
999 C 5 |y 2013
|2 Crossref
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999 C 5 |a 10.1007/s00401-008-0457-0
|9 -- missing cx lookup --
|2 Crossref
|o 10.1007/s00401-008-0457-0
999 C 5 |a 10.1111/j.1750-3639.2008.00133.x
|9 -- missing cx lookup --
|2 Crossref
|o 10.1111/j.1750-3639.2008.00133.x
999 C 5 |a 10.1016/j.bbadis.2015.08.024
|9 -- missing cx lookup --
|2 Crossref
|o 10.1016/j.bbadis.2015.08.024
999 C 5 |a 10.1007/BF03402043
|9 -- missing cx lookup --
|2 Crossref
|o 10.1007/BF03402043
999 C 5 |a 10.21300/18.1.2016.63
|9 -- missing cx lookup --
|2 Crossref
|o 10.21300/18.1.2016.63
999 C 5 |a 10.1016/j.bbadis.2015.10.014
|9 -- missing cx lookup --
|2 Crossref
|o 10.1016/j.bbadis.2015.10.014
999 C 5 |a 10.1161/STROKEAHA.114.006617
|9 -- missing cx lookup --
|2 Crossref
|o 10.1161/STROKEAHA.114.006617
999 C 5 |a 10.1523/JNEUROSCI.2112-16.2017
|9 -- missing cx lookup --
|2 Crossref
|o 10.1523/JNEUROSCI.2112-16.2017
999 C 5 |a 10.1523/JNEUROSCI.3020-14.2014
|9 -- missing cx lookup --
|2 Crossref
|o 10.1523/JNEUROSCI.3020-14.2014
999 C 5 |a 10.1016/j.neurobiolaging.2016.11.002
|9 -- missing cx lookup --
|2 Crossref
|o 10.1016/j.neurobiolaging.2016.11.002
999 C 5 |a 10.1523/JNEUROSCI.3390-16.2017
|9 -- missing cx lookup --
|2 Crossref
|o 10.1523/JNEUROSCI.3390-16.2017
999 C 5 |a 10.1038/s41598-017-00861-x
|9 -- missing cx lookup --
|2 Crossref
|o 10.1038/s41598-017-00861-x
999 C 5 |a 10.1016/j.neuroimage.2017.03.021
|9 -- missing cx lookup --
|2 Crossref
|o 10.1016/j.neuroimage.2017.03.021
999 C 5 |a 10.1126/science.1241224
|9 -- missing cx lookup --
|2 Crossref
|o 10.1126/science.1241224
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|9 -- missing cx lookup --
|2 Crossref
|o 10.1002/mrm.26779
999 C 5 |a 10.1161/STROKEAHA.108.528430
|9 -- missing cx lookup --
|2 Crossref
|o 10.1161/STROKEAHA.108.528430
999 C 5 |a 10.1161/STROKEAHA.109.569855
|9 -- missing cx lookup --
|2 Crossref
|o 10.1161/STROKEAHA.109.569855
999 C 5 |a 10.1016/j.neurobiolaging.2015.09.010
|9 -- missing cx lookup --
|2 Crossref
|o 10.1016/j.neurobiolaging.2015.09.010
999 C 5 |a 10.1038/s41598-018-19781-5
|9 -- missing cx lookup --
|2 Crossref
|o 10.1038/s41598-018-19781-5
999 C 5 |a 10.3233/JAD-132528
|9 -- missing cx lookup --
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|o 10.3233/JAD-132528
999 C 5 |y 2015
|2 Crossref
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999 C 5 |a 10.1126/science.aah4968
|9 -- missing cx lookup --
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999 C 5 |a 10.1126/science.1180962
|9 -- missing cx lookup --
|2 Crossref
|o 10.1126/science.1180962
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|9 -- missing cx lookup --
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|o 10.1007/s11936-017-0555-1
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|9 -- missing cx lookup --
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|9 -- missing cx lookup --
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|o 10.1042/CS20170051
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|9 -- missing cx lookup --
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|o 10.1111/ijs.12490
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|9 -- missing cx lookup --
|2 Crossref
|o 10.1007/s11604-017-0617-z
999 C 5 |a 10.2967/jnumed.116.187211
|9 -- missing cx lookup --
|2 Crossref
|o 10.2967/jnumed.116.187211
999 C 5 |a 10.1042/CS20170146
|9 -- missing cx lookup --
|2 Crossref
|o 10.1042/CS20170146
999 C 5 |a 10.1042/CS20160452
|9 -- missing cx lookup --
|2 Crossref
|o 10.1042/CS20160452
999 C 5 |a 10.1042/CS20160724
|9 -- missing cx lookup --
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|o 10.1042/CS20160724

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21