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000140206 0247_ $$2doi$$a10.1016/j.ophtha.2018.03.026
000140206 0247_ $$2pmid$$apmid:29716786
000140206 0247_ $$2ISSN$$a0161-6420
000140206 0247_ $$2ISSN$$a1549-4713
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000140206 037__ $$aDZNE-2020-06528
000140206 041__ $$aEnglish
000140206 082__ $$a610
000140206 1001_ $$0P:(DE-2719)2811175$$aMauschitz, Matthias M$$b0$$eFirst author$$udzne
000140206 245__ $$aSystemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population.
000140206 260__ $$aAmsterdam [u.a.]$$bElsevier$$c2018
000140206 264_1 $$2Crossref$$3print$$bElsevier BV$$c2018-10-01
000140206 3367_ $$2DRIVER$$aarticle
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000140206 3367_ $$2ORCID$$aJOURNAL_ARTICLE
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000140206 520__ $$aTo investigate systemic and ocular determinants of peripapillary retinal nerve fiber layer thickness (pRNFLT) in the European population.Cross-sectional meta-analysis.A total of 16 084 European adults from 8 cohort studies (mean age range, 56.9±12.3-82.1±4.2 years) of the European Eye Epidemiology (E3) consortium.We examined associations with pRNFLT measured by spectral-domain OCT in each study using multivariable linear regression and pooled results using random effects meta-analysis.Determinants of pRNFLT.Mean pRNFLT ranged from 86.8±21.4 μm in the Rotterdam Study I to 104.7±12.5 μm in the Rotterdam Study III. We found the following factors to be associated with reduced pRNFLT: Older age (β = -0.38 μm/year; 95% confidence interval [CI], -0.57 to -0.18), higher intraocular pressure (IOP) (β = -0.36 μm/mmHg; 95% CI, -0.56 to -0.15), visual impairment (β = -5.50 μm; 95% CI, -9.37 to -1.64), and history of systemic hypertension (β = -0.54 μm; 95% CI, -1.01 to -0.07) and stroke (β = -1.94 μm; 95% CI, -3.17 to -0.72). A suggestive, albeit nonsignificant, association was observed for dementia (β = -3.11 μm; 95% CI, -6.22 to 0.01). Higher pRNFLT was associated with more hyperopic spherical equivalent (β = 1.39 μm/diopter; 95% CI, 1.19-1.59) and smoking (β = 1.53 μm; 95% CI, 1.00-2.06 for current smokers compared with never-smokers).In addition to previously described determinants such as age and refraction, we found that systemic vascular and neurovascular diseases were associated with reduced pRNFLT. These may be of clinical relevance, especially in glaucoma monitoring of patients with newly occurring vascular comorbidities.
000140206 536__ $$0G:(DE-HGF)POF3-345$$a345 - Population Studies and Genetics (POF3-345)$$cPOF3-345$$fPOF III$$x0
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000140206 650_2 $$2MeSH$$aCross-Sectional Studies
000140206 650_2 $$2MeSH$$aDisease Progression
000140206 650_2 $$2MeSH$$aEurope: epidemiology
000140206 650_2 $$2MeSH$$aGlaucoma: diagnosis
000140206 650_2 $$2MeSH$$aGlaucoma: epidemiology
000140206 650_2 $$2MeSH$$aGlaucoma: physiopathology
000140206 650_2 $$2MeSH$$aHumans
000140206 650_2 $$2MeSH$$aIntraocular Pressure: physiology
000140206 650_2 $$2MeSH$$aNerve Fibers: pathology
000140206 650_2 $$2MeSH$$aOptic Disk: pathology
000140206 650_2 $$2MeSH$$aPopulation Surveillance: methods
000140206 650_2 $$2MeSH$$aRetinal Ganglion Cells: pathology
000140206 650_2 $$2MeSH$$aTomography, Optical Coherence: methods
000140206 7001_ $$aBonnemaijer, Pieter W M$$b1
000140206 7001_ $$0P:(DE-2719)2812059$$aDiers, Kersten$$b2$$udzne
000140206 7001_ $$aRauscher, Franziska G$$b3
000140206 7001_ $$aElze, Tobias$$b4
000140206 7001_ $$aEngel, Christoph$$b5
000140206 7001_ $$aLoeffler, Markus$$b6
000140206 7001_ $$aColijn, Johanna Maria$$b7
000140206 7001_ $$aIkram, M Arfan$$b8
000140206 7001_ $$aVingerling, Johannes R$$b9
000140206 7001_ $$aWilliams, Katie M$$b10
000140206 7001_ $$aHammond, Christopher J$$b11
000140206 7001_ $$aCreuzot-Garcher, Catherine$$b12
000140206 7001_ $$aBron, Alain M$$b13
000140206 7001_ $$aSilva, Rufino$$b14
000140206 7001_ $$aNunes, Sandrina$$b15
000140206 7001_ $$aDelcourt, Cécile$$b16
000140206 7001_ $$aCougnard-Grégoire, Audrey$$b17
000140206 7001_ $$aHolz, Frank G$$b18
000140206 7001_ $$aKlaver, Caroline C W$$b19
000140206 7001_ $$0P:(DE-2719)2810403$$aBreteler, Monique M B$$b20$$udzne
000140206 7001_ $$0P:(DE-HGF)0$$aFinger, Robert P$$b21$$eCorresponding author
000140206 7001_ $$aEpidemiology, European Eye$$b22
000140206 7001_ $$aAcar, Niyazi$$b23
000140206 7001_ $$aAnastosopoulos, Eleftherios$$b24
000140206 7001_ $$aAzuara-Blanco, Augusto$$b25
000140206 7001_ $$aBerendschot, Tos$$b26
000140206 7001_ $$aBerendschot, Tos$$b27
000140206 7001_ $$aBergen, Arthur$$b28
000140206 7001_ $$aBertelsen, Geir$$b29
000140206 7001_ $$aBinquet, Christine$$b30
000140206 7001_ $$aBird, Alan$$b31
000140206 7001_ $$aBobak, Martin$$b32
000140206 7001_ $$aLarsen, Morten Bøgelund$$b33
000140206 7001_ $$aBoon, Camiel$$b34
000140206 7001_ $$aBourne, Rupert$$b35
000140206 7001_ $$aBrétillon, Lionel$$b36
000140206 7001_ $$aBroe, Rebecca$$b37
000140206 7001_ $$aBron, Alain$$b38
000140206 7001_ $$aBuitendijk, Gabrielle$$b39
000140206 7001_ $$aCachulo, Maria Luz$$b40
000140206 7001_ $$aCapuano, Vittorio$$b41
000140206 7001_ $$aCarrière, Isabelle$$b42
000140206 7001_ $$aChakravarthy, Usha$$b43
000140206 7001_ $$aChan, Michelle$$b44
000140206 7001_ $$aChang, Petrus$$b45
000140206 7001_ $$aColijn, Johanna$$b46
000140206 7001_ $$aCougnard-Grégoire, Audrey$$b47
000140206 7001_ $$aCree, Angela$$b48
000140206 7001_ $$aCreuzot-Garcher, Catherine$$b49
000140206 7001_ $$aCumberland, Phillippa$$b50
000140206 7001_ $$aCunha-Vaz, José$$b51
000140206 7001_ $$aDaien, Vincent$$b52
000140206 7001_ $$aDe Jong, Eiko$$b53
000140206 7001_ $$aDeak, Gabor$$b54
000140206 7001_ $$aDelcourt, Cécile$$b55
000140206 7001_ $$aDelyfer, Marie-Noëlle$$b56
000140206 7001_ $$aHollander, Anneke den$$b57
000140206 7001_ $$aDietzel, Martha$$b58
000140206 7001_ $$aErke, Maja Gran$$b59
000140206 7001_ $$aFaria, Pedro$$b60
000140206 7001_ $$aFarinha, Claudia$$b61
000140206 7001_ $$aFauser, Sascha$$b62
000140206 7001_ $$aFinger, Robert$$b63
000140206 7001_ $$aFletcher, Astrid$$b64
000140206 7001_ $$aFoster, Paul$$b65
000140206 7001_ $$aFounti, Panayiota$$b66
000140206 7001_ $$aGorgels, Theo$$b67
000140206 7001_ $$aGrauslund, Jakob$$b68
000140206 7001_ $$aGrus, Franz$$b69
000140206 7001_ $$aHammond, Christopher$$b70
000140206 7001_ $$aHense, Hans-Werner$$b71
000140206 7001_ $$aHermann, Manuel$$b72
000140206 7001_ $$aHoehn, René$$b73
000140206 7001_ $$aHogg, Ruth$$b74
000140206 7001_ $$aHolz, Frank$$b75
000140206 7001_ $$aHoyng, Carel$$b76
000140206 7001_ $$aJansonius, Nomdo$$b77
000140206 7001_ $$aJanssen, Sarah$$b78
000140206 7001_ $$aKersten, Eveline$$b79
000140206 7001_ $$aKhawaja, Anthony$$b80
000140206 7001_ $$aKlaver, Caroline$$b81
000140206 7001_ $$aKorobelnik, Jean-François$$b82
000140206 7001_ $$aLamparter, Julia$$b83
000140206 7001_ $$aLe Goff, Mélanie$$b84
000140206 7001_ $$aLechanteur, Yara$$b85
000140206 7001_ $$aLehtimäki, Terho$$b86
000140206 7001_ $$aLeung, Irene$$b87
000140206 7001_ $$aLotery, Andrew$$b88
000140206 7001_ $$aMeester, Magda$$b89
000140206 7001_ $$aMerle, Bénédicte$$b90
000140206 7001_ $$aMeyer Zu Westrup, Verena$$b91
000140206 7001_ $$aMidena, Edoardo$$b92
000140206 7001_ $$aMiotto, Stefania$$b93
000140206 7001_ $$aMirshahi, Alireza$$b94
000140206 7001_ $$aMohan-Saïd, Sadek$$b95
000140206 7001_ $$aMueller, Michael$$b96
000140206 7001_ $$aMuldrew, Alyson$$b97
000140206 7001_ $$aMurta, Joaquim$$b98
000140206 7001_ $$aNickels, Stefan$$b99
000140206 7001_ $$aNunes, Sandrina$$b100
000140206 7001_ $$aOwen, Christopher$$b101
000140206 7001_ $$aPeto, Tunde$$b102
000140206 7001_ $$aPfeiffer, Norbert$$b103
000140206 7001_ $$aPiermarocchi, Stefano$$b104
000140206 7001_ $$aProkofyeva, Elena$$b105
000140206 7001_ $$aRahi, Jugnoo$$b106
000140206 7001_ $$aRaitakari, Olli$$b107
000140206 7001_ $$aRauscher, Franziska$$b108
000140206 7001_ $$aRibeiro, Luisa$$b109
000140206 7001_ $$aRougier, Marie-Bénédicte$$b110
000140206 7001_ $$aRudnicka, Alicja$$b111
000140206 7001_ $$aSahel, José$$b112
000140206 7001_ $$aSalonikiou, Aggeliki$$b113
000140206 7001_ $$aSanchez, Clarisa$$b114
000140206 7001_ $$aSchmitz-Valckenberg, Steffen$$b115
000140206 7001_ $$aSchuster, Alexander$$b116
000140206 7001_ $$aSchweitzer, Cédric$$b117
000140206 7001_ $$aSegato, Tatiana$$b118
000140206 7001_ $$aShehata, Jasmin$$b119
000140206 7001_ $$aSilva, Rufino$$b120
000140206 7001_ $$aSilvestri, Giuliana$$b121
000140206 7001_ $$aSimader, Christian$$b122
000140206 7001_ $$aSouied, Eric$$b123
000140206 7001_ $$aSpeckauskas, Martynas$$b124
000140206 7001_ $$aSpringelkamp, Henriet$$b125
000140206 7001_ $$aTapp, Robyn$$b126
000140206 7001_ $$aTopouzis, Fotis$$b127
000140206 7001_ $$avan Leeuwen, Elisa$$b128
000140206 7001_ $$aVerhoeven, Virginie$$b129
000140206 7001_ $$aVerzijden, Timo$$b130
000140206 7001_ $$aVon Hanno, Therese$$b131
000140206 7001_ $$aWiedemann, Peter$$b132
000140206 7001_ $$aWilliams, Katie$$b133
000140206 7001_ $$aWolfram, Christian$$b134
000140206 7001_ $$aYip, Jennifer$$b135
000140206 7001_ $$aZerbib, Jennyfer$$b136
000140206 77318 $$2Crossref$$3journal-article$$a10.1016/j.ophtha.2018.03.026$$b : Elsevier BV, 2018-10-01$$n10$$p1526-1536$$tOphthalmology$$v125$$x0161-6420$$y2018
000140206 773__ $$0PERI:(DE-600)2015287-5$$a10.1016/j.ophtha.2018.03.026$$gVol. 125, no. 10, p. 1526 - 1536$$n10$$p1526-1536$$q125:10<1526 - 1536$$tOphthalmology$$v125$$x0161-6420$$y2018
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