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@ARTICLE{Overall:140209,
      author       = {Overall, Rupert W and Kempermann, Gerd},
      title        = {{T}he {S}mall {W}orld of {A}dult {H}ippocampal
                      {N}eurogenesis.},
      journal      = {Frontiers in neuroscience},
      volume       = {12},
      issn         = {1662-453X},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {DZNE-2020-06531},
      pages        = {641},
      year         = {2018},
      abstract     = {Making mechanistic sense of genetically complex biological
                      systems such as adult hippocampal neurogenesis poses
                      conceptual and many practical challenges. Transcriptomics
                      studies have helped to move beyond single-gene approaches
                      and have greatly enhanced the accessibility to effects of
                      greater numbers of genes. Typically, however, the number of
                      experimental conditions compared is small and the
                      conclusions remain correspondingly limited. In contrast,
                      studying complex traits in genetic reference populations, in
                      which genetic influences are varied systematically, provides
                      insight into the architecture of relationships between
                      phenotypes and putative molecular mechanisms. We describe
                      that the correlation network among transcripts that builds
                      around the adult neurogenesis phenotype and its
                      endophenotypes is, as expected, a small-world network and
                      scale free. The high degree of connectivity implies that
                      adult neurogenesis is essentially an 'omnigenic' process.
                      From any gene of interest, a link to adult hippocampal
                      neurogenesis can be constructed in just a few steps. We show
                      that, at a minimum correlation of 0.6, the hippocampal
                      transcriptome network associated with adult neurogenesis
                      exhibits only two 'degrees of separation.' This fact has
                      many interesting consequences for our attempts to unravel
                      the (molecular) causality structure underlying adult
                      neurogenesis and other complex biological systems. Our
                      article is not written with the expert on network theory in
                      mind but rather aims to raise interest among
                      neurobiologists, active in neurogenesis and related fields,
                      in network theory and analysis as a set of tools that hold
                      great promise for coping with the study of 'omnigenic'
                      phenotypes and systems.},
      cin          = {AG Kempermann 1},
      ddc          = {610},
      cid          = {I:(DE-2719)1710001},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30294252},
      pmc          = {pmc:PMC6158315},
      doi          = {10.3389/fnins.2018.00641},
      url          = {https://pub.dzne.de/record/140209},
}