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@ARTICLE{Arnoux:140227,
      author       = {Arnoux, Isabelle and Willam, Michael and Griesche, Nadine
                      and Krummeich, Jennifer and Watari, Hirofumi and Offermann,
                      Nina and Weber, Stephanie and Narayan Dey, Partha and Chen,
                      Changwei and Monteiro, Olivia and Büttner, Sven and Meyer,
                      Katharina and Bano, Daniele and Radyushkin, Konstantin and
                      Langston, Rosamund and Lambert, Jeremy J and Wanker, Erich
                      and Methner, Axel and Krauß, Sybille and Schweiger, Susann
                      and Stroh, Albrecht},
      title        = {{M}etformin reverses early cortical network dysfunction and
                      behavior changes in {H}untington's disease.},
      journal      = {eLife},
      volume       = {7},
      issn         = {2050-084X},
      address      = {Cambridge},
      publisher    = {eLife Sciences Publications},
      reportid     = {DZNE-2020-06549},
      pages        = {e38744},
      year         = {2018},
      abstract     = {Catching primal functional changes in early, 'very far from
                      disease onset' (VFDO) stages of Huntington's disease is
                      likely to be the key to a successful therapy. Focusing on
                      VFDO stages, we assessed neuronal microcircuits in
                      premanifest Hdh150 knock-in mice. Employing in vivo
                      two-photon Ca2+ imaging, we revealed an early pattern of
                      circuit dysregulation in the visual cortex - one of the
                      first regions affected in premanifest Huntington's disease -
                      characterized by an increase in activity, an enhanced
                      synchronicity and hyperactive neurons. These findings are
                      accompanied by aberrations in animal behavior. We
                      furthermore show that the antidiabetic drug metformin
                      diminishes aberrant Huntingtin protein load and fully
                      restores both early network activity patterns and behavioral
                      aberrations. This network-centered approach reveals a
                      critical window of vulnerability far before clinical
                      manifestation and establishes metformin as a promising
                      candidate for a chronic therapy starting early in
                      premanifest Huntington's disease pathogenesis long before
                      the onset of clinical symptoms.},
      keywords     = {Animals / Astrocytes: drug effects / Astrocytes: metabolism
                      / Behavior, Animal: drug effects / Caenorhabditis elegans:
                      drug effects / Calcium: metabolism / Cell Respiration: drug
                      effects / Cerebral Cortex: drug effects / Cerebral Cortex:
                      physiopathology / Disease Models, Animal / Huntingtin
                      Protein: metabolism / Huntington Disease: pathology /
                      Huntington Disease: physiopathology / Kinetics / Metformin:
                      pharmacology / Mitochondria: drug effects / Mitochondria:
                      metabolism / Mutant Proteins: metabolism / Nerve Net: drug
                      effects / Nerve Net: physiopathology / Neurons: drug effects
                      / Neurons: metabolism / Photons / Protein Aggregates: drug
                      effects / Protein Biosynthesis / Time-Lapse Imaging /
                      Huntingtin Protein (NLM Chemicals) / Mutant Proteins (NLM
                      Chemicals) / Protein Aggregates (NLM Chemicals) / Metformin
                      (NLM Chemicals) / Calcium (NLM Chemicals)},
      cin          = {AG Krauß / AG Bano / AG Nicotera},
      ddc          = {600},
      cid          = {I:(DE-2719)1011006 / I:(DE-2719)1013003 /
                      I:(DE-2719)5000018},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342) / 341
                      - Molecular Signaling (POF3-341)},
      pid          = {G:(DE-HGF)POF3-342 / G:(DE-HGF)POF3-341},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30179155},
      pmc          = {pmc:PMC6156080},
      doi          = {10.7554/eLife.38744},
      url          = {https://pub.dzne.de/record/140227},
}