000140228 001__ 140228
000140228 005__ 20240504120055.0
000140228 0247_ $$2doi$$a10.7554/eLife.39932
000140228 0247_ $$2pmid$$apmid:30222109
000140228 0247_ $$2pmc$$apmc:PMC6158006
000140228 0247_ $$2altmetric$$aaltmetric:48579747
000140228 037__ $$aDZNE-2020-06550
000140228 041__ $$aEnglish
000140228 082__ $$a600
000140228 1001_ $$0P:(DE-HGF)0$$aGunzelmann, Judith$$b0
000140228 245__ $$aThe microtubule polymerase Stu2 promotes oligomerization of the γ-TuSC for cytoplasmic microtubule nucleation.
000140228 260__ $$aCambridge$$beLife Sciences Publications$$c2018
000140228 264_1 $$2Crossref$$3online$$beLife Sciences Publications, Ltd$$c2018-09-17
000140228 3367_ $$2DRIVER$$aarticle
000140228 3367_ $$2DataCite$$aOutput Types/Journal article
000140228 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1714742829_33
000140228 3367_ $$2BibTeX$$aARTICLE
000140228 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000140228 3367_ $$00$$2EndNote$$aJournal Article
000140228 520__ $$aStu2/XMAP215/ZYG-9/Dis1/Alp14/Msps/ch-TOG family members in association with with γ-tubulin complexes nucleate microtubules, but we know little about the interplay of these nucleation factors. Here, we show that the budding yeast Stu2 in complex with the γ-tubulin receptor Spc72 nucleates microtubules in vitro without the small γ-tubulin complex (γ-TuSC). Upon γ-TuSC addition, Stu2 facilitates Spc72-γ-TuSC interaction by binding to Spc72 and γ-TuSC. Stu2 together with Spc72-γ-TuSC increases microtubule nucleation in a process that is dependent on the TOG domains of Stu2. Importantly, these activities are also important for microtubule nucleation in vivo. Stu2 stabilizes Spc72-γ-TuSC at the minus end of cytoplasmic microtubules (cMTs) and an in vivo assay indicates that cMT nucleation requires the TOG domains of Stu2. Upon γ-tubulin depletion, we observed efficient cMT nucleation away from the spindle pole body (SPB), which was dependent on Stu2. Thus, γ-TuSC restricts cMT assembly to the SPB whereas Stu2 nucleates cMTs together with γ-TuSC and stabilizes γ-TuSC at the cMT minus end.
000140228 536__ $$0G:(DE-HGF)POF3-341$$a341 - Molecular Signaling (POF3-341)$$cPOF3-341$$fPOF III$$x0
000140228 542__ $$2Crossref$$i2018-09-17$$uhttp://creativecommons.org/licenses/by/4.0/
000140228 588__ $$aDataset connected to CrossRef, PubMed,
000140228 650_7 $$2NLM Chemicals$$aMicrotubule-Associated Proteins
000140228 650_7 $$2NLM Chemicals$$aMutant Proteins
000140228 650_7 $$2NLM Chemicals$$aSTU2 protein, S cerevisiae
000140228 650_7 $$2NLM Chemicals$$aSaccharomyces cerevisiae Proteins
000140228 650_7 $$2NLM Chemicals$$aTubulin
000140228 650_2 $$2MeSH$$aMicrotubule-Associated Proteins: chemistry
000140228 650_2 $$2MeSH$$aMicrotubule-Associated Proteins: metabolism
000140228 650_2 $$2MeSH$$aMicrotubules: metabolism
000140228 650_2 $$2MeSH$$aMutant Proteins: metabolism
000140228 650_2 $$2MeSH$$aProtein Binding
000140228 650_2 $$2MeSH$$aProtein Domains
000140228 650_2 $$2MeSH$$aProtein Multimerization
000140228 650_2 $$2MeSH$$aProtein Stability
000140228 650_2 $$2MeSH$$aSaccharomyces cerevisiae Proteins: chemistry
000140228 650_2 $$2MeSH$$aSaccharomyces cerevisiae Proteins: metabolism
000140228 650_2 $$2MeSH$$aTubulin: metabolism
000140228 7001_ $$0P:(DE-HGF)0$$aRüthnick, Diana$$b1
000140228 7001_ $$0P:(DE-2719)2812342$$aLin, Tien-Chen$$b2$$udzne
000140228 7001_ $$0P:(DE-HGF)0$$aZhang, Wanlu$$b3
000140228 7001_ $$0P:(DE-HGF)0$$aNeuner, Annett$$b4
000140228 7001_ $$0P:(DE-HGF)0$$aJäkle, Ursula$$b5
000140228 7001_ $$0P:(DE-HGF)0$$aSchiebel, Elmar$$b6$$eCorresponding author
000140228 77318 $$2Crossref$$3journal-article$$a10.7554/elife.39932$$b : eLife Sciences Publications, Ltd, 2018-09-17$$teLife$$v7$$x2050-084X$$y2018
000140228 773__ $$0PERI:(DE-600)2687154-3$$a10.7554/eLife.39932$$gVol. 7, p. e39932$$pe39932$$q7<e39932$$teLife$$v7$$x2050-084X$$y2018
000140228 8564_ $$uhttps://pub.dzne.de/record/140228/files/DZNE-2020-06550.pdf$$yOpenAccess
000140228 8564_ $$uhttps://pub.dzne.de/record/140228/files/DZNE-2020-06550.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000140228 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158006
000140228 909CO $$ooai:pub.dzne.de:140228$$popenaire$$popen_access$$pVDB$$pdriver$$pdnbdelivery
000140228 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812342$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b2$$kDZNE
000140228 9131_ $$0G:(DE-HGF)POF3-341$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lErkrankungen des Nervensystems$$vMolecular Signaling$$x0
000140228 9141_ $$y2018
000140228 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2022-11-23
000140228 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ
000140228 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2022-11-23
000140228 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2022-11-23
000140228 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record$$d2022-11-23
000140228 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bELIFE : 2021$$d2022-11-23
000140228 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2022-09-23T12:20:44Z
000140228 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2022-09-23T12:20:44Z
000140228 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2022-11-23
000140228 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000140228 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2022-11-23
000140228 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bELIFE : 2021$$d2022-11-23
000140228 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2022-11-23
000140228 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2022-11-23
000140228 9201_ $$0I:(DE-2719)1013002$$kAG Bradke$$lAxon Growth and Regeneration$$x0
000140228 980__ $$ajournal
000140228 980__ $$aVDB
000140228 980__ $$aUNRESTRICTED
000140228 980__ $$aI:(DE-2719)1013002
000140228 9801_ $$aFullTexts
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1083/jcb.98.3.934$$o10.1083/jcb.98.3.934
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1083/jcb.200511010$$o10.1083/jcb.200511010
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1126/science.1221698$$o10.1126/science.1221698
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.7554/eLife.03069$$o10.7554/eLife.03069
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.cell.2007.11.043$$o10.1016/j.cell.2007.11.043
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/ncomms11005$$o10.1038/ncomms11005
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1083/jcb.141.5.1169$$o10.1083/jcb.141.5.1169
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1083/jcb.201007030$$o10.1083/jcb.201007030
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1091/mbc.e06-03-0245$$o10.1091/mbc.e06-03-0245
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1083/jcb.201111123$$o10.1083/jcb.201111123
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.cub.2018.04.008$$o10.1016/j.cub.2018.04.008
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.devcel.2011.09.006$$o10.1016/j.devcel.2011.09.006
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/j.1460-2075.1996.tb00764.x$$o10.1002/j.1460-2075.1996.tb00764.x
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.7554/eLife.10113$$o10.7554/eLife.10113
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/ncb2863$$o10.1038/ncb2863
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1083/jcb.200302030$$o10.1083/jcb.200302030
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/0076-6879(91)96041-o$$o10.1016/0076-6879(91)96041-o
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/yea.1142$$o10.1002/yea.1142
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.devcel.2014.01.001$$o10.1016/j.devcel.2014.01.001
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/j.1460-2075.1996.tb00837.x$$o10.1002/j.1460-2075.1996.tb00837.x
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1093/emboj/16.23.6985$$o10.1093/emboj/16.23.6985
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1093/emboj/17.14.3952$$o10.1093/emboj/17.14.3952
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/(SICI)1097-0061(199907)15:10B<963::AID-YEA399>3.0.CO;2-W$$o10.1002/(SICI)1097-0061(199907)15:10B<963::AID-YEA399>3.0.CO;2-W
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nature09207$$o10.1038/nature09207
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nrm3209$$o10.1038/nrm3209
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.7554/eLife.02208$$o10.7554/eLife.02208
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.tcb.2014.12.002$$o10.1016/j.tcb.2014.12.002
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1083/jcb.201606092$$o10.1083/jcb.201606092
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0960-9822(03)00547-5$$o10.1016/S0960-9822(03)00547-5
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1091/mbc.11.9.2949$$o10.1091/mbc.11.9.2949
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1083/jcb.140.2.377$$o10.1083/jcb.140.2.377
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1126/science.8102497$$o10.1126/science.8102497
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1091/mbc.e06-04-0360$$o10.1091/mbc.e06-04-0360
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1091/mbc.9.8.2201$$o10.1091/mbc.9.8.2201
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nmeth.1401$$o10.1038/nmeth.1401
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/s41598-017-04791-6$$o10.1038/s41598-017-04791-6
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1091/mbc.9.4.775$$o10.1091/mbc.9.4.775
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1093/emboj/18.15.4180$$o10.1093/emboj/18.15.4180
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0076-6879(03)75025-3$$o10.1016/S0076-6879(03)75025-3
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1074/jbc.M114.584300$$o10.1074/jbc.M114.584300
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0962-8924(02)02268-7$$o10.1016/S0962-8924(02)02268-7
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/cr.2009.6$$o10.1038/cr.2009.6
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/ncb3241$$o10.1038/ncb3241
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nrm.2017.75$$o10.1038/nrm.2017.75
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1091/mbc.e03-11-0837$$o10.1091/mbc.e03-11-0837
000140228 999C5 $$2Crossref$$oSikorski 1989$$y1989
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1083/jcb.133.1.111$$o10.1083/jcb.133.1.111
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/s41556-018-0091-6$$o10.1038/s41556-018-0091-6
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1093/emboj/cdg459$$o10.1093/emboj/cdg459
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1083/jcb.200211097$$o10.1083/jcb.200211097
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1083/jcb.201606080$$o10.1083/jcb.201606080
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1083/jcb.139.5.1271$$o10.1083/jcb.139.5.1271
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.1016498108$$o10.1073/pnas.1016498108
000140228 999C5 $$2Crossref$$oWidlund Microtubules: Structure, Regulation and Functions 2012$$tMicrotubules: Structure, Regulation and Functions$$y2012
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/ncb3188$$o10.1038/ncb3188
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/35014051$$o10.1038/35014051
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.cell.2017.05.028$$o10.1016/j.cell.2017.05.028
000140228 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/378578a0$$o10.1038/378578a0