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| 001 | 140242 | ||
| 005 | 20240723121145.0 | ||
| 024 | 7 | _ | |a 10.1038/s41467-018-06398-5 |2 doi |
| 024 | 7 | _ | |a pmid:30279449 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC6168501 |2 pmc |
| 024 | 7 | _ | |a altmetric:49126121 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-06564 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 500 |
| 100 | 1 | _ | |a Sheng, Chao |0 P:(DE-2719)2811310 |b 0 |e First author |u dzne |
| 245 | _ | _ | |a A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation. |
| 260 | _ | _ | |a [London] |c 2018 |b Nature Publishing Group UK |
| 264 | _ | 1 | |3 online |2 Crossref |b Springer Science and Business Media LLC |c 2018-10-02 |
| 264 | _ | 1 | |3 print |2 Crossref |b Springer Science and Business Media LLC |c 2018-12-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1721647416_12033 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Recent reports suggest that induced neurons (iNs), but not induced pluripotent stem cell (iPSC)-derived neurons, largely preserve age-associated traits. Here, we report on the extent of preserved epigenetic and transcriptional aging signatures in directly converted induced neural stem cells (iNSCs). Employing restricted and integration-free expression of SOX2 and c-MYC, we generated a fully functional, bona fide NSC population from adult blood cells that remains highly responsive to regional patterning cues. Upon conversion, low passage iNSCs display a profound loss of age-related DNA methylation signatures, which further erode across extended passaging, thereby approximating the DNA methylation age of isogenic iPSC-derived neural precursors. This epigenetic rejuvenation is accompanied by a lack of age-associated transcriptional signatures and absence of cellular aging hallmarks. We find iNSCs to be competent for modeling pathological protein aggregation and for neurotransplantation, depicting blood-to-NSC conversion as a rapid alternative route for both disease modeling and neuroregeneration. |
| 536 | _ | _ | |a 344 - Clinical and Health Care Research (POF3-344) |0 G:(DE-HGF)POF3-344 |c POF3-344 |f POF III |x 0 |
| 542 | _ | _ | |i 2018-10-02 |2 Crossref |u https://creativecommons.org/licenses/by/4.0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 2 | |a Aging: genetics |2 MeSH |
| 650 | _ | 2 | |a Aging: metabolism |2 MeSH |
| 650 | _ | 2 | |a DNA Methylation |2 MeSH |
| 650 | _ | 2 | |a Epigenesis, Genetic |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Induced Pluripotent Stem Cells |2 MeSH |
| 650 | _ | 2 | |a Machado-Joseph Disease: blood |2 MeSH |
| 650 | _ | 2 | |a Neural Stem Cells |2 MeSH |
| 650 | _ | 2 | |a Peripheral Blood Stem Cells |2 MeSH |
| 700 | 1 | _ | |a Jungverdorben, Johannes |0 P:(DE-2719)2811320 |b 1 |u dzne |
| 700 | 1 | _ | |a Wiethoff, Hendrik |b 2 |
| 700 | 1 | _ | |a Lin, Qiong |b 3 |
| 700 | 1 | _ | |a Flitsch, Lea J |b 4 |
| 700 | 1 | _ | |a Eckert, Daniela |b 5 |
| 700 | 1 | _ | |a Hebisch, Matthias |0 P:(DE-2719)2811349 |b 6 |u dzne |
| 700 | 1 | _ | |a Fischer, Julia |b 7 |
| 700 | 1 | _ | |a Kesavan, Jaideep |b 8 |
| 700 | 1 | _ | |a Weykopf, Beatrice |0 P:(DE-HGF)0 |b 9 |
| 700 | 1 | _ | |a Schneider, Linda |b 10 |
| 700 | 1 | _ | |a Holtkamp, Dominik |b 11 |
| 700 | 1 | _ | |a Beck, Heinz |0 P:(DE-HGF)0 |b 12 |
| 700 | 1 | _ | |a Till, Andreas |b 13 |
| 700 | 1 | _ | |a Wüllner, Ullrich |0 P:(DE-2719)2000056 |b 14 |u dzne |
| 700 | 1 | _ | |a Ziller, Michael J |b 15 |
| 700 | 1 | _ | |a Wagner, Wolfgang |b 16 |
| 700 | 1 | _ | |a Peitz, Michael |0 P:(DE-2719)9000249 |b 17 |e Corresponding author |u dzne |
| 700 | 1 | _ | |a Brüstle, Oliver |0 P:(DE-HGF)0 |b 18 |
| 773 | 1 | 8 | |a 10.1038/s41467-018-06398-5 |b : Springer Science and Business Media LLC, 2018-10-02 |n 1 |p 4047 |3 journal-article |2 Crossref |t Nature Communications |v 9 |y 2018 |x 2041-1723 |
| 773 | _ | _ | |a 10.1038/s41467-018-06398-5 |g Vol. 9, no. 1, p. 4047 |0 PERI:(DE-600)2553671-0 |n 1 |q 9:1<4047 |p 4047 |t Nature Communications |v 9 |y 2018 |x 2041-1723 |
| 856 | 7 | _ | |2 Pubmed Central |u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168501 |
| 856 | 4 | _ | |u https://pub.dzne.de/record/140242/files/DZNE-2020-06564.pdf |y OpenAccess |
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