% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Flasbeck:140254,
      author       = {Flasbeck, Vera and Atucha, Erika and Nakamura, Nozomu H and
                      Yoshida, Motoharu and Sauvage, Magdalena M},
      title        = {{S}patial information is preferentially processed by the
                      distal part of {CA}3: {I}mplication for memory retrieval.},
      journal      = {Behavioural brain research},
      volume       = {354},
      issn         = {0166-4328},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {DZNE-2020-06576},
      pages        = {31-38},
      year         = {2018},
      abstract     = {For the past decades, CA3 was considered as a single
                      functional entity. However, strong differences between the
                      proximal (close to the dentate gyrus) and the distal (close
                      to CA2) parts of CA3 in terms of connectivity patterns, gene
                      expression and electrophysiological properties suggest that
                      it is not the case. We recently showed that proximal CA3
                      (together with distal CA1) preferentially deals with
                      non-spatial information [1]. In contrast to proximal CA3,
                      distal CA3 mainly receives and predominantly projects to
                      spatially tuned areas. Here, we tested if distal CA3
                      preferentially processes spatial information, which would
                      suggest a segregation of the spatial information along the
                      proximodistal axis of CA3. We used a high-resolution imaging
                      technique based on the detection of the expression of the
                      immediate-early gene Arc, commonly used to map activity in
                      the medial temporal lobe. We showed that distal CA3 is
                      strongly recruited in a newly designed delayed
                      nonmatching-to-location task with high memory demands in
                      rats, while proximal CA3 is not. These results indicate a
                      functional segregation of CA3 that mirrors the one reported
                      in CA1, and suggest the existence of a distal CA3- proximal
                      CA1 spatial subnetwork. These findings bring further
                      evidence for the existence of 'specialized' spatial and
                      non-spatial subnetworks segregated along the proximodistal
                      axis of the hippocampus and put forward the 'segregated'
                      view of information processing in the hippocampus as a
                      reasonable alternative to the well-accepted 'integrated'
                      view, according to which spatial and non-spatial information
                      are systematically integrated in the hippocampus to form
                      episodic memory.},
      keywords     = {Animals / Behavior, Animal / CA3 Region, Hippocampal:
                      physiology / Choice Behavior / Cytoskeletal Proteins:
                      metabolism / Male / Maze Learning / Mental Recall:
                      physiology / Nerve Tissue Proteins: metabolism / Rats,
                      Long-Evans / Spatial Memory: physiology / Spatial Processing
                      / Cytoskeletal Proteins (NLM Chemicals) / Nerve Tissue
                      Proteins (NLM Chemicals) / activity regulated
                      cytoskeletal-associated protein (NLM Chemicals)},
      cin          = {AG Yoshida},
      ddc          = {610},
      cid          = {I:(DE-2719)1310011},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30098839},
      doi          = {10.1016/j.bbr.2018.07.023},
      url          = {https://pub.dzne.de/record/140254},
}