TY  - JOUR
AU  - Reboreda, Antonio
AU  - Theissen, Frederik M
AU  - Valero-Aracama, Maria J
AU  - Arboit, Alberto
AU  - Corbu, Mihaela A
AU  - Yoshida, Motoharu
TI  - Do TRPC channels support working memory? Comparing modulations of TRPC channels and working memory through G-protein coupled receptors and neuromodulators.
JO  - Behavioural brain research
VL  - 354
SN  - 0166-4328
CY  - Amsterdam
PB  - Elsevier
M1  - DZNE-2020-06577
SP  - 64-83
PY  - 2018
AB  - Working memory is a crucial ability we use in daily life. However, the cellular mechanisms supporting working memory still remain largely unclear. A key component of working memory is persistent neural firing which is believed to serve short-term (hundreds of milliseconds up to tens of seconds) maintenance of necessary information. In this review, we will focus on the role of transient receptor potential canonical (TRPC) channels as a mechanism underlying persistent firing. Many years of in vitro work have been suggesting a crucial role of TRPC channels in working memory and temporal association tasks. If TRPC channels are indeed a central mechanism for working memory, manipulations which impair or facilitate working memory should have a similar effect on TRPC channel modulation. However, modulations of working memory and TRPC channels were never systematically compared, and it remains unanswered whether TRPC channels indeed contribute to working memory in vivo or not. In this article, we review the effects of G-protein coupled receptors (GPCR) and neuromodulators, including acetylcholine, noradrenalin, serotonin and dopamine, on working memory and TRPC channels. Based on comparisons, we argue that GPCR and downstream signaling pathways that activate TRPC, generally support working memory, while those that suppress TRPC channels impair it. However, depending on the channel types, areas, and systems tested, this is not the case in all studies. Further work to clarify involvement of specific TRPC channels in working memory tasks and how they are affected by neuromodulators is still necessary in the future.
KW  - Acetylcholine: physiology
KW  - Action Potentials
KW  - Animals
KW  - Conditioning, Psychological
KW  - Dopamine: physiology
KW  - Hippocampus: physiology
KW  - Humans
KW  - Memory, Short-Term: physiology
KW  - Neurons: physiology
KW  - Norepinephrine: physiology
KW  - Receptors, G-Protein-Coupled: physiology
KW  - Serotonin: physiology
KW  - TRPC Cation Channels: physiology
KW  - Receptors, G-Protein-Coupled (NLM Chemicals)
KW  - TRPC Cation Channels (NLM Chemicals)
KW  - Serotonin (NLM Chemicals)
KW  - Acetylcholine (NLM Chemicals)
KW  - Dopamine (NLM Chemicals)
KW  - Norepinephrine (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:29501506
DO  - DOI:10.1016/j.bbr.2018.02.042
UR  - https://pub.dzne.de/record/140255
ER  -