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000140340 0247_ $$2doi$$a10.1002/glia.23507
000140340 0247_ $$2pmid$$apmid:30277599
000140340 0247_ $$2ISSN$$a0894-1491
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000140340 041__ $$aEnglish
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000140340 1001_ $$aFülle, Lorenz$$b0
000140340 245__ $$aCCL17 exerts a neuroimmune modulatory function and is expressed in hippocampal neurons.
000140340 260__ $$aBognor Regis [u.a.]$$bWiley-Liss$$c2018
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000140340 520__ $$aChemokines are important signaling molecules in the immune and nervous system. Using a fluorescence reporter mouse model, we demonstrate that the chemokine CCL17, a ligand of the chemokine receptor CCR4, is produced in the murine brain, particularly in a subset of hippocampal CA1 neurons. We found that basal expression of Ccl17 in hippocampal neurons was strongly enhanced by peripheral challenge with lipopolysaccharide (LPS). LPS-mediated induction of Ccl17 in the hippocampus was dependent on local tumor necrosis factor (TNF) signaling, whereas upregulation of Ccl22 required granulocyte-macrophage colony-stimulating factor (GM-CSF). CCL17 deficiency resulted in a diminished microglia density under homeostatic and inflammatory conditions. Further, microglia from naïve Ccl17-deficient mice possessed a reduced cellular volume and a more polarized process tree as assessed by computer-assisted imaging analysis. Regarding the overall branching, cell surface area, and total tree length, the morphology of microglia from naïve Ccl17-deficient mice resembled that of microglia from wild-type mice after LPS stimulation. In line, electrophysiological recordings indicated that CCL17 downmodulates basal synaptic transmission at CA3-CA1 Schaffer collaterals in acute slices from naïve but not LPS-treated animals. Taken together, our data identify CCL17 as a homeostatic and inducible neuromodulatory chemokine affecting the presence and morphology of microglia and synaptic transmission in the hippocampus.
000140340 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
000140340 542__ $$2Crossref$$i2018-09-12$$uhttp://doi.wiley.com/10.1002/tdm_license_1.1
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000140340 650_7 $$2NLM Chemicals$$aCcl17 protein, mouse
000140340 650_7 $$2NLM Chemicals$$aCcl22 protein, mouse
000140340 650_7 $$2NLM Chemicals$$aCcr4 protein, mouse
000140340 650_7 $$2NLM Chemicals$$aChemokine CCL17
000140340 650_7 $$2NLM Chemicals$$aChemokine CCL22
000140340 650_7 $$2NLM Chemicals$$aLipopolysaccharides
000140340 650_7 $$2NLM Chemicals$$aReceptors, CCR4
000140340 650_7 $$2NLM Chemicals$$aTumor Necrosis Factor-alpha
000140340 650_7 $$2NLM Chemicals$$aenhanced green fluorescent protein
000140340 650_7 $$0147336-22-9$$2NLM Chemicals$$aGreen Fluorescent Proteins
000140340 650_7 $$083869-56-1$$2NLM Chemicals$$aGranulocyte-Macrophage Colony-Stimulating Factor
000140340 650_2 $$2MeSH$$aAnimals
000140340 650_2 $$2MeSH$$aChemokine CCL17: genetics
000140340 650_2 $$2MeSH$$aChemokine CCL17: metabolism
000140340 650_2 $$2MeSH$$aChemokine CCL22: metabolism
000140340 650_2 $$2MeSH$$aFemale
000140340 650_2 $$2MeSH$$aGene Expression
000140340 650_2 $$2MeSH$$aGranulocyte-Macrophage Colony-Stimulating Factor: metabolism
000140340 650_2 $$2MeSH$$aGreen Fluorescent Proteins: genetics
000140340 650_2 $$2MeSH$$aGreen Fluorescent Proteins: metabolism
000140340 650_2 $$2MeSH$$aHippocampus: immunology
000140340 650_2 $$2MeSH$$aHippocampus: pathology
000140340 650_2 $$2MeSH$$aHomeostasis: physiology
000140340 650_2 $$2MeSH$$aInflammation: metabolism
000140340 650_2 $$2MeSH$$aInflammation: pathology
000140340 650_2 $$2MeSH$$aLipopolysaccharides
000140340 650_2 $$2MeSH$$aMale
000140340 650_2 $$2MeSH$$aMice, Inbred C57BL
000140340 650_2 $$2MeSH$$aMice, Transgenic
000140340 650_2 $$2MeSH$$aMicroglia: immunology
000140340 650_2 $$2MeSH$$aMicroglia: pathology
000140340 650_2 $$2MeSH$$aMonocytes: immunology
000140340 650_2 $$2MeSH$$aMonocytes: pathology
000140340 650_2 $$2MeSH$$aNeuroimmunomodulation: physiology
000140340 650_2 $$2MeSH$$aNeurons: immunology
000140340 650_2 $$2MeSH$$aNeurons: pathology
000140340 650_2 $$2MeSH$$aReceptors, CCR4: metabolism
000140340 650_2 $$2MeSH$$aSynaptic Transmission: physiology
000140340 650_2 $$2MeSH$$aTumor Necrosis Factor-alpha: metabolism
000140340 7001_ $$0P:(DE-HGF)0$$aOffermann, Nina$$b1
000140340 7001_ $$0P:(DE-HGF)0$$aHansen, Jan Niklas$$b2
000140340 7001_ $$aBreithausen, Björn$$b3
000140340 7001_ $$aErazo, Anna Belen$$b4
000140340 7001_ $$aSchanz, Oliver$$b5
000140340 7001_ $$aRadau, Luca$$b6
000140340 7001_ $$aGondorf, Fabian$$b7
000140340 7001_ $$aKnöpper, Konrad$$b8
000140340 7001_ $$aAlferink, Judith$$b9
000140340 7001_ $$aAbdullah, Zeinab$$b10
000140340 7001_ $$aNeumann, Harald$$b11
000140340 7001_ $$aWeighardt, Heike$$b12
000140340 7001_ $$0P:(DE-2719)2811625$$aHenneberger, Christian$$b13$$udzne
000140340 7001_ $$0P:(DE-2719)2812038$$aHalle, Annett$$b14$$udzne
000140340 7001_ $$0P:(DE-HGF)0$$aFörster, Irmgard$$b15$$eCorresponding author
000140340 77318 $$2Crossref$$3journal-article$$a10.1002/glia.23507$$b : Wiley, 2018-09-12$$n10$$p2246-2261$$tGlia$$v66$$x0894-1491$$y2018
000140340 773__ $$0PERI:(DE-600)1474828-9$$a10.1002/glia.23507$$gVol. 66, no. 10, p. 2246 - 2261$$n10$$p2246-2261$$q66:10<2246 - 2261$$tGlia$$v66$$x0894-1491$$y2018
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