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| 001 | 140340 | ||
| 005 | 20250417142129.0 | ||
| 024 | 7 | _ | |a 10.1002/glia.23507 |2 doi |
| 024 | 7 | _ | |a pmid:30277599 |2 pmid |
| 024 | 7 | _ | |a 0894-1491 |2 ISSN |
| 024 | 7 | _ | |a 1098-1136 |2 ISSN |
| 024 | 7 | _ | |a altmetric:48195495 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-06662 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Fülle, Lorenz |b 0 |
| 245 | _ | _ | |a CCL17 exerts a neuroimmune modulatory function and is expressed in hippocampal neurons. |
| 260 | _ | _ | |a Bognor Regis [u.a.] |c 2018 |b Wiley-Liss |
| 264 | _ | 1 | |3 online |2 Crossref |b Wiley |c 2018-09-12 |
| 264 | _ | 1 | |3 print |2 Crossref |b Wiley |c 2018-10-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1744892447_19520 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Chemokines are important signaling molecules in the immune and nervous system. Using a fluorescence reporter mouse model, we demonstrate that the chemokine CCL17, a ligand of the chemokine receptor CCR4, is produced in the murine brain, particularly in a subset of hippocampal CA1 neurons. We found that basal expression of Ccl17 in hippocampal neurons was strongly enhanced by peripheral challenge with lipopolysaccharide (LPS). LPS-mediated induction of Ccl17 in the hippocampus was dependent on local tumor necrosis factor (TNF) signaling, whereas upregulation of Ccl22 required granulocyte-macrophage colony-stimulating factor (GM-CSF). CCL17 deficiency resulted in a diminished microglia density under homeostatic and inflammatory conditions. Further, microglia from naïve Ccl17-deficient mice possessed a reduced cellular volume and a more polarized process tree as assessed by computer-assisted imaging analysis. Regarding the overall branching, cell surface area, and total tree length, the morphology of microglia from naïve Ccl17-deficient mice resembled that of microglia from wild-type mice after LPS stimulation. In line, electrophysiological recordings indicated that CCL17 downmodulates basal synaptic transmission at CA3-CA1 Schaffer collaterals in acute slices from naïve but not LPS-treated animals. Taken together, our data identify CCL17 as a homeostatic and inducible neuromodulatory chemokine affecting the presence and morphology of microglia and synaptic transmission in the hippocampus. |
| 536 | _ | _ | |a 342 - Disease Mechanisms and Model Systems (POF3-342) |0 G:(DE-HGF)POF3-342 |c POF3-342 |f POF III |x 0 |
| 542 | _ | _ | |i 2018-09-12 |2 Crossref |u http://doi.wiley.com/10.1002/tdm_license_1.1 |
| 542 | _ | _ | |i 2018-09-12 |2 Crossref |u http://onlinelibrary.wiley.com/termsAndConditions#vor |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Ccl17 protein, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a Ccl22 protein, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a Ccr4 protein, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a Chemokine CCL17 |2 NLM Chemicals |
| 650 | _ | 7 | |a Chemokine CCL22 |2 NLM Chemicals |
| 650 | _ | 7 | |a Lipopolysaccharides |2 NLM Chemicals |
| 650 | _ | 7 | |a Receptors, CCR4 |2 NLM Chemicals |
| 650 | _ | 7 | |a Tumor Necrosis Factor-alpha |2 NLM Chemicals |
| 650 | _ | 7 | |a enhanced green fluorescent protein |2 NLM Chemicals |
| 650 | _ | 7 | |a Green Fluorescent Proteins |0 147336-22-9 |2 NLM Chemicals |
| 650 | _ | 7 | |a Granulocyte-Macrophage Colony-Stimulating Factor |0 83869-56-1 |2 NLM Chemicals |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Chemokine CCL17: genetics |2 MeSH |
| 650 | _ | 2 | |a Chemokine CCL17: metabolism |2 MeSH |
| 650 | _ | 2 | |a Chemokine CCL22: metabolism |2 MeSH |
| 650 | _ | 2 | |a Female |2 MeSH |
| 650 | _ | 2 | |a Gene Expression |2 MeSH |
| 650 | _ | 2 | |a Granulocyte-Macrophage Colony-Stimulating Factor: metabolism |2 MeSH |
| 650 | _ | 2 | |a Green Fluorescent Proteins: genetics |2 MeSH |
| 650 | _ | 2 | |a Green Fluorescent Proteins: metabolism |2 MeSH |
| 650 | _ | 2 | |a Hippocampus: immunology |2 MeSH |
| 650 | _ | 2 | |a Hippocampus: pathology |2 MeSH |
| 650 | _ | 2 | |a Homeostasis: physiology |2 MeSH |
| 650 | _ | 2 | |a Inflammation: metabolism |2 MeSH |
| 650 | _ | 2 | |a Inflammation: pathology |2 MeSH |
| 650 | _ | 2 | |a Lipopolysaccharides |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Mice, Inbred C57BL |2 MeSH |
| 650 | _ | 2 | |a Mice, Transgenic |2 MeSH |
| 650 | _ | 2 | |a Microglia: immunology |2 MeSH |
| 650 | _ | 2 | |a Microglia: pathology |2 MeSH |
| 650 | _ | 2 | |a Monocytes: immunology |2 MeSH |
| 650 | _ | 2 | |a Monocytes: pathology |2 MeSH |
| 650 | _ | 2 | |a Neuroimmunomodulation: physiology |2 MeSH |
| 650 | _ | 2 | |a Neurons: immunology |2 MeSH |
| 650 | _ | 2 | |a Neurons: pathology |2 MeSH |
| 650 | _ | 2 | |a Receptors, CCR4: metabolism |2 MeSH |
| 650 | _ | 2 | |a Synaptic Transmission: physiology |2 MeSH |
| 650 | _ | 2 | |a Tumor Necrosis Factor-alpha: metabolism |2 MeSH |
| 700 | 1 | _ | |a Offermann, Nina |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Hansen, Jan Niklas |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Breithausen, Björn |b 3 |
| 700 | 1 | _ | |a Erazo, Anna Belen |b 4 |
| 700 | 1 | _ | |a Schanz, Oliver |b 5 |
| 700 | 1 | _ | |a Radau, Luca |b 6 |
| 700 | 1 | _ | |a Gondorf, Fabian |b 7 |
| 700 | 1 | _ | |a Knöpper, Konrad |b 8 |
| 700 | 1 | _ | |a Alferink, Judith |b 9 |
| 700 | 1 | _ | |a Abdullah, Zeinab |b 10 |
| 700 | 1 | _ | |a Neumann, Harald |b 11 |
| 700 | 1 | _ | |a Weighardt, Heike |b 12 |
| 700 | 1 | _ | |a Henneberger, Christian |0 P:(DE-2719)2811625 |b 13 |u dzne |
| 700 | 1 | _ | |a Halle, Annett |0 P:(DE-2719)2812038 |b 14 |u dzne |
| 700 | 1 | _ | |a Förster, Irmgard |0 P:(DE-HGF)0 |b 15 |e Corresponding author |
| 773 | 1 | 8 | |a 10.1002/glia.23507 |b : Wiley, 2018-09-12 |n 10 |p 2246-2261 |3 journal-article |2 Crossref |t Glia |v 66 |y 2018 |x 0894-1491 |
| 773 | _ | _ | |a 10.1002/glia.23507 |g Vol. 66, no. 10, p. 2246 - 2261 |0 PERI:(DE-600)1474828-9 |n 10 |q 66:10<2246 - 2261 |p 2246-2261 |t Glia |v 66 |y 2018 |x 0894-1491 |
| 856 | 4 | _ | |u https://pub.dzne.de/record/140340/files/DZNE-2020-06662_Restricted.pdf |
| 856 | 4 | _ | |u https://pub.dzne.de/record/140340/files/DZNE-2020-06662_Restricted.pdf?subformat=pdfa |x pdfa |
| 909 | C | O | |p VDB |o oai:pub.dzne.de:140340 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 13 |6 P:(DE-2719)2811625 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 14 |6 P:(DE-2719)2812038 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Erkrankungen des Nervensystems |1 G:(DE-HGF)POF3-340 |0 G:(DE-HGF)POF3-342 |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-300 |4 G:(DE-HGF)POF |v Disease Mechanisms and Model Systems |x 0 |
| 914 | 1 | _ | |y 2018 |
| 915 | _ | _ | |a Nationallizenz |0 StatID:(DE-HGF)0420 |2 StatID |d 2022-11-08 |w ger |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2022-11-08 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2022-11-08 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2022-11-08 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2022-11-08 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2022-11-08 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |d 2022-11-08 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b GLIA : 2021 |d 2022-11-08 |
| 915 | _ | _ | |a IF >= 5 |0 StatID:(DE-HGF)9905 |2 StatID |b GLIA : 2021 |d 2022-11-08 |
| 920 | 1 | _ | |0 I:(DE-2719)7000005 |k U Preclinical Researchers - Bonn |l U Preclinical Researchers - Bonn |x 0 |
| 920 | 1 | _ | |0 I:(DE-2719)1013034 |k AG Halle |l Microglia and Neuroinflammation |x 1 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-2719)7000005 |
| 980 | _ | _ | |a I:(DE-2719)1013034 |
| 980 | _ | _ | |a UNRESTRICTED |
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| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1073/pnas.95.24.14500 |2 Crossref |o 10.1073/pnas.95.24.14500 |
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