%0 Journal Article
%A Hilal, Saima
%A Tan, Chuen Seng
%A Adams, Hieab H H
%A Habes, Mohamad
%A Mok, Vincent
%A Venketasubramanian, Narayanaswamy
%A Hofer, Edith
%A Ikram, M Kamran
%A Abrigo, Jill
%A Vernooij, Meike W
%A Chen, Christopher
%A Hosten, Norbert
%A Volzke, Henry
%A Grabe, Hans J
%A Schmidt, Reinhold
%A Ikram, M Arfan
%T Enlarged perivascular spaces and cognition: A meta-analysis of 5 population-based studies.
%J Neurology
%V 91
%N 9
%@ 0028-3878
%C [S.l.]
%I Ovid
%M DZNE-2020-06689
%P e832-e842
%D 2018
%X To investigate the association of enlarged perivascular spaces (ePVS) with cognition in elderly without dementia.We included 5 studies from the Uniform Neuro-Imaging of Virchow-Robin Space Enlargement (UNIVRSE) consortium, namely the Austrian Stroke Prevention Family Study, Study of Health in Pomerania, Rotterdam Study, Epidemiology of Dementia in Singapore study, and Risk Index for Subclinical Brain Lesions in Hong Kong study. ePVS were counted in 4 regions (mesencephalon, hippocampus, basal ganglia, and centrum semiovale) with harmonized rating across studies. Mini-Mental State Examination (MMSE) and general fluid cognitive ability factor (G-factor) were used to assess cognitive function. For each study, a linear regression model was performed to estimate the effect of ePVS on MMSE and G-factor. Estimates were pooled across studies with the use of inverse variance meta-analysis with fixed- or random-effect models when appropriate.The final sample size consisted of 3,575 persons (age range 63.4-73.2 years, 50.6
%K Aged
%K Brain Edema: complications
%K Brain Edema: diagnostic imaging
%K Cerebral Arteries: pathology
%K Cognition Disorders: diagnostic imaging
%K Cognition Disorders: etiology
%K Community Health Planning
%K Female
%K Humans
%K Magnetic Resonance Imaging
%K Male
%K Middle Aged
%K Neuropsychological Tests
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:30068634
%2 pmc:PMC6133622
%R 10.1212/WNL.0000000000006079
%U https://pub.dzne.de/record/140367