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000140367 0247_ $$2pmc$$apmc:PMC6133622
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000140367 0247_ $$2ISSN$$a1526-632X
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000140367 037__ $$aDZNE-2020-06689
000140367 041__ $$aEnglish
000140367 082__ $$a610
000140367 1001_ $$aHilal, Saima$$b0
000140367 245__ $$aEnlarged perivascular spaces and cognition: A meta-analysis of 5 population-based studies.
000140367 260__ $$a[S.l.]$$bOvid$$c2018
000140367 264_1 $$2Crossref$$3online$$bOvid Technologies (Wolters Kluwer Health)$$c2018-08-01
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000140367 520__ $$aTo investigate the association of enlarged perivascular spaces (ePVS) with cognition in elderly without dementia.We included 5 studies from the Uniform Neuro-Imaging of Virchow-Robin Space Enlargement (UNIVRSE) consortium, namely the Austrian Stroke Prevention Family Study, Study of Health in Pomerania, Rotterdam Study, Epidemiology of Dementia in Singapore study, and Risk Index for Subclinical Brain Lesions in Hong Kong study. ePVS were counted in 4 regions (mesencephalon, hippocampus, basal ganglia, and centrum semiovale) with harmonized rating across studies. Mini-Mental State Examination (MMSE) and general fluid cognitive ability factor (G-factor) were used to assess cognitive function. For each study, a linear regression model was performed to estimate the effect of ePVS on MMSE and G-factor. Estimates were pooled across studies with the use of inverse variance meta-analysis with fixed- or random-effect models when appropriate.The final sample size consisted of 3,575 persons (age range 63.4-73.2 years, 50.6% women). Total ePVS counts were not significantly associated with MMSE score (mean difference per ePVS score increase 0.001, 95% confidence interval [CI] -0.007 to 0.008, p = 0.885) or G-factor (mean difference per ePVS score increase 0.002, 95% CI -0.001 to 0.006, p = 0.148) in age-, sex-, and education-adjusted models. Adjustments for cardiovascular risk factors and MRI markers did not change the results. Repeating the analyses with region-specific ePVS rendered similar results.In this study, we found that ePVS counts were not associated with cognitive dysfunction in the general population. Future studies with longitudinal designs are warranted to examine whether ePVS contribute to cognitive decline.
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000140367 650_2 $$2MeSH$$aAged
000140367 650_2 $$2MeSH$$aBrain Edema: complications
000140367 650_2 $$2MeSH$$aBrain Edema: diagnostic imaging
000140367 650_2 $$2MeSH$$aCerebral Arteries: pathology
000140367 650_2 $$2MeSH$$aCognition Disorders: diagnostic imaging
000140367 650_2 $$2MeSH$$aCognition Disorders: etiology
000140367 650_2 $$2MeSH$$aCommunity Health Planning
000140367 650_2 $$2MeSH$$aFemale
000140367 650_2 $$2MeSH$$aHumans
000140367 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000140367 650_2 $$2MeSH$$aMale
000140367 650_2 $$2MeSH$$aMiddle Aged
000140367 650_2 $$2MeSH$$aNeuropsychological Tests
000140367 7001_ $$aTan, Chuen Seng$$b1
000140367 7001_ $$aAdams, Hieab H H$$b2
000140367 7001_ $$0P:(DE-HGF)0$$aHabes, Mohamad$$b3
000140367 7001_ $$aMok, Vincent$$b4
000140367 7001_ $$aVenketasubramanian, Narayanaswamy$$b5
000140367 7001_ $$aHofer, Edith$$b6
000140367 7001_ $$aIkram, M Kamran$$b7
000140367 7001_ $$aAbrigo, Jill$$b8
000140367 7001_ $$aVernooij, Meike W$$b9
000140367 7001_ $$aChen, Christopher$$b10
000140367 7001_ $$aHosten, Norbert$$b11
000140367 7001_ $$aVolzke, Henry$$b12
000140367 7001_ $$0P:(DE-HGF)0$$aGrabe, Hans J$$b13
000140367 7001_ $$0P:(DE-2719)9000857$$aSchmidt, Reinhold$$b14$$udzne
000140367 7001_ $$0P:(DE-HGF)0$$aIkram, M Arfan$$b15$$eCorresponding author
000140367 77318 $$2Crossref$$3journal-article$$a10.1212/wnl.0000000000006079$$b : Ovid Technologies (Wolters Kluwer Health), 2018-08-01$$n9$$pe832-e842$$tNeurology$$v91$$x0028-3878$$y2018
000140367 773__ $$0PERI:(DE-600)1491874-2$$a10.1212/WNL.0000000000006079$$gVol. 91, no. 9, p. e832 - e842$$n9$$pe832-e842$$q91:9<e832 - e842$$tNeurology$$v91$$x0028-3878$$y2018
000140367 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133622
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