TY  - JOUR
AU  - Hilal, Saima
AU  - Tan, Chuen Seng
AU  - Adams, Hieab H H
AU  - Habes, Mohamad
AU  - Mok, Vincent
AU  - Venketasubramanian, Narayanaswamy
AU  - Hofer, Edith
AU  - Ikram, M Kamran
AU  - Abrigo, Jill
AU  - Vernooij, Meike W
AU  - Chen, Christopher
AU  - Hosten, Norbert
AU  - Volzke, Henry
AU  - Grabe, Hans J
AU  - Schmidt, Reinhold
AU  - Ikram, M Arfan
TI  - Enlarged perivascular spaces and cognition: A meta-analysis of 5 population-based studies.
JO  - Neurology
VL  - 91
IS  - 9
SN  - 0028-3878
CY  - [S.l.]
PB  - Ovid
M1  - DZNE-2020-06689
SP  - e832-e842
PY  - 2018
AB  - To investigate the association of enlarged perivascular spaces (ePVS) with cognition in elderly without dementia.We included 5 studies from the Uniform Neuro-Imaging of Virchow-Robin Space Enlargement (UNIVRSE) consortium, namely the Austrian Stroke Prevention Family Study, Study of Health in Pomerania, Rotterdam Study, Epidemiology of Dementia in Singapore study, and Risk Index for Subclinical Brain Lesions in Hong Kong study. ePVS were counted in 4 regions (mesencephalon, hippocampus, basal ganglia, and centrum semiovale) with harmonized rating across studies. Mini-Mental State Examination (MMSE) and general fluid cognitive ability factor (G-factor) were used to assess cognitive function. For each study, a linear regression model was performed to estimate the effect of ePVS on MMSE and G-factor. Estimates were pooled across studies with the use of inverse variance meta-analysis with fixed- or random-effect models when appropriate.The final sample size consisted of 3,575 persons (age range 63.4-73.2 years, 50.6
KW  - Aged
KW  - Brain Edema: complications
KW  - Brain Edema: diagnostic imaging
KW  - Cerebral Arteries: pathology
KW  - Cognition Disorders: diagnostic imaging
KW  - Cognition Disorders: etiology
KW  - Community Health Planning
KW  - Female
KW  - Humans
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Middle Aged
KW  - Neuropsychological Tests
LB  - PUB:(DE-HGF)16
C6  - pmid:30068634
C2  - pmc:PMC6133622
DO  - DOI:10.1212/WNL.0000000000006079
UR  - https://pub.dzne.de/record/140367
ER  -