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000140384 1001_ $$0P:(DE-2719)9000335$$aWalker, Tara$$b0$$eFirst author$$udzne
000140384 245__ $$aT Lymphocytes Contribute to the Control of Baseline Neural Precursor Cell Proliferation but Not the Exercise-Induced Up-Regulation of Adult Hippocampal Neurogenesis.
000140384 260__ $$aLausanne$$bFrontiers Media$$c2018
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000140384 520__ $$aCross-talk between the peripheral immune system and the central nervous system is important for physiological brain health. T cells are required to maintain normal baseline levels of neural precursor proliferation in the hippocampus of adult mice. We show here that neither T cells, B cells, natural killer cells nor natural killer T cells are required for the increase in hippocampal precursor proliferation that occurs in response to physical exercise. In addition, we demonstrate that a subpopulation of T cells, regulatory T cells, is not involved in maintaining baseline levels of neural precursor proliferation. Even when applied at supraphysiological numbers, populations of both naive and stimulated lymphocytes had no effect on hippocampal precursor proliferation in vitro. In addition, physical activity had no effect on peripheral immune cells in terms of distribution in the bone marrow, lymph nodes or spleen, activation state or chemokine receptor (CXCR4 and CCR9) expression. Together these results suggest that lymphocytes are not involved in translating the peripheral effects of exercise to the neurogenic niche in the hippocampus and further support the idea that the exercise-induced regulation of adult neurogenesis is mechanistically distinct from its baseline control.
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000140384 650_2 $$2MeSH$$aAnimals
000140384 650_2 $$2MeSH$$aB-Lymphocytes: immunology
000140384 650_2 $$2MeSH$$aB-Lymphocytes: metabolism
000140384 650_2 $$2MeSH$$aCell Proliferation
000140384 650_2 $$2MeSH$$aHippocampus: cytology
000140384 650_2 $$2MeSH$$aHippocampus: immunology
000140384 650_2 $$2MeSH$$aKiller Cells, Natural: immunology
000140384 650_2 $$2MeSH$$aKiller Cells, Natural: metabolism
000140384 650_2 $$2MeSH$$aMice, Inbred C57BL
000140384 650_2 $$2MeSH$$aMice, Knockout
000140384 650_2 $$2MeSH$$aMice, Transgenic
000140384 650_2 $$2MeSH$$aNeural Stem Cells: immunology
000140384 650_2 $$2MeSH$$aNeural Stem Cells: metabolism
000140384 650_2 $$2MeSH$$aNeurogenesis: immunology
000140384 650_2 $$2MeSH$$aPhysical Conditioning, Animal: physiology
000140384 650_2 $$2MeSH$$aT-Lymphocytes: immunology
000140384 650_2 $$2MeSH$$aT-Lymphocytes: metabolism
000140384 650_2 $$2MeSH$$aT-Lymphocytes, Regulatory: immunology
000140384 650_2 $$2MeSH$$aT-Lymphocytes, Regulatory: metabolism
000140384 650_2 $$2MeSH$$aUp-Regulation
000140384 7001_ $$aSchallenberg, Sonja$$b1
000140384 7001_ $$0P:(DE-2719)2811674$$aRund, Nicole$$b2$$udzne
000140384 7001_ $$0P:(DE-2719)9000106$$aGrönnert, Lisa$$b3$$udzne
000140384 7001_ $$aRust, Ruslan$$b4
000140384 7001_ $$aKretschmer, Karsten$$b5
000140384 7001_ $$0P:(DE-2719)2000011$$aKempermann, Gerd$$b6$$udzne
000140384 77318 $$2Crossref$$3journal-article$$a10.3389/fimmu.2018.02856$$b : Frontiers Media SA, 2018-12-11$$tFrontiers in Immunology$$v9$$x1664-3224$$y2018
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000140384 8564_ $$uhttps://www.frontiersin.org/articles/10.3389/fimmu.2018.02856/full
000140384 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297802
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