TY  - JOUR
AU  - Walker, Tara
AU  - Schallenberg, Sonja
AU  - Rund, Nicole
AU  - Grönnert, Lisa
AU  - Rust, Ruslan
AU  - Kretschmer, Karsten
AU  - Kempermann, Gerd
TI  - T Lymphocytes Contribute to the Control of Baseline Neural Precursor Cell Proliferation but Not the Exercise-Induced Up-Regulation of Adult Hippocampal Neurogenesis.
JO  - Frontiers in immunology
VL  - 9
SN  - 1664-3224
CY  - Lausanne
PB  - Frontiers Media
M1  - DZNE-2020-06706
SP  - 2856
PY  - 2018
AB  - Cross-talk between the peripheral immune system and the central nervous system is important for physiological brain health. T cells are required to maintain normal baseline levels of neural precursor proliferation in the hippocampus of adult mice. We show here that neither T cells, B cells, natural killer cells nor natural killer T cells are required for the increase in hippocampal precursor proliferation that occurs in response to physical exercise. In addition, we demonstrate that a subpopulation of T cells, regulatory T cells, is not involved in maintaining baseline levels of neural precursor proliferation. Even when applied at supraphysiological numbers, populations of both naive and stimulated lymphocytes had no effect on hippocampal precursor proliferation in vitro. In addition, physical activity had no effect on peripheral immune cells in terms of distribution in the bone marrow, lymph nodes or spleen, activation state or chemokine receptor (CXCR4 and CCR9) expression. Together these results suggest that lymphocytes are not involved in translating the peripheral effects of exercise to the neurogenic niche in the hippocampus and further support the idea that the exercise-induced regulation of adult neurogenesis is mechanistically distinct from its baseline control.
KW  - Animals
KW  - B-Lymphocytes: immunology
KW  - B-Lymphocytes: metabolism
KW  - Cell Proliferation
KW  - Hippocampus: cytology
KW  - Hippocampus: immunology
KW  - Killer Cells, Natural: immunology
KW  - Killer Cells, Natural: metabolism
KW  - Mice, Inbred C57BL
KW  - Mice, Knockout
KW  - Mice, Transgenic
KW  - Neural Stem Cells: immunology
KW  - Neural Stem Cells: metabolism
KW  - Neurogenesis: immunology
KW  - Physical Conditioning, Animal: physiology
KW  - T-Lymphocytes: immunology
KW  - T-Lymphocytes: metabolism
KW  - T-Lymphocytes, Regulatory: immunology
KW  - T-Lymphocytes, Regulatory: metabolism
KW  - Up-Regulation
LB  - PUB:(DE-HGF)16
C6  - pmid:30619254
C2  - pmc:PMC6297802
DO  - DOI:10.3389/fimmu.2018.02856
UR  - https://pub.dzne.de/record/140384
ER  -