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@ARTICLE{Walker:140384,
      author       = {Walker, Tara and Schallenberg, Sonja and Rund, Nicole and
                      Grönnert, Lisa and Rust, Ruslan and Kretschmer, Karsten and
                      Kempermann, Gerd},
      title        = {{T} {L}ymphocytes {C}ontribute to the {C}ontrol of
                      {B}aseline {N}eural {P}recursor {C}ell {P}roliferation but
                      {N}ot the {E}xercise-{I}nduced {U}p-{R}egulation of {A}dult
                      {H}ippocampal {N}eurogenesis.},
      journal      = {Frontiers in immunology},
      volume       = {9},
      issn         = {1664-3224},
      address      = {Lausanne},
      publisher    = {Frontiers Media},
      reportid     = {DZNE-2020-06706},
      pages        = {2856},
      year         = {2018},
      abstract     = {Cross-talk between the peripheral immune system and the
                      central nervous system is important for physiological brain
                      health. T cells are required to maintain normal baseline
                      levels of neural precursor proliferation in the hippocampus
                      of adult mice. We show here that neither T cells, B cells,
                      natural killer cells nor natural killer T cells are required
                      for the increase in hippocampal precursor proliferation that
                      occurs in response to physical exercise. In addition, we
                      demonstrate that a subpopulation of T cells, regulatory T
                      cells, is not involved in maintaining baseline levels of
                      neural precursor proliferation. Even when applied at
                      supraphysiological numbers, populations of both naive and
                      stimulated lymphocytes had no effect on hippocampal
                      precursor proliferation in vitro. In addition, physical
                      activity had no effect on peripheral immune cells in terms
                      of distribution in the bone marrow, lymph nodes or spleen,
                      activation state or chemokine receptor (CXCR4 and CCR9)
                      expression. Together these results suggest that lymphocytes
                      are not involved in translating the peripheral effects of
                      exercise to the neurogenic niche in the hippocampus and
                      further support the idea that the exercise-induced
                      regulation of adult neurogenesis is mechanistically distinct
                      from its baseline control.},
      keywords     = {Animals / B-Lymphocytes: immunology / B-Lymphocytes:
                      metabolism / Cell Proliferation / Hippocampus: cytology /
                      Hippocampus: immunology / Killer Cells, Natural: immunology
                      / Killer Cells, Natural: metabolism / Mice, Inbred C57BL /
                      Mice, Knockout / Mice, Transgenic / Neural Stem Cells:
                      immunology / Neural Stem Cells: metabolism / Neurogenesis:
                      immunology / Physical Conditioning, Animal: physiology /
                      T-Lymphocytes: immunology / T-Lymphocytes: metabolism /
                      T-Lymphocytes, Regulatory: immunology / T-Lymphocytes,
                      Regulatory: metabolism / Up-Regulation},
      cin          = {AG Kempermann 1},
      ddc          = {610},
      cid          = {I:(DE-2719)1710001},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30619254},
      pmc          = {pmc:PMC6297802},
      doi          = {10.3389/fimmu.2018.02856},
      url          = {https://pub.dzne.de/record/140384},
}