guest ::
| Home > Publications Database > miR-191 modulates B-cell development and targets transcription factors E2A, Foxp1, and Egr1. > print |
| Home > Publications Database > miR-191 modulates B-cell development and targets transcription factors E2A, Foxp1, and Egr1. > print |
| 001 | 140412 | ||
| 005 | 20250417132535.0 | ||
| 024 | 7 | _ | |a 10.1002/eji.201847660 |2 doi |
| 024 | 7 | _ | |a pmid:30281154 |2 pmid |
| 024 | 7 | _ | |a 0014-2980 |2 ISSN |
| 024 | 7 | _ | |a 1521-4141 |2 ISSN |
| 024 | 7 | _ | |a altmetric:49210750 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-06734 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Blume, Jonas |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a miR-191 modulates B-cell development and targets transcription factors E2A, Foxp1, and Egr1. |
| 260 | _ | _ | |a Weinheim |c 2019 |b Wiley-VCH |
| 264 | _ | 1 | |3 online |2 Crossref |b Wiley |c 2018-10-22 |
| 264 | _ | 1 | |3 print |2 Crossref |b Wiley |c 2019-01-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1744889091_11896 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a The interdependence of posttranscriptional gene regulation via miRNA and transcriptional regulatory networks in lymphocyte development is poorly understood. Here, we identified miR-191 as direct upstream modulator of a transcriptional module comprising the transcription factors Foxp1, E2A, and Egr1. Deletion as well as ectopic expression of miR-191 resulted in developmental arrest in B lineage cells, indicating that fine tuning of the combined expression levels of Foxp1, E2A, and Egr1, which in turn control somatic recombination and cytokine-driven expansion, constitutes a prerequisite for efficient B-cell development. In conclusion, we propose that miR-191 acts as a rheostat in B-cell development by fine tuning a key transcriptional program. |
| 536 | _ | _ | |a 342 - Disease Mechanisms and Model Systems (POF3-342) |0 G:(DE-HGF)POF3-342 |c POF3-342 |f POF III |x 0 |
| 542 | _ | _ | |i 2018-10-22 |2 Crossref |u http://doi.wiley.com/10.1002/tdm_license_1.1 |
| 542 | _ | _ | |i 2018-10-22 |2 Crossref |u http://onlinelibrary.wiley.com/termsAndConditions#vor |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Basic Helix-Loop-Helix Transcription Factors |2 NLM Chemicals |
| 650 | _ | 7 | |a Early Growth Response Protein 1 |2 NLM Chemicals |
| 650 | _ | 7 | |a Egr1 protein, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a Forkhead Transcription Factors |2 NLM Chemicals |
| 650 | _ | 7 | |a Foxp1 protein, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a MIRN191 microRNA, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a MicroRNAs |2 NLM Chemicals |
| 650 | _ | 7 | |a RNA, Small Interfering |2 NLM Chemicals |
| 650 | _ | 7 | |a Repressor Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Tcf3 protein, mouse |2 NLM Chemicals |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a B-Lymphocytes: physiology |2 MeSH |
| 650 | _ | 2 | |a Basic Helix-Loop-Helix Transcription Factors: genetics |2 MeSH |
| 650 | _ | 2 | |a Basic Helix-Loop-Helix Transcription Factors: metabolism |2 MeSH |
| 650 | _ | 2 | |a Cell Differentiation |2 MeSH |
| 650 | _ | 2 | |a Cells, Cultured |2 MeSH |
| 650 | _ | 2 | |a Early Growth Response Protein 1: genetics |2 MeSH |
| 650 | _ | 2 | |a Early Growth Response Protein 1: metabolism |2 MeSH |
| 650 | _ | 2 | |a Forkhead Transcription Factors: genetics |2 MeSH |
| 650 | _ | 2 | |a Forkhead Transcription Factors: metabolism |2 MeSH |
| 650 | _ | 2 | |a Gene Regulatory Networks |2 MeSH |
| 650 | _ | 2 | |a Mice |2 MeSH |
| 650 | _ | 2 | |a Mice, Inbred C57BL |2 MeSH |
| 650 | _ | 2 | |a Mice, Knockout |2 MeSH |
| 650 | _ | 2 | |a MicroRNAs: genetics |2 MeSH |
| 650 | _ | 2 | |a RNA, Small Interfering: genetics |2 MeSH |
| 650 | _ | 2 | |a Recombination, Genetic |2 MeSH |
| 650 | _ | 2 | |a Repressor Proteins: genetics |2 MeSH |
| 650 | _ | 2 | |a Repressor Proteins: metabolism |2 MeSH |
| 650 | _ | 2 | |a Transcription, Genetic |2 MeSH |
| 650 | _ | 2 | |a Transgenes: genetics |2 MeSH |
| 700 | 1 | _ | |a Ziętara, Natalia |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Witzlau, Katrin |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Liu, Yanshan |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Sanchez, Oskar Ortiz |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Puchałka, Jacek |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Winter, Samantha J |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Kunze-Schumacher, Heike |0 P:(DE-HGF)0 |b 7 |
| 700 | 1 | _ | |a Saran, Namita |0 P:(DE-HGF)0 |b 8 |
| 700 | 1 | _ | |a Düber, Sandra |0 P:(DE-HGF)0 |b 9 |
| 700 | 1 | _ | |a Roy, Bishnudeo |0 P:(DE-HGF)0 |b 10 |
| 700 | 1 | _ | |a Weiss, Siegfried |0 P:(DE-HGF)0 |b 11 |
| 700 | 1 | _ | |a Klein, Christoph |0 P:(DE-HGF)0 |b 12 |
| 700 | 1 | _ | |a Wurst, Wolfgang |0 P:(DE-2719)2000028 |b 13 |u dzne |
| 700 | 1 | _ | |a Łyszkiewicz, Marcin |0 P:(DE-HGF)0 |b 14 |e Corresponding author |
| 700 | 1 | _ | |a Krueger, Andreas |0 P:(DE-HGF)0 |b 15 |
| 773 | 1 | 8 | |a 10.1002/eji.201847660 |b : Wiley, 2018-10-22 |n 1 |p 121-132 |3 journal-article |2 Crossref |t European Journal of Immunology |v 49 |y 2018 |x 0014-2980 |
| 773 | _ | _ | |a 10.1002/eji.201847660 |g Vol. 49, no. 1, p. 121 - 132 |0 PERI:(DE-600)1491907-2 |n 1 |q 49:1<121 - 132 |p 121-132 |t European journal of immunology |v 49 |y 2019 |x 0014-2980 |
| 856 | 4 | _ | |u https://pub.dzne.de/record/140412/files/DZNE-2020-06734_Restricted.pdf |
| 856 | 4 | _ | |u https://pub.dzne.de/record/140412/files/DZNE-2020-06734_Restricted.pdf?subformat=pdfa |x pdfa |
| 909 | C | O | |p VDB |o oai:pub.dzne.de:140412 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 13 |6 P:(DE-2719)2000028 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Erkrankungen des Nervensystems |1 G:(DE-HGF)POF3-340 |0 G:(DE-HGF)POF3-342 |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-300 |4 G:(DE-HGF)POF |v Disease Mechanisms and Model Systems |x 0 |
| 914 | 1 | _ | |y 2019 |
| 915 | _ | _ | |a Nationallizenz |0 StatID:(DE-HGF)0420 |2 StatID |d 2023-03-30 |w ger |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b EUR J IMMUNOL : 2021 |d 2023-03-30 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2023-03-30 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2023-03-30 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2023-03-30 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2023-03-30 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2023-03-30 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |d 2023-03-30 |
| 915 | _ | _ | |a IF >= 5 |0 StatID:(DE-HGF)9905 |2 StatID |b EUR J IMMUNOL : 2021 |d 2023-03-30 |
| 920 | 1 | _ | |0 I:(DE-2719)1140001 |k AG Wurst |l Genome Engineering |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-2719)1140001 |
| 980 | _ | _ | |a UNRESTRICTED |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1146/annurev.immunol.22.012703.104807 |2 Crossref |o 10.1146/annurev.immunol.22.012703.104807 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nri1633 |2 Crossref |o 10.1038/nri1633 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1101/gad.291504 |2 Crossref |o 10.1101/gad.291504 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/ni1358 |2 Crossref |o 10.1038/ni1358 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.cell.2008.02.020 |2 Crossref |o 10.1016/j.cell.2008.02.020 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.biocel.2010.03.004 |2 Crossref |o 10.1016/j.biocel.2010.03.004 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nature03552 |2 Crossref |o 10.1038/nature03552 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.cell.2008.02.019 |2 Crossref |o 10.1016/j.cell.2008.02.019 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/ni1575 |2 Crossref |o 10.1038/ni1575 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1073/pnas.0602266103 |2 Crossref |o 10.1073/pnas.0602266103 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.molcel.2012.10.002 |2 Crossref |o 10.1016/j.molcel.2012.10.002 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/S1074-7613(00)80078-3 |2 Crossref |o 10.1016/S1074-7613(00)80078-3 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1084/jem.194.5.645 |2 Crossref |o 10.1084/jem.194.5.645 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/ni.1891 |2 Crossref |o 10.1038/ni.1891 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.immuni.2018.04.024 |2 Crossref |o 10.1016/j.immuni.2018.04.024 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.4049/jimmunol.181.7.4590 |2 Crossref |o 10.4049/jimmunol.181.7.4590 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1074/jbc.270.17.9971 |2 Crossref |o 10.1074/jbc.270.17.9971 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1084/jem.183.4.1747 |2 Crossref |o 10.1084/jem.183.4.1747 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.immuni.2010.06.013 |2 Crossref |o 10.1016/j.immuni.2010.06.013 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1371/journal.pgen.1006623 |2 Crossref |o 10.1371/journal.pgen.1006623 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/376263a0 |2 Crossref |o 10.1038/376263a0 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1073/pnas.232299999 |2 Crossref |o 10.1073/pnas.232299999 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.immuni.2010.05.009 |2 Crossref |o 10.1016/j.immuni.2010.05.009 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/S1074-7613(03)00181-X |2 Crossref |o 10.1016/S1074-7613(03)00181-X |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/0092-8674(94)90077-9 |2 Crossref |o 10.1016/0092-8674(94)90077-9 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1128/MCB.15.8.4518 |2 Crossref |o 10.1128/MCB.15.8.4518 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1084/jem.20090756 |2 Crossref |o 10.1084/jem.20090756 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/ni.2887 |2 Crossref |o 10.1038/ni.2887 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1101/pdb.prot090704 |2 Crossref |o 10.1101/pdb.prot090704 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1126/science.1231143 |2 Crossref |o 10.1126/science.1231143 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nprot.2013.142 |2 Crossref |o 10.1038/nprot.2013.142 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1182/blood-2014-07-592667 |2 Crossref |o 10.1182/blood-2014-07-592667 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1126/science.1091903 |2 Crossref |o 10.1126/science.1091903 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1073/pnas.96.3.996 |2 Crossref |o 10.1073/pnas.96.3.996 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/ni923 |2 Crossref |o 10.1038/ni923 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.cell.2006.05.042 |2 Crossref |o 10.1016/j.cell.2006.05.042 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.cell.2011.08.023 |2 Crossref |o 10.1016/j.cell.2011.08.023 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1182/blood-2009-04-218156 |2 Crossref |o 10.1182/blood-2009-04-218156 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1002/eji.201646632 |2 Crossref |o 10.1002/eji.201646632 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1002/cyto.a.22451 |2 Crossref |o 10.1002/cyto.a.22451 |
| 999 | C | 5 | |y 1995 |2 Crossref |o Connor 1995 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1002/j.1460-2075.1986.tb04672.x |2 Crossref |o 10.1002/j.1460-2075.1986.tb04672.x |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1101/gad.5.8.1367 |2 Crossref |o 10.1101/gad.5.8.1367 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1128/MCB.18.11.6253 |2 Crossref |o 10.1128/MCB.18.11.6253 |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|